Gene Symbol: PDC2
Species: Saccharomyces cerevisiae S288c
Hohmann S. Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae. Mol Gen Genet. 1993;241:657-66 pubmed
The regulatory gene PDC2 was identified in a screen for mutations affecting pyruvate decarboxylase activity in yeast. I have cloned and sequenced this gene...
Velmurugan S, Lobo Z, Maitra P. Suppression of pdc2 regulating pyruvate decarboxylase synthesis in yeast. Genetics. 1997;145:587-94 pubmed
..We have isolated three different complementation groups of extragenic suppressors that suppress mutations in pdc2, a regulatory locus required for the synthesis of the glycolytic enzyme pyruvate decarboxylase...
Balciunas D, Hallberg M, Bjorklund S, Ronne H. Functional interactions within yeast mediator and evidence of differential subunit modifications. J Biol Chem. 2003;278:3831-9 pubmed
..Taken together, these results suggest that assembly of Mediator is a multistep process that involves conversion of both Med4 and Med8 to their low mobility forms. ..
Mojzita D, Hohmann S. Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mol Genet Genomics. 2006;276:147-61 pubmed
..In this work, we addressed the role of Pdc2 in the coordinated control of biosynthesis and demand of an essential metabolic cofactor, thiaminediphosphate (ThDP)..
Nosaka K, Onozuka M, Konno H, Akaji K. Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae. FEBS Lett. 2008;582:3991-6 pubmed publisher
..In this system, three proteins (Thi2p, Thi3p, and Pdc2p) act as positive regulatory factors...
Nosaka K, Esaki H, Onozuka M, Konno H, Hattori Y, Akaji K. Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation. FEMS Microbiol Lett. 2012;330:140-7 pubmed publisher
..Three positive regulatory factors (Thi2p, Thi3p, and Pdc2p) are involved in the expression of THI genes, whereas only Pdc2p is required for the expression of PDC5...