PCP1

Summary

Gene Symbol: PCP1
Description: rhomboid protease PCP1
Alias: MDM37, RBD1, rhomboid protease PCP1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Esser K, Tursun B, Ingenhoven M, Michaelis G, Pratje E. A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1. J Mol Biol. 2002;323:835-43 pubmed
    ..In addition, the Pcp1 (Ygr101w) gene product was found to be required for the second processing step, yielding the mature Ccp1 protein...
  2. Schäfer A, Zick M, Kief J, Steger M, Heide H, Duvezin Caubet S, et al. Intramembrane proteolysis of Mgm1 by the mitochondrial rhomboid protease is highly promiscuous regarding the sequence of the cleaved hydrophobic segment. J Mol Biol. 2010;401:182-93 pubmed publisher
    ..We investigated these requirements for the mitochondrial rhomboid protease Pcp1 and its substrate Mgm1...
  3. Bohovych I, Donaldson G, Christianson S, Zahayko N, Khalimonchuk O. Stress-triggered activation of the metalloprotease Oma1 involves its C-terminal region and is important for mitochondrial stress protection in yeast. J Biol Chem. 2014;289:13259-72 pubmed publisher
    ..These findings indicate that yeast Oma1 is an important player in IM protein homeostasis and integrity by acting in concert with other intramitochondrial quality control components. ..
  4. Kaouass M, Gamache I, Ramotar D, Audette M, Poulin R. The spermidine transport system is regulated by ligand inactivation, endocytosis, and by the Npr1p Ser/Thr protein kinase in Saccharomyces cerevisiae. J Biol Chem. 1998;273:2109-17 pubmed
    ..the initial velocity of spermidine uptake in wild-type cells as well as in the polyamine transport-deficient pcp1 mutants...
  5. Dimmer K, Fritz S, Fuchs F, Messerschmitt M, Weinbach N, Neupert W, et al. Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell. 2002;13:847-53 pubmed
    ..These data provide a comprehensive picture of the cellular processes and molecular components required for mitochondrial function and structure in a simple eukaryotic cell. ..
  6. Herlan M, Vogel F, Bornhovd C, Neupert W, Reichert A. Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem. 2003;278:27781-8 pubmed
    ..Furthermore, the conversion of l-Mgm1 into s-Mgm1 was found to be dependent on Pcp1 (Mdm37/YGR101w) a recently identified component essential for wild type mitochondrial morphology...
  7. McQuibban G, Saurya S, Freeman M. Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. Nature. 2003;423:537-41 pubmed
    ..Here we report that Saccharomyces cerevisiae has two rhomboids, which we have named Rbd1p and Rbd2p. RBD1 deletion results in a respiratory defect; consistent with this, Rbd1p is localized in the inner mitochondrial ..
  8. Sesaki H, Southard S, Hobbs A, Jensen R. Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion. Biochem Biophys Res Commun. 2003;308:276-83 pubmed
    ..Cell Biol. 152 (2001) 1123]. In this paper, we show that ugo2 mutants are defective in PCP1, a gene encoding a rhomboid-related serine protease...