Gene Symbol: PCL6
Species: Saccharomyces cerevisiae S288c
Measday V, Moore L, Retnakaran R, Lee J, Donoviel M, Neiman A, et al
. A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase. Mol Cell Biol. 1997;17:1212-23 pubmed
..We have named the other genes PCL5, PCL6, PCL7, PCL8, PCL9, and PCL10...
Tan Y, Morcos P, Cannon J. Pho85 phosphorylates the Glc7 protein phosphatase regulator Glc8 in vivo. J Biol Chem. 2003;278:147-53 pubmed
..The cyclin-dependent protein kinase, Pho85, in conjunction with the related cyclins Pcl6 and Pcl7 comprise the major Glc8 kinase in vivo and in vitro...
Jackson T, Kwon E, Chachulska A, Hyman L. Novel roles for elongin C in yeast. Biochim Biophys Acta. 2000;1491:161-76 pubmed
..This suggests a novel role for Elongin C and provides insights into additional potential functions in mammalian cells. ..
Wang Z, Wilson W, Fujino M, Roach P. The yeast cyclins Pc16p and Pc17p are involved in the control of glycogen storage by the cyclin-dependent protein kinase Pho85p. FEBS Lett. 2001;506:277-80 pubmed
..involved in the metabolism of the branched storage polysaccharide glycogen under certain conditions and deletion of PCL6 and PCL7 restores glycogen accumulation to a snf1 pcl8 pcl10 triple mutant, paradoxically activating both glycogen ..
Truman A, Kristjansdottir K, Wolfgeher D, Hasin N, Polier S, Zhang H, et al
. CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression. Cell. 2012;151:1308-18 pubmed publisher
..These results establish an active role for Hsp70 chaperones as signal transducers mediating growth control of G1 cyclin abundance and activity. ..