Gene Symbol: NTE1
Species: Saccharomyces cerevisiae S288c
Georgakopoulos T, Koutroubas G, Vakonakis I, Tzermia M, Prokova V, Voutsina A, et al
. Functional analysis of the Saccharomyces cerevisiae YFR021w/YGR223c/YPL100w ORF family suggests relations to mitochondrial/peroxisomal functions and amino acid signalling pathways. Yeast. 2001;18:1155-71 pubmed
..We found no unique phenotype attributed to the deletion of YGR223c. However, its function interferes with the function of the other two ORFs, as revealed by the effects of double- and triple-ORF deletions. ..
Zaccheo O, Dinsdale D, Meacock P, Glynn P. Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells. J Biol Chem. 2004;279:24024-33 pubmed
..We conclude that NTE and its homologues play a central role in membrane lipid homeostasis. ..
Murray J, McMaster C. Nte1p-mediated deacylation of phosphatidylcholine functionally interacts with Sec14p. J Biol Chem. 2005;280:8544-52 pubmed
..Sec14p acts as a positive regulator of Nte1p-mediated PC deacylation with the functional consequence of increased Nte1p activity increasing the permissive temperature for the growth of sec14(ts) cells. ..
Nunez L, Jesch S, Gaspar M, Almaguer C, Villa Garcia M, Ruiz Noriega M, et al
. Cell wall integrity MAPK pathway is essential for lipid homeostasis. J Biol Chem. 2008;283:34204-17 pubmed publisher
..Overexpression of the NTE1 phospholipase B gene suppresses the choline-sensitive inositol auxotrophy of mpk1Delta cells, whereas ..
Gulshan K, Moye Rowley W. Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1. Traffic. 2011;12:1257-68 pubmed publisher
..Our data describe a novel vacuolar route for lipid remodeling and reutilization in addition to previously described enzymatic avenues in the cytoplasm...
Fernández Murray J, Gaspard G, Jesch S, McMaster C. NTE1-encoded phosphatidylcholine phospholipase b regulates transcription of phospholipid biosynthetic genes. J Biol Chem. 2009;284:36034-46 pubmed publisher
The Saccharomyces cerevisiae NTE1 gene encodes an evolutionarily conserved phospholipase B localized to the endoplasmic reticulum (ER) that degrades phosphatidylcholine (PC) generating glycerophosphocholine and free fatty acids...