NPL6

Summary

Gene Symbol: NPL6
Description: Npl6p
Alias: RSC7, Npl6p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Cairns B, Schlichter A, Erdjument Bromage H, Tempst P, Kornberg R, Winston F. Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Mol Cell. 1999;4:715-23 pubmed
    ..Therefore, these domains are required for RSC function. Additional genetic analysis provides further evidence that RSC function is related to transcriptional control. ..
  2. Carey M, Li B, Workman J. RSC exploits histone acetylation to abrogate the nucleosomal block to RNA polymerase II elongation. Mol Cell. 2006;24:481-7 pubmed
    ..Thus, RSC can recognize acetylated nucleosomes and facilitate passage of Pol II through them. These data support the view that histone modifications regulate accessibility of the coding region to Pol II. ..
  3. Chambers A, Brownlee P, Durley S, Beacham T, Kent N, Downs J. The two different isoforms of the RSC chromatin remodeling complex play distinct roles in DNA damage responses. PLoS ONE. 2012;7:e32016 pubmed publisher
  4. Fischer C, Saha A, Cairns B. Kinetic model for the ATP-dependent translocation of Saccharomyces cerevisiae RSC along double-stranded DNA. Biochemistry. 2007;46:12416-26 pubmed
    ..These results are further discussed in the context of previously published studies of RSC and other DNA translocases. ..
  5. Oum J, Seong C, Kwon Y, Ji J, Sid A, Ramakrishnan S, et al. RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks. Mol Cell Biol. 2011;31:3924-37 pubmed publisher
    ..This study provides molecular insights into how chromatin remodeling contributes to DNA repair and maintenance of chromatin fidelity in the face of DNA damage. ..
  6. Andress E, Holic R, Edelmann M, Kessler B, Yu V. Dia2 controls transcription by mediating assembly of the RSC complex. PLoS ONE. 2011;6:e21172 pubmed publisher
    ..Dia2, by controlling the RSC chromatin remodeller, fine-tunes transcription by controlling nucleosome positioning during transcriptional activation and repression. ..
  7. Sadler I, Chiang A, Kurihara T, Rothblatt J, Way J, Silver P. A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein. J Cell Biol. 1989;109:2665-75 pubmed
    ..Thus, NPL1/SEC63 may act at a very early common step in localization of proteins to the nucleus and the ER. Alternatively, by affecting ER and nuclear envelope assembly, npl1 may indirectly alter assembly of proteins into the nucleus. ..
  8. Chang M, Bellaoui M, Boone C, Brown G. A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A. 2002;99:16934-9 pubmed
    ..These genes may promote replication fork stability or processivity during encounters between replication forks and DNA damage. ..
  9. Zhang Y, Smith C, Saha A, Grill S, Mihardja S, Smith S, et al. DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Mol Cell. 2006;24:559-68 pubmed
    ..Such loop formation may provide a molecular basis for the biological functions of remodelers. ..

More Information

Publications18

  1. Ferreira H, Flaus A, Owen Hughes T. Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms. J Mol Biol. 2007;374:563-79 pubmed
    ..These observations illustrate a range of different means by which modifications to histones can influence the action of remodelling enzymes. ..
  2. Partensky P, Narlikar G. Chromatin remodelers act globally, sequence positions nucleosomes locally. J Mol Biol. 2009;391:12-25 pubmed publisher
    ..However, consequent to the rate-limiting remodeling step, the local DNA sequence promotes a collapse of remodeling intermediates into highly resolved positions that are dictated by thermodynamic differences between adjacent positions. ..
  3. Saha A, Wittmeyer J, Cairns B. Chromatin remodeling by RSC involves ATP-dependent DNA translocation. Genes Dev. 2002;16:2120-34 pubmed
    ..Nucleosomes bearing nicks are remodeled less efficiently than intact nucleosomes. These results suggest that RSC and Sth1 are DNA translocases that use both DNA translocation and twist to remodel nucleosomes efficiently. ..
  4. Damelin M, Simon I, Moy T, Wilson B, Komili S, Tempst P, et al. The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress. Mol Cell. 2002;9:563-73 pubmed
    ..Our results illustrate the response of a chromatin-remodeling factor to signaling cascades and suggest that changes in the activity of chromatin-remodeling factors are reflected in changes in their localization in the genome. ..
  5. Parnell T, Schlichter A, WILSON B, Cairns B. The chromatin remodelers RSC and ISW1 display functional and chromatin-based promoter antagonism. elife. 2015;4:e06073 pubmed publisher
    ..Taken together, we provide the first genetic and genomic evidence for RSC-ISW1a antagonism and reveal different mechanisms at two different promoter architectures. ..
  6. Lorch Y, Maier Davis B, Kornberg R. Chromatin remodeling by nucleosome disassembly in vitro. Proc Natl Acad Sci U S A. 2006;103:3090-3 pubmed
    ..RSC and related chromatin-remodeling complexes may be responsible for the removal of promoter nucleosomes during transcriptional activation in vivo. ..
  7. Lia G, Praly E, Ferreira H, Stockdale C, Tse Dinh Y, Dunlap D, et al. Direct observation of DNA distortion by the RSC complex. Mol Cell. 2006;21:417-25 pubmed
    ..These observations support the idea that the ATPase motors of the Snf2 family of proteins act as DNA translocases specialized to generate transient distortions in DNA structure. ..
  8. Smart S, Mackintosh S, Edmondson R, Taverna S, Tackett A. Mapping the local protein interactome of the NuA3 histone acetyltransferase. Protein Sci. 2009;18:1987-97 pubmed publisher
    ..These novel, physical associations with yFACT, RSC, and Nap1 provide insight into the mechanism of NuA3-associated transcription and chromatin regulation. ..
  9. Echtenkamp F, Gvozdenov Z, Adkins N, Zhang Y, Lynch Day M, Watanabe S, et al. Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler. Mol Cell. 2016;64:888-899 pubmed publisher
    ..In the case of RSC, p23 and Hsp90 promote a dynamic action, allowing a limited number of remodelers to effectively maintain chromatin in a pliable state. ..