Gene Symbol: NOP53
Species: Saccharomyces cerevisiae S288c
Bassler J, Grandi P, Gadal O, Lessmann T, Petfalski E, Tollervey D, et al
. Identification of a 60S preribosomal particle that is closely linked to nuclear export. Mol Cell. 2001;8:517-29 pubmed
..Eight of these proteins were copurified with nuclear pore complexes, suggesting that this complex represents the transport intermediate for 60S subunit export. ..
Sydorskyy Y, Dilworth D, Halloran B, Yi E, Makhnevych T, Wozniak R, et al
. Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein. Biochem J. 2005;388:819-26 pubmed
..In the present study we demonstrate a crucial role for the previously uncharacterized nucleolar protein Nop53p (Ypl146p) in ribosome biogenesis...
Granato D, Gonzales F, Luz J, Cassiola F, Machado Santelli G, Oliveira C. Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae. FEBS J. 2005;272:4450-63 pubmed
..A novel nucleolar protein, Nop53p, was isolated by using Nop17p as bait in the yeast two-hybrid system...
Matsuo Y, Granneman S, Thoms M, Manikas R, Tollervey D, Hurt E. Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export. Nature. 2014;505:112-116 pubmed publisher
..We conclude that Nug2 is a regulatory GTPase that monitors pre-60S maturation, with release from its placeholder site linked to recruitment of the nuclear export machinery. ..
Thomson E, Tollervey D. Nop53p is required for late 60S ribosome subunit maturation and nuclear export in yeast. RNA. 2005;11:1215-24 pubmed
We report that Ypl146cp/Nop53p is associated with pre-60S ribosomal complexes and localized to the nucleolus and nucleoplasm...
Granato D, Machado Santelli G, Oliveira C. Nop53p interacts with 5.8S rRNA co-transcriptionally, and regulates processing of pre-rRNA by the exosome. FEBS J. 2008;275:4164-78 pubmed publisher
..The yeast nucleolar protein Nop53p has previously been identified in the pre-60S complex and shown to affect pre-rRNA processing by directly binding ..
Thoms M, Thomson E, BaÃŸler J, GnÃ¤dig M, Griesel S, Hurt E. The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins. Cell. 2015;162:1029-38 pubmed publisher
..b>Nop53, the yeast homolog of the tumor suppressor PICT1, targets Mtr4 to pre-ribosomal particles for exosome-mediated ..
Falk S, Tants J, Basquin J, Thoms M, Hurt E, Sattler M, et al
. Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53. RNA. 2017;23:1780-1787 pubmed publisher
..i>S. cerevisiae Mtr4 interacts directly with Nop53, a ribosomal biogenesis factor present in late pre-60S particles containing precursors of the 5.8S rRNA...