Gene Symbol: NOC2
Description: mRNA-binding ribosome synthesis protein NOC2
Alias: mRNA-binding ribosome synthesis protein NOC2
Species: Saccharomyces cerevisiae S288c
Milkereit P, Gadal O, Podtelejnikov A, Trumtel S, Gas N, Petfalski E, et al
. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Cell. 2001;105:499-509 pubmed
..We propose that the dynamic interaction of Noc proteins is crucial for intranuclear movement of ribosomal precursor particles, and, thereby represent a prerequisite for proper maturation. ..
Milkereit P, Strauss D, Bassler J, Gadal O, Kühn H, Schütz S, et al
. A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits. J Biol Chem. 2003;278:4072-81 pubmed
Formation and nuclear export of 60 S pre-ribosomes requires many factors including the heterodimeric Noc1-Noc2 and Noc2-Noc3 complexes. Here, we report another Noc complex with a specific role in 40 S subunit biogenesis...
Miles T, Jakovljevic J, Horsey E, Harnpicharnchai P, Tang L, Woolford J. Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes. Mol Cell Biol. 2005;25:10419-32 pubmed
..Mutations in the WD40 motifs of Ytm1 disrupt binding to Erb1, destabilize the heterotrimer, and delay pre-rRNA processing and nuclear export of preribosomes. Nevertheless, 66S preribosomes lacking Ytm1 remain otherwise intact. ..
Bassler J, Kallas M, Hurt E. The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles. J Biol Chem. 2006;281:24737-44 pubmed
..Nug1-N exhibits RNA binding activity and is genetically linked in an allele-specific way to the pre-60 S factors Noc2, Noc3, and Dbp10...
Bassler J, Grandi P, Gadal O, Lessmann T, Petfalski E, Tollervey D, et al
. Identification of a 60S preribosomal particle that is closely linked to nuclear export. Mol Cell. 2001;8:517-29 pubmed
..Eight of these proteins were copurified with nuclear pore complexes, suggesting that this complex represents the transport intermediate for 60S subunit export. ..
Volta V, Ceci M, Emery B, Bachi A, Petfalski E, Tollervey D, et al
. Sen34p depletion blocks tRNA splicing in vivo and delays rRNA processing. Biochem Biophys Res Commun. 2005;337:89-94 pubmed
..Finally, we confirm that Tif6p accompanies 27S pre-rRNA maturation to 25S rRNA and we suggest that Sen34p endonuclease in Tif6p complex may affect also rRNA maturation. ..
Merl J, Jakob S, Ridinger K, Hierlmeier T, Deutzmann R, Milkereit P, et al
. Analysis of ribosome biogenesis factor-modules in yeast cells depleted from pre-ribosomes. Nucleic Acids Res. 2010;38:3068-80 pubmed publisher
..The data presented strengthen the idea that assembly of eukaryotic pre-ribosomal particles can result from transient association of distinct building blocks. ..
McCann K, Teramoto T, Zhang J, Tanaka Hall T, Baserga S. The molecular basis for ANE syndrome revealed by the large ribosomal subunit processome interactome. elife. 2016;5: pubmed publisher