Gene Symbol: NDE2
Description: NADH-ubiquinone reductase (H(+)-translocating) NDE2
Alias: NDH2, NADH-ubiquinone reductase (H(+)-translocating) NDE2
Species: Saccharomyces cerevisiae S288c
Small W, McAlister Henn L. Identification of a cytosolically directed NADH dehydrogenase in mitochondria of Saccharomyces cerevisiae. J Bacteriol. 1998;180:4051-5 pubmed
..Disruption of a closely related gene designated NDH2 has no effect on these properties...
Luttik M, Overkamp K, Kotter P, de Vries S, van Dijken J, Pronk J. The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH. J Biol Chem. 1998;273:24529-34 pubmed
..To investigate whether open reading frames YMR145c/NDE1 and YDL 085w/NDE2, which exhibit sequence similarity with NDI1, encode the latter enzyme, NADH-dependent mitochondrial respiration ..
Overkamp K, Bakker B, Kotter P, van Tuijl A, de Vries S, van Dijken J, et al
. In vivo analysis of the mechanisms for oxidation of cytosolic NADH by Saccharomyces cerevisiae mitochondria. J Bacteriol. 2000;182:2823-30 pubmed
Grandier Vazeille X, Bathany K, Chaignepain S, Camougrand N, Manon S, Schmitter J. Yeast mitochondrial dehydrogenases are associated in a supramolecular complex. Biochemistry. 2001;40:9758-69 pubmed
..The association of these proteins is discussed in terms of NADH-channeling. ..
Pahlman I, Larsson C, Avéret N, Bunoust O, Boubekeur S, Gustafsson L, et al
. Kinetic regulation of the mitochondrial glycerol-3-phosphate dehydrogenase by the external NADH dehydrogenase in Saccharomyces cerevisiae. J Biol Chem. 2002;277:27991-5 pubmed
..The physiological consequences of this regulation are discussed. ..
Menacho MÃ¡rquez M, RodrÃguez HernÃ¡ndez C, Villaronga M, PÃ©rez Valle J, Gadea J, Belandia B, et al
. eIF2 kinases mediate Î²-lapachone toxicity in yeast and human cancer cells. Cell Cycle. 2015;14:630-40 pubmed publisher
..Most interestingly, DNA damage responses triggered by Î²-lap were abolished in the nde2Î” mutant...
Overkamp K, Bakker B, Kötter P, Luttik M, van Dijken J, Pronk J. Metabolic engineering of glycerol production in Saccharomyces cerevisiae. Appl Environ Microbiol. 2002;68:2814-21 pubmed
..To test this hypothesis, a tpi1delta nde1delta nde2delta gut2delta quadruple mutant was constructed. NDE1 and NDE2 encode isoenzymes of mitochondrial external NADH dehydrogenase; GUT2 encodes a key enzyme of the glycerol-3-..