Gene Symbol: NDE1
Description: NADH-ubiquinone reductase (H(+)-translocating) NDE1
Alias: NDH1, NADH-ubiquinone reductase (H(+)-translocating) NDE1
Species: Saccharomyces cerevisiae S288c
Small W, McAlister Henn L. Identification of a cytosolically directed NADH dehydrogenase in mitochondria of Saccharomyces cerevisiae. J Bacteriol. 1998;180:4051-5 pubmed
..Disruption of the gene designated NDH1 results in a threefold reduction in total mitochondrial NADH dehydrogenase activity in cells cultivated with ..
Overkamp K, Bakker B, Kotter P, van Tuijl A, de Vries S, van Dijken J, et al
. In vivo analysis of the mechanisms for oxidation of cytosolic NADH by Saccharomyces cerevisiae mitochondria. J Bacteriol. 2000;182:2823-30 pubmed
Pahlman I, Larsson C, Avéret N, Bunoust O, Boubekeur S, Gustafsson L, et al
. Kinetic regulation of the mitochondrial glycerol-3-phosphate dehydrogenase by the external NADH dehydrogenase in Saccharomyces cerevisiae. J Biol Chem. 2002;277:27991-5 pubmed
..The physiological consequences of this regulation are discussed. ..
Li W, Sun L, Liang Q, Wang J, Mo W, Zhou B. Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Mol Biol Cell. 2006;17:1802-11 pubmed
..overexpression of yeast AMID homologue internal NADH dehydrogenase (NDI1), but not external NADH dehydrogenase (NDE1), can cause apoptosis-like cell death, and this effect can be repressed by increased respiration on glucose-limited ..
Bricker D, Taylor E, Schell J, Orsak T, Boutron A, Chen Y, et al
. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science. 2012;337:96-100 pubmed publisher
..These data demonstrate that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier. ..
Luttik M, Overkamp K, Kotter P, de Vries S, van Dijken J, Pronk J. The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH. J Biol Chem. 1998;273:24529-34 pubmed
..To investigate whether open reading frames YMR145c/NDE1 and YDL 085w/NDE2, which exhibit sequence similarity with NDI1, encode the latter enzyme, NADH-dependent ..
Lauffer S, Mäbert K, Czupalla C, Pursche T, Hoflack B, Rödel G, et al
. Saccharomyces cerevisiae porin pore forms complexes with mitochondrial outer membrane proteins Om14p and Om45p. J Biol Chem. 2012;287:17447-58 pubmed publisher
..We propose a model for the role of the two OM proteins in addressing the porin pore to bind to specific channels in the mt IM to facilitate transport of metabolites. ..
Overkamp K, Bakker B, Kötter P, Luttik M, van Dijken J, Pronk J. Metabolic engineering of glycerol production in Saccharomyces cerevisiae. Appl Environ Microbiol. 2002;68:2814-21 pubmed
..To test this hypothesis, a tpi1delta nde1delta nde2delta gut2delta quadruple mutant was constructed. NDE1 and NDE2 encode isoenzymes of mitochondrial external NADH dehydrogenase; GUT2 encodes a key enzyme of the glycerol-..
Gomes F, Tahara E, Busso C, Kowaltowski A, Barros M. nde1 deletion improves mitochondrial DNA maintenance in Saccharomyces cerevisiae coenzyme Q mutants. Biochem J. 2013;449:595-603 pubmed publisher
..Interestingly, nde1 deletion was protective for mtDNA in strains defective in CoQ function...