Gene Symbol: NCR1
Description: sphingolipid transporter
Alias: sphingolipid transporter
Species: Saccharomyces cerevisiae S288c
Malathi K, Higaki K, Tinkelenberg A, Balderes D, Almanzar Paramio D, Wilcox L, et al
. Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution. J Cell Biol. 2004;164:547-56 pubmed
..Expression of yeast NP-C-related gene 1 (NCR1), the orthologue of the human NP-C gene 1 (NPC1) defective in the disease, in Chinese hamster ovary NPC1 mutant ..
Berger A, Hanson P, Wylie Nichols J, Corbett A. A yeast model system for functional analysis of the Niemann-Pick type C protein 1 homolog, Ncr1p. Traffic. 2005;6:907-17 pubmed
..This study focuses on the Saccharomyces cerevisiae homolog of the human NPC1 protein encoded by the NCR1 gene. Ncr1p localizes to the vacuole, the yeast equivalent to the mammalian endosome-lysosome system...
Vilaça R, Silva E, Nadais A, Teixeira V, Matmati N, Gaifem J, et al
. Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1. Mol Microbiol. 2014;91:438-51 pubmed publisher
..cells displayed high levels of long chain bases (LCB), and that Sch9p-phospho-T570 and Sch9p levels increased in ncr1? cells through a mechanism regulated by Pkh1p, a LCB-activated protein kinase...
De Block J, Szopinska A, Guerriat B, Dodzian J, Villers J, Hochstenbach J, et al
. Yeast Pmp3p has an important role in plasma membrane organization. J Cell Sci. 2015;128:3646-59 pubmed publisher
..These genetic interactions, together with lipid binding assays and epifluorescence microscopy, as well as other biochemical experiments, suggest that Pmp3p could be part of a phosphoinositide-regulated stress sensor. ..
Tsuji T, Fujimoto M, Tatematsu T, Cheng J, Orii M, Takatori S, et al
. Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole. elife. 2017;6: pubmed publisher
..These data show that NPC proteins promote microautophagy in stationary phase and under nitrogen starvation conditions, likely by increasing sterol in the limiting membrane of the vacuole. ..