Gene Symbol: NAR1
Species: Saccharomyces cerevisiae S288c
Barton R, Worman H. Prenylated prelamin A interacts with Narf, a novel nuclear protein. J Biol Chem. 1999;274:30008-18 pubmed
..The prenyl-dependent binding of Narf to prelamin A is an important first step in understanding the functional significance of the lamin A precursor. ..
Hausmann A, Aguilar Netz D, Balk J, Pierik A, Muhlenhoff U, Lill R. The eukaryotic P loop NTPase Nbp35: an essential component of the cytosolic and nuclear iron-sulfur protein assembly machinery. Proc Natl Acad Sci U S A. 2005;102:3266-71 pubmed
..Furthermore, Nbp35p genetically interacts with the closely similar P loop NTPase, Cfd1p, and the hydrogenase-like Nar1p, both of which were recently shown to perform a crucial function in cytosolic and nuclear Fe/S protein biogenesis...
Balk J, Aguilar Netz D, Tepper K, Pierik A, Lill R. The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly. Mol Cell Biol. 2005;25:10833-41 pubmed
..three recently identified extramitochondrial proteins, the P-loop NTPases Cfd1 and Nbp35 and the hydrogenase-like Nar1. However, the molecular mechanism of Fe/S protein assembly in the cytosol is far from being understood, and more ..
Urzica E, Pierik A, Muhlenhoff U, Lill R. Crucial role of conserved cysteine residues in the assembly of two iron-sulfur clusters on the CIA protein Nar1. Biochemistry. 2009;48:4946-58 pubmed publisher
..The CIA protein Nar1 performs a specific function in transferring an Fe/S cluster that is assembled de novo on the Cfd1-Nbp35 scaffold ..
Balk J, Pierik A, Netz D, Muhlenhoff U, Lill R. The hydrogenase-like Nar1p is essential for maturation of cytosolic and nuclear iron-sulphur proteins. EMBO J. 2004;23:2105-15 pubmed
The genome of the yeast Saccharomyces cerevisiae encodes the essential protein Nar1p that is conserved in virtually all eukaryotes and exhibits striking sequence similarity to bacterial iron-only hydrogenases...
Yarunin A, Panse V, Petfalski E, Dez C, Tollervey D, Hurt E. Functional link between ribosome formation and biogenesis of iron-sulfur proteins. EMBO J. 2005;24:580-8 pubmed
In genetic screens for ribosomal export mutants, we identified CFD1, NBP35 and NAR1 as factors involved in ribosome biogenesis...
Fujii M, Adachi N, Shikatani K, Ayusawa D. [FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode. Genes Cells. 2009;14:457-68 pubmed publisher
..4). In the yeast Saccharomyces cerevisiae, a deletion of NAR1, a possible homologue of oxy-4, also caused a similar increased sensitivity to oxygen...
Netz D, Stümpfig M, Dore C, Muhlenhoff U, Pierik A, Lill R. Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. Nat Chem Biol. 2010;6:758-65 pubmed publisher
..The pathway is conserved in eukaryotes, as human Ndor1-Ciapin1 proteins can functionally replace yeast Tah18-Dre2. ..
Zhao W, Fang B, Niu Y, Liu Y, Liu B, Peng Q, et al
. Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. Mech Ageing Dev. 2014;138:53-8 pubmed publisher
Saccharomyces cerevisiae Nar1p is an essential Fe/S protein that exhibits striking similarity to bacterial iron-only hydrogenases...