Gene Symbol: MXR2
Species: Saccharomyces cerevisiae S288c
Allu P, Marada A, Boggula Y, Karri S, Krishnamoorthy T, Sepuri N. Methionine sulfoxide reductase 2 reversibly regulates Mge1, a cochaperone of mitochondrial Hsp70, during oxidative stress. Mol Biol Cell. 2015;26:406-19 pubmed publisher
..By using Saccharomyces cerevisiae as a model, we show that of the two methionine sulfoxide reductases (MXR1, MXR2), deletion of mitochondrial MXR2 renders yeast cells more sensitive to oxidative stress than the cytosolic MXR1...
Le D, Lee B, Marino S, Zhang Y, Fomenko D, Kaya A, et al
. Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae. J Biol Chem. 2009;284:4354-64 pubmed publisher
..The data show that fRMsr is the main enzyme responsible for the reduction of free Met-R-SO in S. cerevisiae. ..
Kryukov G, Kumar R, Koc A, Sun Z, Gladyshev V. Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase. Proc Natl Acad Sci U S A. 2002;99:4245-50 pubmed
Koc A, Gasch A, Rutherford J, Kim H, Gladyshev V. Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. Proc Natl Acad Sci U S A. 2004;101:7999-8004 pubmed
..The data also suggest a model wherein factors implicated in aging (for example, ROS) may influence the lifespan yet not be the cause of aging. ..
Kaya A, Koc A, Lee B, Fomenko D, Rederstorff M, Krol A, et al
. Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast. Biochemistry. 2010;49:8618-25 pubmed publisher
..These results show that oxidative stress contributes to mitochondrial dysfunction through oxidation of methionine residues in proteins located in different cellular compartments. ..