Gene Symbol: MVB12
Description: ubiquitin-binding ESCRT-I subunit protein MVB12
Alias: ubiquitin-binding ESCRT-I subunit protein MVB12
Species: Saccharomyces cerevisiae S288c
Curtiss M, Jones C, Babst M. Efficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12. Mol Biol Cell. 2007;18:636-45 pubmed
..We identified an additional subunit of yeast ESCRT-I called Mvb12, which seems to associate with ESCRT-I by binding to Vps37...
Chu T, Sun J, Saksena S, Emr S. New component of ESCRT-I regulates endosomal sorting complex assembly. J Cell Biol. 2006;175:815-23 pubmed
..We identify a new component of the ESCRT-I complex, multivesicular body sorting factor of 12 kD (Mvb12), and demonstrate that Mvb12 binds to the coiled-coil domain of the ESCRT-I subunit vacuolar protein sorting 23 (..
Oestreich A, Davies B, Payne J, Katzmann D. Mvb12 is a novel member of ESCRT-I involved in cargo selection by the multivesicular body pathway. Mol Biol Cell. 2007;18:646-57 pubmed
..genetic screen to identify novel factors required for cargo-specific selection by this pathway and identified the Mvb12 protein. Loss of Mvb12 function results in differential defects in the selection of MVB cargoes...
Kostelansky M, Schluter C, Tam Y, Lee S, Ghirlando R, Beach B, et al
. Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell. 2007;129:485-98 pubmed
..Yeast ESCRT-I contains four subunits, Vps23, Vps28, Vps37, and Mvb12. The crystal structure of the heterotetrameric ESCRT-I complex reveals a highly asymmetric complex of 1:1:1:1 ..
Shields S, Oestreich A, Winistorfer S, Nguyen D, Payne J, Katzmann D, et al
. ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting. J Cell Biol. 2009;185:213-24 pubmed publisher
..These experiments reveal an unexpected level of coordination among the ESCRT UBDs, suggesting that they collectively recognize a diverse set of cargo rather than act sequentially at discrete steps. ..
Peters T, Miller A, Tourette C, Agren H, Hubbard A, Hughes R. Genomic Analysis of ATP Efflux in Saccharomyces cerevisiae. G3 (Bethesda). 2015;6:161-70 pubmed publisher
..These results will facilitate analysis of ATP efflux mechanisms in higher eukaryotes. ..