MUK1

Summary

Gene Symbol: MUK1
Description: guanine nucleotide exchange factor MUK1
Alias: guanine nucleotide exchange factor MUK1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Paulsel A, Merz A, Nickerson D. Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast. J Biol Chem. 2013;288:18162-71 pubmed publisher
    ..Here, we show that Muk1, which also contains a VPS9 domain, acts as a second GEF against Vps21, Ypt52, and Ypt53...
  2. Bean B, Davey M, Snider J, Jessulat M, Deineko V, Tinney M, et al. Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes. Mol Biol Cell. 2015;26:1119-28 pubmed publisher
    ..retromer and the Saccharomyces cerevisiae VPS9-domain Rab5-family guanine nucleotide exchange factors (GEFs) Muk1 and Vps9...
  3. Shideler T, Nickerson D, Merz A, Odorizzi G. Ubiquitin binding by the CUE domain promotes endosomal localization of the Rab5 GEF Vps9. Mol Biol Cell. 2015;26:1345-56 pubmed publisher
    Vps9 and Muk1 are guanine nucleotide exchange factors (GEFs) in Saccharomyces cerevisiae that regulate membrane trafficking in the endolysosomal pathway by activating Rab5 GTPases...
  4. Cabrera M, Arlt H, Epp N, Lachmann J, Griffith J, Perz A, et al. Functional separation of endosomal fusion factors and the class C core vacuole/endosome tethering (CORVET) complex in endosome biogenesis. J Biol Chem. 2013;288:5166-75 pubmed publisher
    ..In this context, we also uncover that Muk1 can compensate for loss of Vps9 in CORVET localization, indicating that two Rab5 guanine nucleotide exchange ..
  5. Cabrera M, Ungermann C. Guanine nucleotide exchange factors (GEFs) have a critical but not exclusive role in organelle localization of Rab GTPases. J Biol Chem. 2013;288:28704-12 pubmed publisher
    ..Our data agree with the emerging model that GEFs are critical for Rab localization but raise the possibility that additional factors can contribute to this process...