Gene Symbol: MTL1
Description: Mtl1p
Alias: Mtl1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Sekiya Kawasaki M, Abe M, Saka A, Watanabe D, Kono K, Minemura Asakawa M, et al. Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae. Genetics. 2002;162:663-76 pubmed
    ..We demonstrate that all of the multicopy suppressors obtained (WSC1, WSC3, MTL1, ROM2, LRE1, ZDS1, and MSB1) and the constitutively active RHO1 mutations tested restore 1,3-beta-glucan synthesis ..
  2. Vilella F, Herrero E, Torres J, De La Torre Ruiz M. Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. J Biol Chem. 2005;280:9149-59 pubmed
    ..b>Mtl1 is characterized for the first time as a cell-wall sensor of oxidative stress...
  3. Rajavel M, Philip B, Buehrer B, Errede B, Levin D. Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol Cell Biol. 1999;19:3969-76 pubmed
    ..Finally, we identified a yeast homolog of MID2, designated MTL1, which provides a partially redundant function with MID2 for cell integrity signaling during vegetative growth at ..
  4. Petkova M, Pujol Carrion N, Arroyo J, GarcĂ­a Cantalejo J, Angeles de la Torre Ruiz M. Mtl1 is required to activate general stress response through Tor1 and Ras2 inhibition under conditions of glucose starvation and oxidative stress. J Biol Chem. 2010;285:19521-31 pubmed publisher
    b>Mtl1 is a member of the cell wall integrity (CWI) pathway of Saccharomyces cerevisiae, which functions as a cell wall sensor for oxidative stress...
  5. Petkova M, Pujol Carrion N, De La Torre Ruiz M. Mtl1 O-mannosylation mediated by both Pmt1 and Pmt2 is important for cell survival under oxidative conditions and TOR blockade. Fungal Genet Biol. 2012;49:903-14 pubmed publisher
    b>Mtl1 is a cell surface sensor and member of the Pkc1-MAPK pathway that senses oxidative stress and nutrient starvation...
  6. Ketela T, Green R, Bussey H. Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol. 1999;181:3330-40 pubmed
    ..In addition, we have identified an open reading frame, MTL1, which encodes a protein with both structural and functional similarity to Mid2p.
  7. de Bettignies G, Thoraval D, Morel C, Peypouquet M, Crouzet M. Overactivation of the protein kinase C-signaling pathway suppresses the defects of cells lacking the Rho3/Rho4-GAP Rgd1p in Saccharomyces cerevisiae. Genetics. 2001;159:1435-48 pubmed
    ..encoding two small GTPases, MKK1 encoding one of the MAP-kinase kinases in the protein kinase C (PKC) pathway, and MTL1, a MID2-homolog, were shown to suppress the rgd1Delta defects strengthening the functional links between RGD1 and ..
  8. Zanelli C, Valentini S. Pkc1 acts through Zds1 and Gic1 to suppress growth and cell polarity defects of a yeast eIF5A mutant. Genetics. 2005;171:1571-81 pubmed
    ..Taken together, these data strongly support the correlated involvement of Pkc1 and eIF5A in establishing actin polarity, which is essential for bud formation and G1/S transition in S. cerevisiae. ..
  9. Mauchi N, Ohtake Y, Irie K. Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeast. Cell Struct Funct. 2010;35:95-105 pubmed
    ..mRNA targets including a bud-localized ASH1 mRNA and mRNAs encoding membrane-associated proteins such as Mid2p and Mtl1p. While Khd1p negatively regulates gene expression of Ash1p by translational repression, Khd1p positively regulates ..

More Information


  1. Petkova M, Pujol Carrion N, De La Torre Ruiz M. Signal flow between CWI/TOR and CWI/RAS in budding yeast under conditions of oxidative stress and glucose starvation. Commun Integr Biol. 2010;3:555-7 pubmed publisher
    The CWI pathway cross-talks with TOR and RAS in both the oxidative and glucose starvation responses. Mtl1 is the cell-wall protein in charge of sensing and regulating this response...
  2. Jin C, Parshin A, Daly I, Strich R, Cooper K. The cell wall sensors Mtl1, Wsc1, and Mid2 are required for stress-induced nuclear to cytoplasmic translocation of cyclin C and programmed cell death in yeast. Oxid Med Cell Longev. 2013;2013:320823 pubmed publisher
    b>Mtl1 is a member of a cell wall sensor family that monitors cell wall integrity in budding yeast...
  3. Sundaram V, Petkova M, Pujol Carrion N, Boada J, De La Torre Ruiz M. Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival. Mol Microbiol. 2015;97:93-109 pubmed publisher
    Here we show that Mtl1, member of the cell wall integrity pathway of Saccharomyces cerevisiae, plays a positive role in chronological life span (CLS). The absence of Mtl1 shortens CLS and causes impairment in the mitochondrial function...