MSO1

Summary

Gene Symbol: MSO1
Description: Mso1p
Alias: Mso1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Castillo Flores A, Weinberger A, Robinson M, Gerst J. Mso1 is a novel component of the yeast exocytic SNARE complex. J Biol Chem. 2005;280:34033-41 pubmed
    ..Another protein, Sec1, binds to the SNARE complex to facilitate assembly. We show that Mso1, a Sec1-interacting protein, also binds to the SNARE complex and plays a role in mediating Sec1 functions...
  2. Aalto M, Jantti J, Ostling J, Keranen S, Ronne H. Mso1p: a yeast protein that functions in secretion and interacts physically and genetically with Sec1p. Proc Natl Acad Sci U S A. 1997;94:7331-6 pubmed
    ..We further found that Mso1p interacts with Sec1p both in vitro and in the two-hybrid system...
  3. Knop M, Miller K, Mazza M, Feng D, Weber M, Keränen S, et al. Molecular interactions position Mso1p, a novel PTB domain homologue, in the interface of the exocyst complex and the exocytic SNARE machinery in yeast. Mol Biol Cell. 2005;16:4543-56 pubmed
    In this study, we have analyzed the association of the Sec1p interacting protein Mso1p with the membrane fusion machinery in yeast. We show that Mso1p is essential for vesicle fusion during prospore membrane formation...
  4. Brummer M, Kivinen K, Jantti J, Toikkanen J, Soderlund H, Keranen S. Characterization of the sec1-1 and sec1-11 mutations. Yeast. 2001;18:1525-36 pubmed
    ..The mutant proteins were unable to interact with the Sec1p-interacting proteins Mso1p and Sso2p in the two-hybrid assay, even at the permissive temperature...
  5. Jantti J, Aalto M, Oyen M, Sundqvist L, Keränen S, Ronne H. Characterization of temperature-sensitive mutations in the yeast syntaxin 1 homologues Sso1p and Sso2p, and evidence of a distinct function for Sso1p in sporulation. J Cell Sci. 2002;115:409-20 pubmed
    ..The sso1-1 mutation interacts synthetically with a disruption of the MSO1 gene, which encodes a Sec1p interacting protein...
  6. Weber M, Chernov K, Turakainen H, Wohlfahrt G, Pajunen M, Savilahti H, et al. Mso1p regulates membrane fusion through interactions with the putative N-peptide-binding area in Sec1p domain 1. Mol Biol Cell. 2010;21:1362-74 pubmed publisher
    ..We previously identified Mso1p as a Sec1p-binding protein and showed that it is involved in membrane fusion regulation...
  7. Weber Boyvat M, Aro N, Chernov K, Nyman T, Jantti J. Sec1p and Mso1p C-terminal tails cooperate with the SNAREs and Sec4p in polarized exocytosis. Mol Biol Cell. 2011;22:230-44 pubmed publisher
    ..fluorescence complementation (BiFC) assay results suggest that, in the SNARE-deficient sso2-1 ?sso1 cells, Mso1p, a Sec1p binding protein, helps to target Sec1p(1-657) lacking the C-terminal tail to the sites of secretion...
  8. Weber Boyvat M, Zhao H, Aro N, Yuan Q, Chernov K, Peranen J, et al. A conserved regulatory mode in exocytic membrane fusion revealed by Mso1p membrane interactions. Mol Biol Cell. 2013;24:331-41 pubmed publisher
    ..We provide evidence that Mso1p, a Sec1p- and Sec4p-binding protein, interacts with membranes to regulate membrane fusion...