MSN2

Summary

Gene Symbol: MSN2
Description: stress-responsive transcriptional activator MSN2
Alias: stress-responsive transcriptional activator MSN2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Gasch A, Spellman P, Kao C, Carmel Harel O, Eisen M, Storz G, et al. Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell. 2000;11:4241-57 pubmed
    ..Physiological themes in the genomic responses to specific environmental stresses provided insights into the effects of those stresses on the cell...
  2. Petrenko N, Chereji R, McClean M, Morozov A, Broach J. Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses. Mol Biol Cell. 2013;24:2045-57 pubmed publisher
    ..Yeast cells sense stress through diverse signaling pathways that converge on the transcription factors Msn2 and Msn4, which respond by initiating rapid, idiosyncratic cycles into and out of the nucleus...
  3. Fabrizio P, Pletcher S, Minois N, Vaupel J, Longo V. Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. FEBS Lett. 2004;557:136-42 pubmed
    ..However, the triple deletion of stress-resistance genes MSN2/MSN4 and RIM15, which causes a major decrease in chronological life span, extends replicative life span...
  4. Santhanam A, Hartley A, Düvel K, Broach J, Garrett S. PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p. Eukaryot Cell. 2004;3:1261-71 pubmed
    ..Finally, Msn2p localization is unaffected by conditional loss of 14-3-3 protein function, ruling out the possibility that 14-3-3 proteins act as a scaffold to sequester Msn2p in the cytoplasm. ..
  5. Boy Marcotte E, Garmendia C, Garreau H, Lallet S, Mallet L, Jacquet M. The transcriptional activation region of Msn2p, in Saccharomyces cerevisiae, is regulated by stress but is insensitive to the cAMP signalling pathway. Mol Genet Genomics. 2006;275:277-87 pubmed
  6. Takatsume Y, Ohdate T, Maeta K, Nomura W, Izawa S, Inoue Y. Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca(2+) in Saccharomyces cerevisiae. Biochem J. 2010;427:275-87 pubmed publisher
    ..following treatment with Ca2+ and is dependent on the MAPK (mitogen-activated protein kinase) Hog1 protein and the Msn2/Msn4 transcription factors...
  7. Boy Marcotte E, Perrot M, Bussereau F, Boucherie H, Jacquet M. Msn2p and Msn4p control a large number of genes induced at the diauxic transition which are repressed by cyclic AMP in Saccharomyces cerevisiae. J Bacteriol. 1998;180:1044-52 pubmed
    The multicopy suppressors of the snf1 defect, Msn2p and Msn4p transcription factors (Msn2/4p), activate genes through the stress-responsive cis element (CCCCT) in response to various stresses...
  8. Bandhakavi S, Xie H, O Callaghan B, Sakurai H, Kim D, Griffin T. Hsf1 activation inhibits rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis. PLoS ONE. 2008;3:e1598 pubmed publisher
    ..cells activated for Hsf1, constitutive activation of other regulators of heat/oxidative stress responses, such as Msn2/4 and Hyr1, did not inhibit TOR signaling...
  9. Smith A, Ward M, Garrett S. Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation. EMBO J. 1998;17:3556-64 pubmed
    ..These results suggest that Msn2p/Msn4p-dependent gene expression may account for all, or at least most, of the pleiotropic effects of yeast PKA, including growth regulation, response to stress and carbohydrate store accumulation. ..

More Information

Publications75

  1. Medvedik O, Lamming D, Kim K, Sinclair D. MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol. 2007;5:e261 pubmed
    ..These findings suggest that TOR and sirtuins may be part of the same longevity pathway in higher organisms, and that they may promote genomic stability during aging. ..
  2. Erkina T, Tschetter P, Erkine A. Different requirements of the SWI/SNF complex for robust nucleosome displacement at promoters of heat shock factor and Msn2- and Msn4-regulated heat shock genes. Mol Cell Biol. 2008;28:1207-17 pubmed
    The stress response in yeast cells is regulated by at least two classes of transcription activators-HSF and Msn2/4, which differentially affect promoter chromatin remodeling...
  3. Fabrizio P, Pozza F, Pletcher S, Gendron C, Longo V. Regulation of longevity and stress resistance by Sch9 in yeast. Science. 2001;292:288-90 pubmed
    ..Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 were required for this life-span extension...
  4. Ferguson S, Anderson E, Harshaw R, Thate T, Craig N, Nelson H. Protein kinase A regulates constitutive expression of small heat-shock genes in an Msn2/4p-independent and Hsf1p-dependent manner in Saccharomyces cerevisiae. Genetics. 2005;169:1203-14 pubmed
    ..activity strongly derepresses transcription of the small heat-shock genes HSP26 and HSP12, even in the absence of MSN2/4...
  5. Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, et al. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet. 2008;4:e13 pubmed publisher
    ..Deletion of stress resistance transcription factors Gis1 and Msn2/4, which are positively regulated by Rim15, also caused a major although not complete reversion of the effect of ..
  6. Schmitt A, McEntee K. Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1996;93:5777-82 pubmed
    ..gt11 library was screened to isolate clones encoding STRE-binding proteins, and one such gene was identified as MSN2, which encoded a zinc-finger transcriptional activator...
  7. Alejandro Osorio A, Huebert D, Porcaro D, Sonntag M, Nillasithanukroh S, Will J, et al. The histone deacetylase Rpd3p is required for transient changes in genomic expression in response to stress. Genome Biol. 2009;10:R57 pubmed publisher
    ..Our results implicate Rpd3p as an important co-factor in the Environmental Stress Response regulatory network, and suggest the importance of histone modification in producing transient changes in gene expression triggered by stress. ..
  8. Vendrell A, Martínez Pastor M, Gonzalez Novo A, Pascual Ahuir A, Sinclair D, Proft M, et al. Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase. EMBO Rep. 2011;12:1062-8 pubmed publisher
    ..Mutations of the SCF(CDC4) ubiquitin ligase complex suppress cell death by preventing the degradation of Msn2 and Msn4 transcription factors...
  9. Durchschlag E, Reiter W, Ammerer G, Schüller C. Nuclear localization destabilizes the stress-regulated transcription factor Msn2. J Biol Chem. 2004;279:55425-32 pubmed
    ..A large part of this response is mediated by the stress responsive transcription factor Msn2. During glucose exhaustion, Msn2 is activated and concentrated in the nucleus...
  10. Hasan R, Leroy C, Isnard A, Labarre J, Boy Marcotte E, Toledano M. The control of the yeast H2O2 response by the Msn2/4 transcription factors. Mol Microbiol. 2002;45:233-41 pubmed
    We have analysed the contribution of the Msn2/4 transcription factors and the Ras-cAMP-protein kinase A (PKA) pathway to the control of the yeast H2O2 response...
  11. Mayordomo I, Estruch F, Sanz P. Convergence of the target of rapamycin and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptional activator of STRE (Stress Response Element)-regulated genes. J Biol Chem. 2002;277:35650-6 pubmed
    The subcellular localization of Msn2, a transcriptional activator of STRE (stress response element)-regulated genes, is modulated by carbon source availability...
  12. Kaida D, Yashiroda H, Toh e A, Kikuchi Y. Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression. Genes Cells. 2002;7:543-52 pubmed
    In response to various stressful situations, including diauxic conditions, the Msn2 and Msn4 transcription factors induce STRE-mediated gene expression of many stress responsive genes in Saccharomyces cerevisiae...
  13. Chi Y, Huddleston M, Zhang X, Young R, Annan R, Carr S, et al. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes Dev. 2001;15:1078-92 pubmed
    ..The multistress response transcriptional regulator Msn2 is also a substrate for Srb10 and is hyperphosphorylated in an Srb10-dependent manner upon heat-stress-induced ..
  14. Moskvina E, Schuller C, Maurer C, Mager W, Ruis H. A search in the genome of Saccharomyces cerevisiae for genes regulated via stress response elements. Yeast. 1998;14:1041-50 pubmed
    ..Double mutants (msn2 msn4) deficient in these transcription factors have been shown to be hypersensitive to severe stress conditions...
  15. Jacquet M, Renault G, Lallet S, De Mey J, Goldbeter A. Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiae. J Cell Biol. 2003;161:497-505 pubmed
    b>Msn2 and Msn4 are two related transcriptional activators that mediate a general response to stress in yeast Saccharomyces cerevisiae by eliciting the expression of specific sets of genes...
  16. Martinez Pastor M, Marchler G, Schuller C, Marchler Bauer A, Ruis H, Estruch F. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE). EMBO J. 1996;15:2227-35 pubmed
    The MSN2 and MSN4 genes encode homologous and functionally redundant Cys2His2 zinc finger proteins...
  17. Hao N, Budnik B, Gunawardena J, O Shea E. Tunable signal processing through modular control of transcription factor translocation. Science. 2013;339:460-4 pubmed publisher
    ..The budding yeast general stress-responsive TF Msn2 acted as a tunable signal processor that could track, filter, or integrate signals in an input-dependent manner...
  18. Lee P, Cho B, Joo H, Hahn J. Yeast Yak1 kinase, a bridge between PKA and stress-responsive transcription factors, Hsf1 and Msn2/Msn4. Mol Microbiol. 2008;70:882-95 pubmed publisher
    Hsf1 and Msn2/Msn4 transcription factors in Saccharomyces cerevisiae play important roles in cellular homeostasis by activating gene expression in response to multiple stresses including heat shock, oxidative stress and nutrient ..
  19. Görner W, Durchschlag E, Martinez Pastor M, Estruch F, Ammerer G, Hamilton B, et al. Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev. 1998;12:586-97 pubmed
    ..We propose stress and cAMP-regulated intracellular localization of Msn2p to be a key step in STRE-dependent transcription and in the general stress response. ..
  20. Sadeh A, Movshovich N, Volokh M, Gheber L, Aharoni A. Fine-tuning of the Msn2/4-mediated yeast stress responses as revealed by systematic deletion of Msn2/4 partners. Mol Biol Cell. 2011;22:3127-38 pubmed publisher
    The Msn2 and Msn4 transcription factors play major roles in the yeast general stress response by mediating the transcription of hundreds of genes...
  21. Gonze D, Jacquet M, Goldbeter A. Stochastic modelling of nucleocytoplasmic oscillations of the transcription factor Msn2 in yeast. J R Soc Interface. 2008;5 Suppl 1:S95-109 pubmed publisher
    Stress induces oscillatory nucleocytoplasmic shuttling of the transcription factor Msn2 in yeast. The subcellular localization of Msn2 is controlled by the cAMP-dependent protein kinase, PKA...
  22. Estruch F, Carlson M. Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae. Mol Cell Biol. 1993;13:3872-81 pubmed
    The MSN2 gene was selected as a multicopy suppressor in a temperature-sensitive SNF1 protein kinase mutant of Saccharomyces cerevisiae...
  23. Causton H, Ren B, Koh S, Harbison C, Kanin E, Jennings E, et al. Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell. 2001;12:323-37 pubmed
    ..The results of expression analysis with MSN2/MSN4 mutants support the model that the Msn2/Msn4 activators induce the common response to environmental change...
  24. De Wever V, Reiter W, Ballarini A, Ammerer G, Brocard C. A dual role for PP1 in shaping the Msn2-dependent transcriptional response to glucose starvation. EMBO J. 2005;24:4115-23 pubmed
    ..The main transcriptional activator that orchestrates this response is Msn2, whose nuclear localization and DNA binding are negatively controlled by the cAMP-dependent protein kinase (PKA)...
  25. Hao N, O Shea E. Signal-dependent dynamics of transcription factor translocation controls gene expression. Nat Struct Mol Biol. 2011;19:31-9 pubmed publisher
    ..or frequency of nuclear translocation of the Saccharomyces cerevisiae general stress response transcription factor Msn2. Through artificial control of the dynamics of Msn2 translocation, we reveal how distinct dynamical schemes ..
  26. Kandror O, Bretschneider N, Kreydin E, Cavalieri D, Goldberg A. Yeast adapt to near-freezing temperatures by STRE/Msn2,4-dependent induction of trehalose synthesis and certain molecular chaperones. Mol Cell. 2004;13:771-81 pubmed
    ..Their expression requires Msn2,4 transcription factors but also involves marked mRNA stabilization...
  27. Welch A, Gibney P, Botstein D, Koshland D. TOR and RAS pathways regulate desiccation tolerance in Saccharomyces cerevisiae. Mol Biol Cell. 2013;24:115-28 pubmed publisher
    ..We suggest that reduction of a specific intermediate in 60S biogenesis, resulting from conditions such as heat shock and nutrient deprivation, increases desiccation tolerance. ..
  28. Gao L, Bretscher A. Analysis of unregulated formin activity reveals how yeast can balance F-actin assembly between different microfilament-based organizations. Mol Biol Cell. 2008;19:1474-84 pubmed publisher
    ..Thus, cells must have a way of ensuring a proper balance between actin assembly pathways. ..
  29. Ha C, Kim K, Chang Y, Kim B, Huh W. The ?-1,3-glucanosyltransferase Gas1 regulates Sir2-mediated rDNA stability in Saccharomyces cerevisiae. Nucleic Acids Res. 2014;42:8486-99 pubmed publisher
    ..Remarkably, the gas1? mutation induces nuclear localization of Msn2/4 and stimulates the expression of PNC1, a gene encoding a nicotinamidase that functions as a Sir2 activator...
  30. Parua P, Young E. Binding and transcriptional regulation by 14-3-3 (Bmh) proteins requires residues outside of the canonical motif. Eukaryot Cell. 2014;13:21-30 pubmed publisher
    ..Bmh binding to the Adr1 regulatory domain, and its failure to bind when mutations are present, explains at a molecular level the transcriptional phenotype of ADR1(c) mutants. ..
  31. Gauci V, Beckhouse A, Lyons V, Beh E, Rogers P, Dawes I, et al. Zinc starvation induces a stress response in Saccharomyces cerevisiae that is mediated by the Msn2p and Msn4p transcriptional activators. FEMS Yeast Res. 2009;9:1187-95 pubmed publisher
    ..This study discovered the Msn2p and Msn4p (Msn2/4p) transcriptional activator proteins to be an additional control mechanism inducing the stress response during ..
  32. Haitani Y, Takagi H. Rsp5 is required for the nuclear export of mRNA of HSF1 and MSN2/4 under stress conditions in Saccharomyces cerevisiae. Genes Cells. 2008;13:105-16 pubmed publisher
    ..of stress proteins, we analyzed the expression and localization of two major transcription factors, Hsf1 and Msn2/4, required for stress protein gene expression in S. cerevisiae...
  33. AkhavanAghdam Z, Sinha J, Tabbaa O, Hao N. Dynamic control of gene regulatory logic by seemingly redundant transcription factors. elife. 2016;5: pubmed publisher
    ..Using single-cell imaging and microfluidics, we study the yeast general stress response transcription factor Msn2 and its seemingly redundant homolog Msn4...
  34. Watanabe D, Wu H, Noguchi C, Zhou Y, Akao T, Shimoi H. Enhancement of the initial rate of ethanol fermentation due to dysfunction of yeast stress response components Msn2p and/or Msn4p. Appl Environ Microbiol. 2011;77:934-41 pubmed publisher
    ..defects of sake yeasts in environmental stress responses mediated by transcription factors Msn2p and/or Msn4p (Msn2/4p) and stress response elements (STRE)...
  35. Martínez Montañés F, Rienzo A, Poveda Huertes D, Pascual Ahuir A, Proft M. Activator and repressor functions of the Mot3 transcription factor in the osmostress response of Saccharomyces cerevisiae. Eukaryot Cell. 2013;12:636-47 pubmed publisher
    ..These Mot3-activated stress genes also depend on the general stress activators Msn2 and Msn4. We confirm that both Mot3 and Msn4 bind directly to some promoter regions of this gene group...
  36. Malcher M, Schladebeck S, Mösch H. The Yak1 protein kinase lies at the center of a regulatory cascade affecting adhesive growth and stress resistance in Saccharomyces cerevisiae. Genetics. 2011;187:717-30 pubmed publisher
    ..In summary, our data suggest that Yak1 is at the center of a regulatory cascade for adhesive growth and stress resistance, which is under dual control of Whi3 and the PKA subunit Tpk1. ..
  37. Zhang N, Quan Z, Rash B, Oliver S. Synergistic effects of TOR and proteasome pathways on the yeast transcriptome and cell growth. Open Biol. 2013;3:120137 pubmed publisher
    ..regulates both the Yak1 and Rim15 kinases to modulate starvation-specific gene expression mediated by the Msn2/4 and Gis1 transcription factors...
  38. Schade B, Jansen G, Whiteway M, Entian K, Thomas D. Cold adaptation in budding yeast. Mol Biol Cell. 2004;15:5492-502 pubmed
    ..This implies that the cold-specific early response is mediated by a different and as yet uncharacterized regulatory mechanism. ..
  39. Liang C, Wang L, Lo W. Dissociation of the H3K36 demethylase Rph1 from chromatin mediates derepression of environmental stress-response genes under genotoxic stress in Saccharomyces cerevisiae. Mol Biol Cell. 2013;24:3251-62 pubmed publisher
    ..Of interest, the master stress-activated regulator Msn2 also regulates a subset of Rph1-repressed genes under oxidative stress...
  40. Casado C, González A, Platara M, Ruiz A, Arino J. The role of the protein kinase A pathway in the response to alkaline pH stress in yeast. Biochem J. 2011;438:523-33 pubmed publisher
    ..Alkaline pH causes rapid nuclear localization of the PKA-regulated Msn2 transcription factor which, together with Msn4, mediates a general stress response by binding with STRE (stress ..
  41. Sadeh A, Baran D, Volokh M, Aharoni A. Conserved motifs in the Msn2-activating domain are important for Msn2-mediated yeast stress response. J Cell Sci. 2012;125:3333-42 pubmed publisher
    The Msn2 and Msn4 transcription factors play crucial roles in the yeast general stress response. Previous studies identified several large functional domains of Msn2, mainly through crude truncations...
  42. Mirisola M, Taormina G, Fabrizio P, Wei M, Hu J, Longo V. Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging. PLoS Genet. 2014;10:e1004113 pubmed publisher
    ..Because of the conserved pro-aging role of nutrient and growth signaling pathways in higher eukaryotes, these results raise the possibility that similar mechanisms contribute to aging in mammals...
  43. Stewart Ornstein J, Nelson C, DeRisi J, Weissman J, El Samad H. Msn2 coordinates a stoichiometric gene expression program. Curr Biol. 2013;23:2336-45 pubmed publisher
    ..In this work, we document a relationship between stress-responsive gene expression and the transcription factor Msn2 that is graded over a large range of Msn2 concentrations...
  44. Reiter W, Klopf E, De Wever V, Anrather D, Petryshyn A, Roetzer A, et al. Yeast protein phosphatase 2A-Cdc55 regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 chromatin recruitment. Mol Cell Biol. 2013;33:1057-72 pubmed publisher
    ..is required for full activation of the environmental stress response mediated by the transcription factors Msn2 and Msn4...
  45. Izawa S, Ikeda K, Ohdate T, Inoue Y. Msn2p/Msn4p-activation is essential for the recovery from freezing stress in yeast. Biochem Biophys Res Commun. 2007;352:750-5 pubmed
    ..Since almost no expression of Msn2p/Msn4p-target genes was induced before thawing, these results indicate that Msn2p and Msn4p play a role during the recovery process from freezing. ..
  46. Yadav K, Singh N, Rajvanshi P, Rajasekharan R. The RNA polymerase I subunit Rpa12p interacts with the stress-responsive transcription factor Msn4p to regulate lipid metabolism in budding yeast. FEBS Lett. 2016;590:3559-3573 pubmed publisher
    ..Our findings reveal that Rpa12p functions as a negative regulator of lipid metabolism by modulating nonpolar lipid biosynthesis through its interaction with Msn4p. ..
  47. Tadi D, Hasan R, Bussereau F, Boy Marcotte E, Jacquet M. Selection of genes repressed by cAMP that are induced by nutritional limitation in Saccharomyces cerevisiae. Yeast. 1999;15:1733-45 pubmed
    ..The induction of 10 of these genes is reduced in the msn2,msn4 double mutant, which emphasizes the role of the Msn2/4p transcriptional activators in mediating the Ras-cAMP-..
  48. Erkina T, Lavrova M, Erkin A. [Alternative ways of stress regulation in cells of Saccharomyces cerevisiae: transcriptional activators Msn2 and Msn4]. Tsitologiia. 2009;51:271-8 pubmed
    ..cerevisiae this gene activation is determined by the action of two types of activators--HSF and partially redundant Msn2 and Msn4...
  49. Ruiz Roig C, Viéitez C, Posas F, de Nadal E. The Rpd3L HDAC complex is essential for the heat stress response in yeast. Mol Microbiol. 2010;76:1049-62 pubmed publisher
    ..Global gene expression analysis showed that Rpd3 partially regulated gene expression upon heat shock. The Hsf1 and Msn2/4 transcription factors are the main regulators of gene activation in response to heat stress...
  50. Reddi A, Culotta V. Regulation of manganese antioxidants by nutrient sensing pathways in Saccharomyces cerevisiae. Genetics. 2011;189:1261-70 pubmed publisher
    ..Downstream of Rim15p are transcription factors Gis1p and the redundant Msn2/Msn4p pair that typically respond to nutrient and stress signals...
  51. Gatti X, de Bettignies G, Claret S, Doignon F, Crouzet M, Thoraval D. RGD1, encoding a RhoGAP involved in low-pH survival, is an Msn2p/Msn4p regulated gene in Saccharomyces cerevisiae. Gene. 2005;351:159-69 pubmed
    ..The general stress-activated transcription factors Msn2p and Msn4p as well as the HOG pathway were shown to mainly act on the basal RGD1 transcriptional level in normal and stress conditions. ..
  52. Lenssen E, James N, Pedruzzi I, Dubouloz F, Cameroni E, Bisig R, et al. The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution. Mol Cell Biol. 2005;25:488-98 pubmed
    ..of this complex in yeast are TFIID, a general transcription factor that associates with the core promoter, and Msn2, a key transcription factor that regulates expression of stress-responsive element (STRE)-controlled genes...
  53. Horan S, Bourges I, Meunier B. Transcriptional response to nitrosative stress in Saccharomyces cerevisiae. Yeast. 2006;23:519-35 pubmed
    ..We showed also that Msn2/4p and Yap1p, key regulators of the response to general stress and oxidative stress, respectively, played a role in ..
  54. Rajvanshi P, Arya M, Rajasekharan R. The stress-regulatory transcription factors Msn2 and Msn4 regulate fatty acid oxidation in budding yeast. J Biol Chem. 2017;292:18628-18643 pubmed publisher
    The transcription factors Msn2 and Msn4 (multicopy suppressor of SNF1 mutation proteins 2 and 4) bind the stress-response element in gene promoters in the yeast Saccharomyces cerevisiae However, the roles of Msn2/4 in ..
  55. Li L, Kaplan J, Ward D. The glucose sensor Snf1 and the transcription factors Msn2 and Msn4 regulate transcription of the vacuolar iron importer gene CCC1 and iron resistance in yeast. J Biol Chem. 2017;292:15577-15586 pubmed publisher
    ..The Snf1 complex is known to activate the general stress transcription factors Msn2 and Msn4. We show that Msn2 and Msn4 contribute to Snf1-mediated CCC1 transcription...
  56. Inoue Y, Tsujimoto Y, Kimura A. Expression of the glyoxalase I gene of Saccharomyces cerevisiae is regulated by high osmolarity glycerol mitogen-activated protein kinase pathway in osmotic stress response. J Biol Chem. 1998;273:2977-83 pubmed
    ..A double mutant of the MSN2 and MSN4 gene was unable to induce expression of the GLO1 gene under highly osmotic conditions...
  57. Hirata Y, Andoh T, Asahara T, Kikuchi A. Yeast glycogen synthase kinase-3 activates Msn2p-dependent transcription of stress responsive genes. Mol Biol Cell. 2003;14:302-12 pubmed
    ..whose promoter regions possess STRE sequences, on induction by heat shock or salt stress was reduced not only in an msn2 msn4 (msn2 homologue) double mutant but also in the gsk-3 null mutant...
  58. Lai L, Kosorukoff A, Burke P, Kwast K. Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media. Mol Cell Biol. 2005;25:4075-91 pubmed
    ..in both catabolite-repressed (glucose) and derepressed (galactose) cells, assessed the specific role that Msn2 and Msn4 play in mediating the response, and identified gene networks using a novel clustering approach...
  59. Shenhar G, Kassir Y. A positive regulator of mitosis, Sok2, functions as a negative regulator of meiosis in Saccharomyces cerevisiae. Mol Cell Biol. 2001;21:1603-12 pubmed
    ..IREu, a 32-bp element in the IME1 promoter, exhibits upstream activation sequence activity depending on Msn2 and -4 and the presence of acetate...
  60. Domitrovic T, Fernandes C, Boy Marcotte E, Kurtenbach E. High hydrostatic pressure activates gene expression through Msn2/4 stress transcription factors which are involved in the acquired tolerance by mild pressure precondition in Saccharomyces cerevisiae. FEBS Lett. 2006;580:6033-8 pubmed
    b>Msn2 and Msn4 transcription factors activate expression of stress-responsive element (STRE) controlled genes in response to various stresses triggering the environmental stress response in Saccharomyces cerevisiae...
  61. Hansen A, O Shea E. Limits on information transduction through amplitude and frequency regulation of transcription factor activity. elife. 2015;4: pubmed publisher
    ..information transduction, we apply information theory to quantify how much gene expression information the yeast TF Msn2 can transduce to target genes in the amplitude or frequency of its activation dynamics...
  62. Quan Z, Cao L, Tang Y, Yan Y, Oliver S, Zhang N. The Yeast GSK-3 Homologue Mck1 Is a Key Controller of Quiescence Entry and Chronological Lifespan. PLoS Genet. 2015;11:e1005282 pubmed publisher
    ..One involves the negative regulation of the effectors of G0 entry such as Mck1 and Rim15, while the other likely to involve its functions in promoting respiratory growth, a phenotype also contributed by Mck1 and Rim15. ..
  63. Umekawa M, Ujihara M, Makishima K, Yamamoto S, Takematsu H, Wakayama M. The signaling pathways underlying starvation-induced upregulation of α-mannosidase Ams1 in Saccharomyces cerevisiae. Biochim Biophys Acta. 2016;1860:1192-201 pubmed publisher
    ..Our data showed that the activity of Ams1 is regulated by the stress responsive transcriptional factors Msn2/4 through the protein kinase A and the target of rapamycin complex 1 pathways...
  64. Schüller C, Mamnun Y, Mollapour M, Krapf G, Schuster M, Bauer B, et al. Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae. Mol Biol Cell. 2004;15:706-20 pubmed
    ..Our results suggest that combining functional assays with transcriptome profiling allows for the identification of key components in large datasets such as those generated by global microarray analysis...
  65. Bodvard K, Jörhov A, Blomberg A, Molin M, Käll M. The yeast transcription factor Crz1 is activated by light in a Ca2+/calcineurin-dependent and PKA-independent manner. PLoS ONE. 2013;8:e53404 pubmed publisher
    ..by increased protein kinase A activity (PKA), which strongly inhibits light-induced nuclear localization of Msn2/4p...
  66. Li S, Diakov T, Rizzo J, Kane P. Vacuolar H+-ATPase works in parallel with the HOG pathway to adapt Saccharomyces cerevisiae cells to osmotic stress. Eukaryot Cell. 2012;11:282-91 pubmed publisher
    ..Together, these data suggest that the V-ATPase acts in parallel with the HOG pathway in order to mediate salt detoxification. ..