Gene Symbol: MRS6
Description: GTPase-activating protein MRS6
Alias: MSI4, GTPase-activating protein MRS6
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Fujimura K, Tanaka K, Nakano A, Toh e A. The Saccharomyces cerevisiae MSI4 gene encodes the yeast counterpart of component A of Rab geranylgeranyltransferase. J Biol Chem. 1994;269:9205-12 pubmed
    We describe the isolation of MSI4 as a multicopy suppressor of ira1 (inhibitory regulator of Ras)...
  2. Jiang Y, Ferro Novick S. Identification of yeast component A: reconstitution of the geranylgeranyltransferase that modifies Ypt1p and Sec4p. Proc Natl Acad Sci U S A. 1994;91:4377-81 pubmed
    ..The yeast MRS6 gene encodes a protein that is approximately 30% identical to the choroideremia gene product...
  3. Benito Moreno R, Miaczynska M, Bauer B, Schweyen R, Ragnini A. Mrs6p, the yeast homologue of the mammalian choroideraemia protein: immunological evidence for its function as the Ypt1p Rab escort protein. Curr Genet. 1994;27:23-5 pubmed
    The Saccharomyces cerevisiae MRS6 gene belongs to the same gene family as that responsible for the mammalian Rab escort protein (REP) and the Rab GDP dissociation inhibitor protein (GDI)...
  4. Bialek Wyrzykowska U, Bauer B, Wagner W, Kohlwein S, Schweyen R, Ragnini A. Low levels of Ypt protein prenylation cause vesicle polarization defects and thermosensitive growth that can be suppressed by genes involved in cell wall maintenance. Mol Microbiol. 2000;35:1295-311 pubmed
    ..Here, we report the characterization of a yeast REP mutant, mrs6-2, in which reduced prenylation of Ypt proteins occurs even at the permissive temperature...
  5. Jiang Y, Rossi G, Ferro Novick S. Characterization of yeast type-II geranylgeranyltransferase. Methods Enzymol. 1995;257:21-9 pubmed
  6. Bauer B, Lorenzetti S, Miaczynska M, Bui D, Schweyen R, Ragnini A. Amino- and carboxy-terminal domains of the yeast Rab escort protein are both required for binding of Ypt small G proteins. Mol Biol Cell. 1996;7:1521-33 pubmed
    ..The only known yeast homologue of the choroideremia gene product is encoded by an essential gene called MRS6. Besides three structurally conserved regions (SCRs) previously detected in the amino-terminal half of REPs and ..
  7. Alory C, Balch W. Molecular basis for Rab prenylation. J Cell Biol. 2000;150:89-103 pubmed complement growth of a mrs6Delta null strain and were found to be dominant inhibitors of growth in a wild-type MRS6 strain...
  8. Ignatev A, Kravchenko S, Rak A, Goody R, Pylypenko O. A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism. J Biol Chem. 2008;283:18377-84 pubmed publisher
    ..The investigated thermodynamic properties of yeast Rab.GDI and Rab.MRS6 complexes demonstrated differences in the Rab binding properties of the closely related Rab GDI and MRS6 proteins, ..
  9. LempiƤinen H, Uotila A, Urban J, Dohnal I, Ammerer G, Loewith R, et al. Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling. Mol Cell. 2009;33:704-16 pubmed publisher
    ..Finally, we show that the Sfp1-interacting protein Mrs6, a Rab escort protein involved in membrane trafficking, regulates both Sfp1 nuclear localization and TORC1 ..

More Information


  1. Singh J, Tyers M. A Rab escort protein integrates the secretion system with TOR signaling and ribosome biogenesis. Genes Dev. 2009;23:1944-58 pubmed publisher
    ..Notably, the essential Rab escort protein Mrs6 exhibited a nutrient-sensitive interaction with Sfp1...
  2. Ragnini A, Teply R, Waldherr M, Voskova A, Schweyen R. The yeast protein Mrs6p, a homologue of the rabGDI and human choroideraemia proteins, affects cytoplasmic and mitochondrial functions. Curr Genet. 1994;26:308-14 pubmed
    b>MRS6 is a newly-identified gene in the yeast Saccharomyces cerevisiae...
  3. Miaczynska M, Lorenzetti S, Bialek U, Benito Moreno R, Schweyen R, Ragnini A. The yeast Rab escort protein binds intracellular membranes in vivo and in vitro. J Biol Chem. 1997;272:16972-7 pubmed
    ..Although prenylation is believed to take place in the cytosol, we show that the yeast Rab escort protein Mrs6 is present in both soluble and particulate fractions of cell extracts...
  4. Dursina B, Thoma N, Sidorovitch V, Niculae A, Iakovenko A, Rak A, et al. Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates. Biochemistry. 2002;41:6805-16 pubmed
    ..Despite the ability to function in concert with yRabGGTase in vitro, expression of mammalian REP-1 could not complement deletion of MRS6 gene in S. cerevisiae in vivo. The implications of these findings are discussed.
  5. Alory C, Balch W. Molecular evolution of the Rab-escort-protein/guanine-nucleotide-dissociation-inhibitor superfamily. Mol Biol Cell. 2003;14:3857-67 pubmed
    ..We have now isolated REP mutant proteins that are able to partially function as both REP and GDI. These results provide molecular insight into the functional and evolutionary organization of the REP/GDI superfamily. ..
  6. Lo S, Brett C, Plemel R, Vignali M, Fields S, Gonen T, et al. Intrinsic tethering activity of endosomal Rab proteins. Nat Struct Mol Biol. 2011;19:40-7 pubmed publisher
    ..In our working model, the intrinsic tethering capacity Vps21 operates in concert with conventional effectors and SNAREs to drive efficient docking and fusion. ..