MRS2

Summary

Gene Symbol: MRS2
Description: Mrs2p
Alias: Mrs2p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Ragnini A, Teply R, Waldherr M, Voskova A, Schweyen R. The yeast protein Mrs6p, a homologue of the rabGDI and human choroideraemia proteins, affects cytoplasmic and mitochondrial functions. Curr Genet. 1994;26:308-14 pubmed
    ..mitochondrial functions as revealed by the facts that high-copy numbers of MRS6 (1) suppress the pet- phenotype of mrs2-1 mutant strains and (2) cause a weak pet- phenotype in wild-type strains...
  2. Waldherr M, Ragnini A, Jank B, Teply R, Wiesenberger G, Schweyen R. A multitude of suppressors of group II intron-splicing defects in yeast. Curr Genet. 1993;24:301-6 pubmed
    Disruption of the nuclear MRS2 gene (mrs2-1 mutation) causes a strong pet- phenotype in strains with mitochondrial group II introns, and a leaky pet- phenotype in strains without group II introns...
  3. Jarosch E, Tuller G, Daum G, Waldherr M, Voskova A, Schweyen R. Mrs5p, an essential protein of the mitochondrial intermembrane space, affects protein import into yeast mitochondria. J Biol Chem. 1996;271:17219-25 pubmed
    We have isolated a yeast nuclear gene that suppresses the previously described respiration-deficient mrs2-1 mutation when present on a multicopy plasmid...
  4. Gregan J, Kolisek M, Schweyen R. Mitochondrial Mg(2+) homeostasis is critical for group II intron splicing in vivo. Genes Dev. 2001;15:2229-37 pubmed
    The product of the nuclear MRS2 gene, Mrs2p, is the only candidate splicing factor essential for all group II introns in mitochondria of the yeast Saccharomyces cerevisiae...
  5. Kolisek M, Zsurka G, Samaj J, Weghuber J, Schweyen R, Schweigel M. Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria. EMBO J. 2003;22:1235-44 pubmed
    Steady-state concentrations of mitochondrial Mg(2+) previously have been shown to vary with the expression of Mrs2p, a component of the inner mitochondrial membrane with two transmembrane domains...
  6. Sponder G, Svidova S, Schindl R, Wieser S, Schweyen R, Romanin C, et al. Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel. FEBS J. 2010;277:3514-25 pubmed publisher
    Saccharomyces cerevisiae Lpe10p is a homologue of the Mg(2+)-channel-forming protein Mrs2p in the inner mitochondrial membrane...
  7. Vallieres C, Trouillard M, Dujardin G, Meunier B. Deleterious effect of the Qo inhibitor compound resistance-conferring mutation G143A in the intron-containing cytochrome b gene and mechanisms for bypassing it. Appl Environ Microbiol. 2011;77:2088-93 pubmed publisher
    ..We also found that overexpression of nuclear genes MRS2 and MRS3, encoding mitochondrial metal ion carriers, partially restores the respiratory growth of the G143A mutant...
  8. Bui D, Gregan J, Jarosch E, Ragnini A, Schweyen R. The bacterial magnesium transporter CorA can functionally substitute for its putative homologue Mrs2p in the yeast inner mitochondrial membrane. J Biol Chem. 1999;274:20438-43 pubmed
    ..Here we show that the MRS2 gene product (Mrs2p) is an integral protein of the inner mitochondrial membrane...
  9. Weghuber J, Dieterich F, Froschauer E, Svidova S, Schweyen R. Mutational analysis of functional domains in Mrs2p, the mitochondrial Mg2+ channel protein of Saccharomyces cerevisiae. FEBS J. 2006;273:1198-209 pubmed
    The nuclear gene MRS2 in Saccharomyces cerevisiae encodes an integral protein (Mrs2p) of the inner mitochondrial membrane. It forms an ion channel mediating influx of Mg2+ into mitochondria...

More Information

Publications13

  1. Khan M, Sjöblom B, Schweyen R, Djinovic Carugo K. Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of Mrs2, a magnesium ion transporter from yeast inner mitochondrial membrane. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:658-61 pubmed publisher
    b>Mrs2 transporters are distantly related to the major bacterial Mg(2+) transporter CorA and to Alr1, which is found in the plasma membranes of lower eukaryotes...
  2. Khan M, Sponder G, Sjöblom B, Svidova S, Schweyen R, Carugo O, et al. Structural and functional characterization of the N-terminal domain of the yeast Mg2+ channel Mrs2. Acta Crystallogr D Biol Crystallogr. 2013;69:1653-64 pubmed publisher
    Mg(2+) translocation across cellular membranes is crucial for a myriad of physiological processes. Eukaryotic Mrs2 transporters are distantly related to the major bacterial Mg(2+) transporter CorA, the structure of which displays a bundle ..
  3. Cui Y, Zhao S, Wang J, Wang X, Gao B, Fan Q, et al. A novel mitochondrial carrier protein Mme1 acts as a yeast mitochondrial magnesium exporter. Biochim Biophys Acta. 2015;1853:724-32 pubmed publisher
    ..Previously, two mitochondrial Mg2+ importers, Mrs2 and Lpe10, were characterized for mitochondrial Mg2+ uptake...
  4. Van Dyck E, Jank B, Ragnini A, Schweyen R, Duyckaerts C, Sluse F, et al. Overexpression of a novel member of the mitochondrial carrier family rescues defects in both DNA and RNA metabolism in yeast mitochondria. Mol Gen Genet. 1995;246:426-36 pubmed
    The PIF1 and MRS2 gene products have previously been shown to be essential for mitochondrial DNA maintenance at elevated temperatures and mitochondrial group II intron splicing, respectively, in the yeast Saccharomyces cerevisiae...