Gene Symbol: MRPL4
Description: mitochondrial 54S ribosomal protein YmL4
Alias: mitochondrial 54S ribosomal protein YmL4
Species: Saccharomyces cerevisiae S288c
Gruschke S, Gröne K, Heublein M, Hölz S, Israel L, Imhof A, et al
. Proteins at the polypeptide tunnel exit of the yeast mitochondrial ribosome. J Biol Chem. 2010;285:19022-8 pubmed publisher
..This unique architecture of the tunnel exit is presumably an adaptation of the translation system to the specific requirements of the organelle. ..
Graack H, Grohmann L, Choli T. Mitochondrial ribosomes of yeast: isolation of individual proteins and N-terminal sequencing. FEBS Lett. 1988;242:4-8 pubmed
..No significant homology to ribosomal protein sequences so far determined from other organisms was found. ..
Markov D, Savkina M, Anikin M, Del Campo M, Ecker K, Lambowitz A, et al
. Identification of proteins associated with the yeast mitochondrial RNA polymerase by tandem affinity purification. Yeast. 2009;26:423-40 pubmed publisher
..Further, we found that Mss116p inhibits transcription by mtRNAP in vitro in a steady-state reaction. Our results support the hypothesis that Mss116p and Pet127p are involved in modulation of mtRNAP activity. ..
Graack H, Grohmann L, Kitakawa M, Goldschmidt Reisin S. Gene MRP-L4, encoding mitochondrial ribosomal protein YmL4, is indispensable for proper non-respiratory cell functions in yeast. Gene. 1995;152:107-12 pubmed
Paul M, Alushin G, Barros M, Rak M, Tzagoloff A. The putative GTPase encoded by MTG3 functions in a novel pathway for regulating assembly of the small subunit of yeast mitochondrial ribosomes. J Biol Chem. 2012;287:24346-55 pubmed publisher
..The rescue is accompanied by an increase in processed 15 S rRNA. This suggests that Mtg3p and Mrpl4p jointly regulate assembly of the small subunit by modulating processing of the 15 S rRNA precursor. ..
Gruschke S, Kehrein K, Römpler K, Gröne K, Israel L, Imhof A, et al
. Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. J Cell Biol. 2011;193:1101-14 pubmed publisher
Kaur J, Stuart R. Truncation of the Mrp20 protein reveals new ribosome-assembly subcomplex in mitochondria. EMBO Rep. 2011;12:950-5 pubmed publisher
..Finally, data supporting the idea that the inner mitochondrial membrane acts as a platform for the ribosome assembly process are discussed. ..