MNN9

Summary

Gene Symbol: MNN9
Description: mannosyltransferase complex subunit MNN9
Alias: mannosyltransferase complex subunit MNN9
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Rodionov D, Romero P, Berghuis A, Herscovics A. Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity. Protein Expr Purif. 2009;66:1-6 pubmed publisher
    ..No alpha-1,2 mannosyltransferase activity, reported previously for M-Pol I immunoprecipitates from cell extracts was detected. These results provide further information on the role of M-Pol I in mannan biosynthesis. ..
  2. Noda Y, Yoda K. Svp26 facilitates endoplasmic reticulum to golgi transport of a set of mannosyltransferases in Saccharomyces cerevisiae. J Biol Chem. 2010;285:15420-9 pubmed publisher
    ..The domain switching between Svp26-dependent Mnn2 or Ktr3 and Svp26-independent Mnn1 suggests that the lumenal domain of mannosyltransferases, but not the cytoplasmic or transmembrane domain, is responsible for recognition by Svp26. ..
  3. Jungmann J, Munro S. Multi-protein complexes in the cis Golgi of Saccharomyces cerevisiae with alpha-1,6-mannosyltransferase activity. EMBO J. 1998;17:423-34 pubmed
    ..Our data suggest that these two multi-protein complexes are responsible for the synthesis and initial branching of the long alpha-1,6-linked backbone of the hypermannose structure attached to many yeast glycoproteins. ..
  4. Rayner J, Munro S. Identification of the MNN2 and MNN5 mannosyltransferases required for forming and extending the mannose branches of the outer chain mannans of Saccharomyces cerevisiae. J Biol Chem. 1998;273:26836-43 pubmed
    ..The identification of Mnn2p and Mnn5p allows us to assign Golgi proteins to all of the catalytic steps in S. cerevisiae mannan synthesis. ..
  5. Jungmann J, Rayner J, Munro S. The Saccharomyces cerevisiae protein Mnn10p/Bed1p is a subunit of a Golgi mannosyltransferase complex. J Biol Chem. 1999;274:6579-85 pubmed
  6. Kojima H, Hashimoto H, Yoda K. Interaction among the subunits of Golgi membrane mannosyltransferase complexes of the yeast Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 1999;63:1970-6 pubmed
    Saccharomyces cerevisiae Mnn9 protein is a type II Golgi membrane protein which concerns in protein mannosylation...
  7. Hashimoto H, Yoda K. Novel membrane protein complexes for protein glycosylation in the yeast Golgi apparatus. Biochem Biophys Res Commun. 1997;241:682-6 pubmed
    Three type II membrane proteins Anp1, Van1 and Mnn9 of Saccharomyces cerevisiae share significant sequence homology...
  8. Cho J, Noda Y, Yoda K. Proteins in the early golgi compartment of Saccharomyces cerevisiae immunoisolated by Sed5p. FEBS Lett. 2000;469:151-4 pubmed
  9. Todorow Z, Spang A, Carmack E, Yates J, Schekman R. Active recycling of yeast Golgi mannosyltransferase complexes through the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2000;97:13643-8 pubmed
    ..These observations indicate that the Mnn9p-containing mannosyltransferase complexes cycle back and forth between the ER and Golgi. ..

More Information

Publications16

  1. Schmidt M, Strenk M, Boyer M, Fritsch B. Importance of cell wall mannoproteins for septum formation in Saccharomyces cerevisiae. Yeast. 2005;22:715-23 pubmed
    The mannosyltransferase mutants mnn9 and mnn10 were isolated in a genetic screen for septation defects in Saccharomyces cerevisiae...
  2. Striebeck A, Robinson D, Schüttelkopf A, van Aalten D. Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis. Open Biol. 2013;3:130022 pubmed publisher
    ..Saccharomyces cerevisiae and Candida albicans mnn9 knockouts show an aberrant cell wall and increased antibiotic sensitivity, suggesting the enzyme is a potential ..
  3. Osmond B, Specht C, Robbins P. Chitin synthase III: synthetic lethal mutants and "stress related" chitin synthesis that bypasses the CSD3/CHS6 localization pathway. Proc Natl Acad Sci U S A. 1999;96:11206-10 pubmed
    ..wall-related genes such as FKS1 (glucan synthase) and mutations in any of the Golgi glycosylation complex genes (MNN9 family) are lethal in combination with chs3Delta, we found that a mutation in Srv2p, a bifunctional regulatory gene,..
  4. Horie T, Isono K. Cooperative functions of the mannoprotein-encoding genes in the biogenesis and maintenance of the cell wall in Saccharomyces cerevisiae. Yeast. 2001;18:1493-503 pubmed
    ..Thus, double mutants of SED1 and either MNN9 or MNN10 were unable to grow and YOL155c on a multicopy plasmid could suppress their synthetic lethality...
  5. Kurischko C, Kuravi V, Wannissorn N, Nazarov P, Husain M, Zhang C, et al. The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. Mol Biol Cell. 2008;19:5559-78 pubmed publisher
    ..These data suggest that an important function for Cbk1 and the RAM signaling network is to regulate growth and secretion via Golgi and Sec2/Sec4-dependent processes. ..
  6. Curwin A, LeBlanc M, Fairn G, McMaster C. Localization of lipid raft proteins to the plasma membrane is a major function of the phospholipid transfer protein Sec14. PLoS ONE. 2013;8:e55388 pubmed publisher
    ..Localization of both lipid raft proteins was restored upon increased expression of the sec14(ts) allele. We suggest that a major function provided by Sec14 is trafficking and localization of lipid raft proteins. ..
  7. Morimoto Y, Tani M. Synthesis of mannosylinositol phosphorylceramides is involved in maintenance of cell integrity of yeast Saccharomyces cerevisiae. Mol Microbiol. 2015;95:706-22 pubmed publisher
    ..These results indicated that loss of MIPC synthesis causes impairment of cell integrity, and this effect is enhanced by impaired synthesis of mannan-type N-glycans. ..