MMT1

Summary

Gene Symbol: MMT1
Description: Mmt1p
Alias: MFT1, Mmt1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Li L, Kaplan J. Characterization of two homologous yeast genes that encode mitochondrial iron transporters. J Biol Chem. 1997;272:28485-93 pubmed
    ..Measurement of mitochondrial iron in cells grown in iron-rich medium overexpressing MFT1 or MFT2 show a 2-5-fold increase in iron compared with mitochondria from control cells...
  2. Jensen L, Sanchez R, Srinivasan C, Valentine J, Culotta V. Mutations in Saccharomyces cerevisiae iron-sulfur cluster assembly genes and oxidative stress relevant to Cu,Zn superoxide dismutase. J Biol Chem. 2004;279:29938-43 pubmed
    ..By contrast, increasing the mitochondrial iron content of sod1Delta yeast using high copy MMT1, which encodes a mitochondrial iron transporter, was sufficient to mimic the seo mutants...
  3. Li L, Miao R, Jia X, Ward D, Kaplan J. Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export. J Biol Chem. 2014;289:17132-41 pubmed publisher
    b>Mmt1 and Mmt2 are highly homologous yeast members of the cation diffusion facilitator transporter family localized to mitochondria...