Gene Symbol: MMM1
Description: ERMES complex subunit MMM1
Alias: YME6, ERMES complex subunit MMM1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Yamano K, Tanaka Yamano S, Endo T. Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40. EMBO Rep. 2010;11:187-93 pubmed publisher
    ..Mdm10 is distributed in the TOB complex for beta-barrel protein assembly and in the MMM1 complex for tethering of the endoplasmic reticulum and mitochondria...
  2. Hanekamp T, Thorsness M, Rebbapragada I, Fisher E, Seebart C, Darland M, et al. Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Saccharomyces cerevisiae. Genetics. 2002;162:1147-56 pubmed
    In the yeast Saccharomyces cerevisiae, certain mutant alleles of YME4, YME6, and MDM10 cause an increased rate of mitochondrial DNA migration to the nucleus, carbon-source-dependent alterations in mitochondrial morphology, and increased ..
  3. Boldogh I, Nowakowski D, Yang H, Chung H, Karmon S, Royes P, et al. A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery. Mol Biol Cell. 2003;14:4618-27 pubmed
    ..Moreover, Mdm10p localized to mitochondria in the absence of the other subunits. In contrast, deletion of MMM1 resulted in mislocalization of Mdm12p, and deletion of MDM12 caused mislocalization of Mmm1p...
  4. Meisinger C, Pfannschmidt S, Rissler M, Milenkovic D, Becker T, Stojanovski D, et al. The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J. 2007;26:2229-39 pubmed
    ..Mdm12/Mmm1 function after SAM(core) yet before splitting of the major pathway...
  5. Kornmann B, Currie E, Collins S, Schuldiner M, Nunnari J, Weissman J, et al. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science. 2009;325:477-81 pubmed publisher
    ..We identified the Mmm1/Mdm10/Mdm12/Mdm34 complex as a molecular tether between ER and mitochondria...
  6. Berger K, Yaffe M. Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol. 1998;18:4043-52 pubmed
    ..These results provide the first evidence of a role for prohibitin in mitochondrial inheritance and in the regulation of mitochondrial morphology. ..
  7. Stroud D, Oeljeklaus S, Wiese S, Bohnert M, Lewandrowski U, Sickmann A, et al. Composition and topology of the endoplasmic reticulum-mitochondria encounter structure. J Mol Biol. 2011;413:743-50 pubmed publisher
    ..Four ERMES proteins are known in yeast, the ER-anchored protein Mmm1 and three mitochondria-associated proteins, Mdm10, Mdm12 and Mdm34, with functions related to mitochondrial ..
  8. Meeusen S, Nunnari J. Evidence for a two membrane-spanning autonomous mitochondrial DNA replisome. J Cell Biol. 2003;163:503-10 pubmed
    ..Taken together, our observations reveal the existence of an autonomous two membrane-spanning mitochondrial replisome as well as provide a mechanism for how mtDNA replication and inheritance may be physically linked. ..
  9. Hobbs A, Srinivasan M, McCaffery J, Jensen R. Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability. J Cell Biol. 2001;152:401-10 pubmed
    ..Mmm1p is required to maintain normal mitochondrial shape and in mmm1 mutants mitochondria form large, spherical organelles...

More Information


  1. Burgess S, Delannoy M, Jensen R. MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. J Cell Biol. 1994;126:1375-91 pubmed
    ..One of these mutants, mmm1, is temperature-sensitive for the external shape of its mitochondria...
  2. Yamano K, Tanaka Yamano S, Endo T. Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40. J Biol Chem. 2010;285:41222-31 pubmed publisher
    ..These results collectively show that Tom7 recruits Mdm10, enhancing its association with the MMM1 complex, to regulate timing of the release of Tom40 from the TOB complex for subsequent assembly into the TOM40 ..
  3. Tan T, Ozbalci C, Br gger B, Rapaport D, Dimmer K. Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis. J Cell Sci. 2013;126:3563-74 pubmed publisher
    ..Collectively, this work identifies two novel proteins that play a role in mitochondrial lipid homeostasis and describes a role of Mdm10 in ergosterol trafficking...
  4. Tamura Y, Onguka O, Hobbs A, Jensen R, Iijima M, Claypool S, et al. Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking. J Biol Chem. 2012;287:15205-18 pubmed publisher
    ..Our results suggest that Ups proteins and Mdm31p play important roles in phospholipid biosynthesis in mitochondria. Ups proteins may function in phospholipid trafficking between the outer and inner mitochondrial membranes. ..
  5. Lang A, John Peter A, Walter P, Kornmann B. ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13. J Cell Biol. 2015;210:883-90 pubmed publisher
  6. Park J, Thorsness M, Policastro R, McGoldrick L, Hollingsworth N, Thorsness P, et al. Yeast Vps13 promotes mitochondrial function and is localized at membrane contact sites. Mol Biol Cell. 2016;27:2435-49 pubmed publisher
    ..Introduction of VPS13A mutations identified in ChAc patients at cognate sites in yeast VPS13 are specifically defective in compensating for the lack of ERMES, suggesting that mitochondrial dysfunction might be the basis for ChAc. ..
  7. Kojima R, Kajiura S, Sesaki H, Endo T, Tamura Y. Identification of multi-copy suppressors for endoplasmic reticulum-mitochondria tethering proteins in Saccharomyces cerevisiae. FEBS Lett. 2016;590:3061-70 pubmed publisher
    ..To gain insight into ERMES functions, we screened multi-copy suppressors of the growth-defective phenotype of mmm1? cells, which lack a core component of ERMES, and identified MCP1, MGA2, SPT23, and YGR250C (termed RIE1)...
  8. Nguyen T, Lewandowska A, Choi J, Markgraf D, Junker M, Bilgin M, et al. Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic. 2012;13:880-90 pubmed publisher
    ..Finally, we show that ERMES complexes are long-lived, and do not depend on the presence of Gem1. Our findings suggest that the ERMES complex may have primarily a structural role in maintaining mitochondrial morphology. ..
  9. Voss C, Lahiri S, Young B, Loewen C, Prinz W. ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae. J Cell Sci. 2012;125:4791-9 pubmed publisher
  10. Kojima R, Endo T, Tamura Y. A phospholipid transfer function of ER-mitochondria encounter structure revealed in vitro. Sci Rep. 2016;6:30777 pubmed publisher
    ..This in vitro assay system thus offers a powerful tool to analyze the non-vesicular phospholipid transport between the ER and mitochondria. ..
  11. Xue Y, Schmollinger S, Attar N, Campos O, Vogelauer M, Carey M, et al. Endoplasmic reticulum-mitochondria junction is required for iron homeostasis. J Biol Chem. 2017;292:13197-13204 pubmed publisher
    ..Our findings reveal that proper communication between the ER and mitochondria is required for appropriate maintenance of cellular iron levels. ..
  12. Dimmer K, Jakobs S, Vogel F, Altmann K, Westermann B. Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast. J Cell Biol. 2005;168:103-15 pubmed
    ..Mitochondrial DNA (mtDNA) is instable in the mutants, mtDNA nucleoids are disorganized, and their association with Mmm1-containing complexes in the outer membrane is abolished...
  13. Jeong H, Park J, Lee C. Crystal structure of Mdm12 reveals the architecture and dynamic organization of the ERMES complex. EMBO Rep. 2016;17:1857-1871 pubmed
    ..The ERMES complex is composed of Mdm12, Mmm1, and Mdm34, which have a SMP domain in common, and Mdm10. Here, we report the crystal structure of S...