Gene Symbol: MIX17
Alias: MIC17, Mix17p
Species: Saccharomyces cerevisiae S288c
Gabriel K, Milenkovic D, Chacinska A, Müller J, Guiard B, Pfanner N, et al
. Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway. J Mol Biol. 2007;365:612-20 pubmed
..Mdm35, Mic14 (YDR031w) and Mic17 (YMR002w) require the two essential subunits, Mia40 and Erv1, of the MIA machinery for their localization in the ..
Longen S, Bien M, Bihlmaier K, Kloeppel C, Kauff F, Hammermeister M, et al
. Systematic analysis of the twin cx(9)c protein family. J Mol Biol. 2009;393:356-68 pubmed publisher
Bragoszewski P, Gornicka A, Sztolsztener M, Chacinska A. The ubiquitin-proteasome system regulates mitochondrial intermembrane space proteins. Mol Cell Biol. 2013;33:2136-48 pubmed publisher
..Thus, the ubiquitin-proteasome system plays an important role in determining the levels of proteins targeted to the intermembrane space of mitochondria. ..
Gornicka A, Bragoszewski P, Chrościcki P, Wenz L, Schulz C, Rehling P, et al
. A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria. Mol Biol Cell. 2014;25:3999-4009 pubmed publisher
..Thus MIA-dependent proteins take another route across the outer mitochondrial membrane that involves Tom40 in a form that is different from the canonical TOM complex. ..
Wrobel L, Topf U, Bragoszewski P, Wiese S, Sztolsztener M, Oeljeklaus S, et al
. Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Nature. 2015;524:485-8 pubmed publisher
..UPRam provides a means for buffering the consequences of physiological slowdown in mitochondrial protein import and for counteracting pathologies that are caused or contributed by mitochondrial dysfunction. ..