Gene Symbol: MIR1
Species: Saccharomyces cerevisiae S288c
Schroers A, Kramer R, Wohlrab H. The reversible antiport-uniport conversion of the phosphate carrier from yeast mitochondria depends on the presence of a single cysteine. J Biol Chem. 1997;272:10558-64 pubmed
..e. two cysteines in the functionally active dimer. The consequences of this result with respect to a functional model of the carrier protein are discussed. ..
Buttner S, Ruli D, Vögtle F, Galluzzi L, Moitzi B, Eisenberg T, et al
. A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis. EMBO J. 2011;30:2779-92 pubmed publisher
..cell death and disruption of the mitochondrial transmembrane potential via the mitochondrial phosphate carrier Mir1p. Deletion of Mir1p and depletion of its human orthologue (SLC25A3/PHC) abolish stress-induced mitochondrial ..
Dietmeier K, Zara V, Palmisano A, Palmieri F, Voos W, Schlossmann J, et al
. Targeting and translocation of the phosphate carrier/p32 to the inner membrane of yeast mitochondria. J Biol Chem. 1993;268:25958-64 pubmed
..Yeast PiC/p32 is thus not only structurally homologous to the ADP/ATP carrier, but has a similar targeting mechanism and submitochondrial location, supporting its classification as a member of the inner membrane carrier family. ..
Brandina I, Graham J, Lemaitre Guillier C, Entelis N, Krasheninnikov I, Sweetlove L, et al
. Enolase takes part in a macromolecular complex associated to mitochondria in yeast. Biochim Biophys Acta. 2006;1757:1217-28 pubmed
..This suggests an unsuspected novel function for this complex in tRNA mitochondrial import. ..
Seguin A, Santos R, Pain D, Dancis A, Camadro J, Lesuisse E. Co-precipitation of phosphate and iron limits mitochondrial phosphate availability in Saccharomyces cerevisiae lacking the yeast frataxin homologue (YFH1). J Biol Chem. 2011;286:6071-9 pubmed publisher
..Overexpressing the major mitochondrial phosphate carrier, MIR1, slightly increased the concentration of soluble mitochondrial phosphate and significantly improved various ..
Lauffer S, Mäbert K, Czupalla C, Pursche T, Hoflack B, Rödel G, et al
. Saccharomyces cerevisiae porin pore forms complexes with mitochondrial outer membrane proteins Om14p and Om45p. J Biol Chem. 2012;287:17447-58 pubmed publisher
..We propose a model for the role of the two OM proteins in addressing the porin pore to bind to specific channels in the mt IM to facilitate transport of metabolites. ..