MIG1

Summary

Gene Symbol: MIG1
Description: transcription factor MIG1
Alias: CAT4, SSN1, TDS22, transcription factor MIG1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Needham P, Trumbly R. In vitro characterization of the Mig1 repressor from Saccharomyces cerevisiae reveals evidence for monomeric and higher molecular weight forms. Yeast. 2006;23:1151-66 pubmed
    The Mig1 DNA-binding protein of Saccharomyces cerevisiae was expressed and purified from yeast and the physical properties were characterized by several methods, including gel filtration, sucrose gradient sedimentation and native gel ..
  2. Karunanithi S, Cullen P. The filamentous growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 transcriptional repressors in Saccharomyces cerevisiae. Genetics. 2012;192:869-87 pubmed publisher
    ..Opy2 uncovered new interacting partners including a transcriptional repressor that functions in the AMPK pathway, Mig1, and its close functional homolog, Mig2...
  3. Schüller H, Entian K. Extragenic suppressors of yeast glucose derepression mutants leading to constitutive synthesis of several glucose-repressible enzymes. J Bacteriol. 1991;173:2045-52 pubmed
    ..Most revertants belonged to a single complementation group called cat4. This recessive mutation caused a defect in glucose repression of invertase, maltase, and iso-1-cytochrome c...
  4. Treitel M, Carlson M. Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein. Proc Natl Acad Sci U S A. 1995;92:3132-6 pubmed
    ..Here we present evidence that MIG1, a zinc-finger protein in the EGR1/Zif268 family, recruits SSN6-TUP1 to glucose-repressed promoters...
  5. Treitel M, Kuchin S, Carlson M. Snf1 protein kinase regulates phosphorylation of the Mig1 repressor in Saccharomyces cerevisiae. Mol Cell Biol. 1998;18:6273-80 pubmed
    In glucose-grown cells, the Mig1 DNA-binding protein recruits the Ssn6-Tup1 corepressor to glucose-repressed promoters in the yeast Saccharomyces cerevisiae...
  6. De Vit M, Waddle J, Johnston M. Regulated nuclear translocation of the Mig1 glucose repressor. Mol Biol Cell. 1997;8:1603-18 pubmed
    Glucose represses the transcription of many genes in bakers yeast (Saccharomyces cerevisiae). Mig1 is a Cys2-His2 zinc finger protein that mediates glucose repression of several genes by binding to their promoters and recruiting the ..
  7. Harkness T, Shea K, Legrand C, Brahmania M, Davies G. A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast. Genetics. 2004;168:759-74 pubmed
    ..Multicopy expression of genes encoding Snf1p (MIG1) and PKA (PDE2) aging-pathway components suppressed apc5CA phenotypes, suggesting their involvement in APC-..
  8. Papamichos Chronakis M, Gligoris T, Tzamarias D. The Snf1 kinase controls glucose repression in yeast by modulating interactions between the Mig1 repressor and the Cyc8-Tup1 co-repressor. EMBO Rep. 2004;5:368-72 pubmed
    ..The yeast Snf1 kinase, the Mig1 DNA-binding repressor and the Mig1-interacting co-repressor complex Cyc8(Ssn6)-Tup1 are central components of this ..
  9. Lutfiyya L, Iyer V, DeRisi J, DeVit M, Brown P, Johnston M. Characterization of three related glucose repressors and genes they regulate in Saccharomyces cerevisiae. Genetics. 1998;150:1377-91 pubmed
    b>Mig1 and Mig2 are proteins with similar zinc fingers that are required for glucose repression of SUC2 expression. Mig1, but not Mig2, is required for repression of some other glucose-repressed genes, including the GAL genes...

More Information

Publications69

  1. DeVit M, Johnston M. The nuclear exportin Msn5 is required for nuclear export of the Mig1 glucose repressor of Saccharomyces cerevisiae. Curr Biol. 1999;9:1231-41 pubmed
    b>Mig1 is a transcriptional repressor responsible for glucose repression of many genes in the budding yeast Saccharomyces cerevisiae...
  2. Smith F, Davies S, Wilson W, Carling D, Hardie D. The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1. FEBS Lett. 1999;453:219-23 pubmed
    ..The latter three are exact matches to the recognition motif we previously defined for SNF1 and lie within regions shown to be required for SNF1-dependent derepression and nuclear-to-cytoplasmic translocation. ..
  3. Klein C, Rasmussen J, Rønnow B, Olsson L, Nielsen J. Investigation of the impact of MIG1 and MIG2 on the physiology of Saccharomyces cerevisiae. J Biotechnol. 1999;68:197-212 pubmed
    The gene functions of MIG1 and MIG2 are well known for their role in glucose control in Saccharomyces cerevisiae. A prototrophic mig1 disruptant (T468) and mig1mig2 double disruptant (T475) as well as their congenic wild-type strain (CEN...
  4. Cao H, Yue M, Li S, Bai X, Zhao X, Du Y. The impact of MIG1 and/or MIG2 disruption on aerobic metabolism of succinate dehydrogenase negative Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2011;89:733-8 pubmed publisher
    The zinc finger proteins Mig1 and Mig2 play important roles in glucose repression of Saccharomyces cerevisiae...
  5. Ahuatzi D, Riera A, Pelaez R, Herrero P, Moreno F. Hxk2 regulates the phosphorylation state of Mig1 and therefore its nucleocytoplasmic distribution. J Biol Chem. 2007;282:4485-93 pubmed
    b>Mig1 and Hxk2 are two major mediators of glucose repression in Saccharomyces cerevisiae. However, the mechanism by which Hxk2 participates in the glucose repression signaling pathway is not completely understood...
  6. Sarma N, Haley T, Barbara K, Buford T, Willis K, Santangelo G. Glucose-responsive regulators of gene expression in Saccharomyces cerevisiae function at the nuclear periphery via a reverse recruitment mechanism. Genetics. 2007;175:1127-35 pubmed
    ..Strikingly, SUC2 is both derepressed and confined to the nuclear rim in mutant cells where the Mig1 repressor is nuclear but not perinuclear...
  7. Lundin M, Nehlin J, Ronne H. Importance of a flanking AT-rich region in target site recognition by the GC box-binding zinc finger protein MIG1. Mol Cell Biol. 1994;14:1979-85 pubmed
    b>MIG1 is a zinc finger protein that mediates glucose repression in the yeast Saccharomyces cerevisiae. MIG1 is related to the mammalian Krox/Egr, Wilms' tumor, and Sp1 finger proteins...
  8. Carlson M, Osmond B, Neigeborn L, Botstein D. A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast. Genetics. 1984;107:19-32 pubmed
    ..showed that the suppressor mutations were all recessive and defined eight complementation groups, designated ssn1 through ssn8 (suppressor of snf1 )...
  9. Zhou H, Winston F. NRG1 is required for glucose repression of the SUC2 and GAL genes of Saccharomyces cerevisiae. BMC Genet. 2001;2:5 pubmed
    ..Saccharomyces cerevisiae, has been shown to be controlled by several factors, including two repressors called Mig1 and Mig2. Past results suggest that other repressors may be involved in glucose repression...
  10. Ahuatzi D, Herrero P, de la Cera T, Moreno F. The glucose-regulated nuclear localization of hexokinase 2 in Saccharomyces cerevisiae is Mig1-dependent. J Biol Chem. 2004;279:14440-6 pubmed
    Two major mediators of glucose repression in Saccharomyces cerevisiae are the proteins Mig1 and Hxk2...
  11. Westholm J, Nordberg N, Murén E, Ameur A, Komorowski J, Ronne H. Combinatorial control of gene expression by the three yeast repressors Mig1, Mig2 and Mig3. BMC Genomics. 2008;9:601 pubmed publisher
    Expression of a large number of yeast genes is repressed by glucose. The zinc finger protein Mig1 is the main effector in glucose repression, but yeast also has two related proteins: Mig2 and Mig3...
  12. Vallier L, Carlson M. Synergistic release from glucose repression by mig1 and ssn mutations in Saccharomyces cerevisiae. Genetics. 1994;137:49-54 pubmed
    ..mig1 partially restores SUC2 expression in mutants lacking the SNF1 protein kinase and show that mig1 is allelic to ssn1, a mutation selected as a suppressor of snf1...
  13. Nehlin J, Carlberg M, Ronne H. Control of yeast GAL genes by MIG1 repressor: a transcriptional cascade in the glucose response. EMBO J. 1991;10:3373-7 pubmed
    ..Thus, GAL4, which encodes an activator of the GAL genes, is repressed by MIG1, a zinc finger protein that binds to the GAL4 promoter...
  14. Peiró Chova L, Estruch F. The yeast RNA polymerase II-associated factor Iwr1p is involved in the basal and regulated transcription of specific genes. J Biol Chem. 2009;284:28958-67 pubmed publisher
  15. Parua P, Young E. Binding and transcriptional regulation by 14-3-3 (Bmh) proteins requires residues outside of the canonical motif. Eukaryot Cell. 2014;13:21-30 pubmed publisher
    ..Bmh binding to the Adr1 regulatory domain, and its failure to bind when mutations are present, explains at a molecular level the transcriptional phenotype of ADR1(c) mutants. ..
  16. Vega M, Riera A, Fernández Cid A, Herrero P, Moreno F. Hexokinase 2 Is an Intracellular Glucose Sensor of Yeast Cells That Maintains the Structure and Activity of Mig1 Protein Repressor Complex. J Biol Chem. 2016;291:7267-85 pubmed publisher
    ..theSUC2promoter context, Hxk2 functions through a variety of structurally unrelated factors, mainly the DNA-binding Mig1 and Mig2 repressors and the regulatory Snf1 and Reg1 factors...
  17. Chandrashekarappa D, McCartney R, O Donnell A, Schmidt M. The ? subunit of yeast AMP-activated protein kinase directs substrate specificity in response to alkaline stress. Cell Signal. 2016;28:1881-1893 pubmed publisher
    ..The effect of low glucose and alkaline stresses was examined for two Snf1 phosphorylation substrates, the Mig1 and Mig2 proteins. Any of the three isoforms was capable of phosphorylating Mig1 in response to glucose stress...
  18. Wu J, Trumbly R. Multiple regulatory proteins mediate repression and activation by interaction with the yeast Mig1 binding site. Yeast. 1998;14:985-1000 pubmed
    A major mediator of glucose repression in yeast is Mig1, a zinc finger protein that binds to a GC-rich recognition sequence found upstream of many glucose-repressible genes...
  19. Deroover S, Ghillebert R, Broeckx T, Winderickx J, Rolland F. Trehalose-6-phosphate synthesis controls yeast gluconeogenesis downstream and independent of SNF1. FEMS Yeast Res. 2016;16: pubmed publisher
    ..While SNF1 is essential for induction of gluconeogenesis, T6P/TPS is required for inactivation of gluconeogenesis in the presence of glucose, downstream and independent of SNF1 activity and the Cat8 and Sip4 transcription factors. ..
  20. Munson A, Haydon D, Love S, Fell G, Palanivel V, Rosenwald A. Yeast ARL1 encodes a regulator of K+ influx. J Cell Sci. 2004;117:2309-20 pubmed
    ..These results are consistent with a model in which ARL1, via regulation of HAL4/HAL5, governs K(+) homeostasis in cells. ..
  21. Wade S, Poorey K, Bekiranov S, Auble D. The Snf1 kinase and proteasome-associated Rad23 regulate UV-responsive gene expression. EMBO J. 2009;28:2919-31 pubmed publisher
    ..These results also highlight how diverse environmental stimuli are processed by a limited repertoire of signalling molecules to result in tailored patterns of gene expression. ..
  22. Nath N, McCartney R, Schmidt M. Purification and characterization of Snf1 kinase complexes containing a defined Beta subunit composition. J Biol Chem. 2002;277:50403-8 pubmed
    ..as judged by their ability to phosphorylate a recombinant protein containing the Snf1-responsive domain of the Mig1 protein...
  23. Hazbun T, Fields S. A genome-wide screen for site-specific DNA-binding proteins. Mol Cell Proteomics. 2002;1:538-43 pubmed
    ..Three transcription factors, Mig1, Yer028c, and Rgt1, were found to be binding activities specific to the SUC2 UAS...
  24. Elbing K, McCartney R, Schmidt M. Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae. Biochem J. 2006;393:797-805 pubmed
    ..Finally, we showed that the Snf1 kinase domain isolated from bacteria as a GST fusion protein can be activated in vitro and shows substrate specificity in the absence of its beta and gamma subunits. ..
  25. Chandrashekarappa D, McCartney R, Schmidt M. Ligand binding to the AMP-activated protein kinase active site mediates protection of the activation loop from dephosphorylation. J Biol Chem. 2013;288:89-98 pubmed publisher
  26. Balciunas D, Ronne H. Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells. Mol Gen Genet. 1999;262:589-99 pubmed
    ..SRB10, in budding yeast causes a reduction in expression of the GAL genes, which is particularly pronounced in a mig1 snf1 background...
  27. Elbing K, Rubenstein E, McCartney R, Schmidt M. Subunits of the Snf1 kinase heterotrimer show interdependence for association and activity. J Biol Chem. 2006;281:26170-80 pubmed
  28. Adhikari H, Cullen P. Metabolic respiration induces AMPK- and Ire1p-dependent activation of the p38-Type HOG MAPK pathway. PLoS Genet. 2014;10:e1004734 pubmed publisher
    ..Thus, an evolutionarily conserved regulatory axis links metabolic respiration and AMPK to Ire1p, which regulates a differentiation response involving the modulated activity of ERK and p38 MAPK pathways. ..
  29. Song W, Carlson M. Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1. EMBO J. 1998;17:5757-65 pubmed
    ..We propose that Sfl1, when bound to its site, interacts with Srb/mediator proteins to inhibit transcription by RNA polymerase II holoenzyme. ..
  30. Wang Z, Bai X, Guo X, He X. Regulation of crucial enzymes and transcription factors on 2-phenylethanol biosynthesis via Ehrlich pathway in Saccharomyces cerevisiae. J Ind Microbiol Biotechnol. 2017;44:129-139 pubmed publisher
    ..Furthermore, influence of transcription factors Cat8 and Mig1 on 2-PE biosynthesis was explored...
  31. Song W, Treich I, Qian N, Kuchin S, Carlson M. SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3, and SRB proteins associated with RNA polymerase II. Mol Cell Biol. 1996;16:115-20 pubmed
    ..We also show that SSN4 and SSN7 are the same as SIN4 and ROX3, respectively, raising the possibility that these genes also encode mediator proteins. ..
  32. Riera A, Ahuatzi D, Herrero P, Garcia Gimeno M, Sanz P, Moreno F. Human pancreatic beta-cell glucokinase: subcellular localization and glucose repression signalling function in the yeast cell. Biochem J. 2008;415:233-9 pubmed publisher
    ..study we report that GK(beta) exerts its regulatory role by association with the yeast transcriptional repressor Mig1 (multicopy inhibitor of GAL gene expression 1); the presence of Mig1 allows GK(beta) to bind to the SUC2 (sucrose ..
  33. Yao Y, Tsuchiyama S, Yang C, Bulteau A, He C, Robison B, et al. Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1. PLoS Genet. 2015;11:e1004968 pubmed publisher
    ..premature induction of respiration in cells with increased proteasome activity originates from enhanced turnover of Mig1, an AMPK/Snf1 regulated transcriptional repressor that prevents the induction of genes required for respiration...
  34. Salgado A, Schuller D, Casal M, Leao C, Leiper F, Carling D, et al. Relationship between protein kinase C and derepression of different enzymes. FEBS Lett. 2002;532:324-32 pubmed
    ..of an additional mutation in the PKC1 gene in yeast strains already presenting mutations in the HXKII or MIG1 genes does not interfere with the typical derepressed phenotype observed in these single mutants...
  35. Leech A, Nath N, McCartney R, Schmidt M. Isolation of mutations in the catalytic domain of the snf1 kinase that render its activity independent of the snf4 subunit. Eukaryot Cell. 2003;2:265-73 pubmed
  36. Proft M, Serrano R. Repressors and upstream repressing sequences of the stress-regulated ENA1 gene in Saccharomyces cerevisiae: bZIP protein Sko1p confers HOG-dependent osmotic regulation. Mol Cell Biol. 1999;19:537-46 pubmed
    ..Its function was abolished in a mig1 mig2 double-deletion strain as well as in either ssn6 or tup1 single mutants...
  37. Becuwe M, Vieira N, Lara D, Gomes Rezende J, Soares Cunha C, Casal M, et al. A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis. J Cell Biol. 2012;196:247-59 pubmed publisher
  38. Jin C, Barrientos A, Epstein C, Butow R, Tzagoloff A. SIT4 regulation of Mig1p-mediated catabolite repression in Saccharomyces cerevisiae. FEBS Lett. 2007;581:5658-63 pubmed
    ..The presence of normal levels of MIG1 mRNA in the mutant and its association with the polysome fraction suggests that depletion of Mig1p is the result of ..
  39. Nehlin J, Carlberg M, Ronne H. Yeast SKO1 gene encodes a bZIP protein that binds to the CRE motif and acts as a repressor of transcription. Nucleic Acids Res. 1992;20:5271-8 pubmed
    ..SKO1 interacts positively with MIG1, a zinc finger protein that mediates glucose repression of SUC2...
  40. Bonander N, Ferndahl C, Mostad P, Wilks M, Chang C, Showe L, et al. Transcriptome analysis of a respiratory Saccharomyces cerevisiae strain suggests the expression of its phenotype is glucose insensitive and predominantly controlled by Hap4, Cat8 and Mig1. BMC Genomics. 2008;9:365 pubmed publisher
    ..in our dataset by examining previously-published biological data for Hap4 (in complex with Hap2, 3, 5), Cat8 and Mig1, and used this in combination with verified binding consensus sequences to identify genes likely to be regulated by ..
  41. Zhao Y, Xiong B, Xu H, Jiang L. Expression of NYV1 encoding the negative regulator of Pmc1 is repressed by two transcriptional repressors, Nrg1 and Mig1. FEBS Lett. 2014;588:3195-201 pubmed publisher
    ..Expression of NYV1 is dramatically reduced in ESCRT mutants. Promoter analysis demonstrates that both Nrg1 and Mig1 repress NYV1 expression. Deletion of ESCRTs increases Nrg1 binding, but not Mig1-binding, to the NYV1 promoter...
  42. Garipler G, Mutlu N, Lack N, Dunn C. Deletion of conserved protein phosphatases reverses defects associated with mitochondrial DNA damage in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2014;111:1473-8 pubmed publisher
    ..Our work highlights the important role that nutrient-responsive signaling pathways can play in determining the response to mitochondrial dysfunction. ..
  43. Lin X, Zhang C, Bai X, Song H, Xiao D. Effects of MIG1, TUP1 and SSN6 deletion on maltose metabolism and leavening ability of baker's yeast in lean dough. Microb Cell Fact. 2014;13:93 pubmed publisher
    ..Even if the general repression system constituted by MIG1, TUP1 and SSN6 factors has already been reported, the functions of these three genes in maltose metabolism remain ..
  44. Hohmann S, Huse K, Valentin E, Mbonyi K, Thevelein J, Zimmermann F. Glucose-induced regulatory defects in the Saccharomyces cerevisiae byp1 growth initiation mutant and identification of MIG1 as a partial suppressor. J Bacteriol. 1992;174:4183-8 pubmed
    ..resulted in the isolation of a truncated form of the previously described zinc finger transcription repressor MIG1. The entire MIG1 gene and the truncated form suppressed even on a single-copy vector the growth initiation defect ..
  45. Pelaez R, Herrero P, Moreno F. Functional domains of yeast hexokinase 2. Biochem J. 2010;432:181-90 pubmed publisher
    ..it functions as a glycolytic enzyme in the cytoplasm and as a regulator of gene transcription of several Mig1-regulated genes in the nucleus...
  46. Alberti A, Lodi T, Ferrero I, Donnini C. MIG1-dependent and MIG1-independent regulation of GAL gene expression in Saccharomyces cerevisiae: role of Imp2p. Yeast. 2003;20:1085-96 pubmed
    ..The effect of Imp2 on galactose metabolism was shown to be partially dependent on Mig1p. The Mig1-independent role depends on Nrg1p...
  47. Hu Z, Yue Y, Jiang H, Zhang B, Sherwood P, Michels C. Analysis of the mechanism by which glucose inhibits maltose induction of MAL gene expression in Saccharomyces. Genetics. 2000;154:121-32 pubmed
    ..Previously, we showed that the Mig1 repressor mediates glucose repression of MAL gene expression...
  48. Wang X, Michels C. Mutations in SIN4 and RGR1 cause constitutive expression of MAL structural genes in Saccharomyces cerevisiae. Genetics. 2004;168:747-57 pubmed
    ..A sin4Delta mutation is unable to suppress the defects in MAL gene expression resulting from loss of the Swi/Snf complex component Snf2p. The role of the Mediator in MAL gene regulation is discussed. ..
  49. Almquist J, Bendrioua L, Adiels C, Goksör M, Hohmann S, Jirstrand M. A Nonlinear Mixed Effects Approach for Modeling the Cell-To-Cell Variability of Mig1 Dynamics in Yeast. PLoS ONE. 2015;10:e0124050 pubmed publisher
    ..of NLME modeling to study cell-to-cell variability in the dynamic behavior of the yeast transcription repressor Mig1. In particular, we investigate a recently discovered phenomenon where Mig1 during a short and transient period ..
  50. Puria R, Mannan M, Chopra Dewasthaly R, Ganesan K. Critical role of RPI1 in the stress tolerance of yeast during ethanolic fermentation. FEMS Yeast Res. 2009;9:1161-71 pubmed publisher
    ..As the RPI1 overexpression strain substantially retains cell viability at the end of fermentation, the cells can be reused in the subsequent round of fermentation, which is likely to facilitate economical production of ethanol. ..
  51. Rahner A, Scholer A, Martens E, Gollwitzer B, Schüller H. Dual influence of the yeast Cat1p (Snf1p) protein kinase on carbon source-dependent transcriptional activation of gluconeogenic genes by the regulatory gene CAT8. Nucleic Acids Res. 1996;24:2331-7 pubmed
    ..Thus, biosynthetic control of CAT8 as well as transcriptional activation by Cat8p requires a functional Cat1p protein kinase. A model proposing CAT8 as a specific activator of a transcription factor(s) binding to the CSRE is discussed. ..
  52. Zhang M, Galdieri L, Vancura A. The yeast AMPK homolog SNF1 regulates acetyl coenzyme A homeostasis and histone acetylation. Mol Cell Biol. 2013;33:4701-17 pubmed publisher
  53. Sarma N, Buford T, Haley T, Barbara Haley K, Santangelo G, Willis K. The nuclear pore complex mediates binding of the Mig1 repressor to target promoters. PLoS ONE. 2011;6:e27117 pubmed publisher
    ..Saccharomyces cerevisiae, the best-studied downstream effector of this response is the glucose-regulated repressor Mig1. We show here that nuclear pore complexes also contribute to glucose-regulated gene expression...
  54. Verma M, Bhat P, Venkatesh K. Steady-state analysis of glucose repression reveals hierarchical expression of proteins under Mig1p control in Saccharomyces cerevisiae. Biochem J. 2005;388:843-9 pubmed
    ..A critical feature of repression predicted by our steady-state model for the mutant strain of S. cerevisiae lacking Gal80p agrees well with the data reported here as well as that available in the literature. ..
  55. Nath N, McCartney R, Schmidt M. Yeast Pak1 kinase associates with and activates Snf1. Mol Cell Biol. 2003;23:3909-17 pubmed
    ..activity in vitro, and affinity-purified Pak1 kinase is able to activate the Snf1-dependent phosphorylation of Mig1 in vitro...
  56. Shankar C, Ramakrishnan M, Umesh Kumar S. MIG1 overexpression causes flocculation in Saccharomyces cerevisiae. Microbiology. 1996;142 ( Pt 9):2663-7 pubmed
    b>MIG1, encoding a C2H2 zinc-finger repressor protein involved in carbon catabolite repression, was found to play a role in non-sexual flocculation of Saccharomyces cerevisiae...
  57. Luyten K, Albertyn J, Skibbe W, Prior B, Ramos J, Thevelein J, et al. Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. EMBO J. 1995;14:1360-71 pubmed
    ..We conclude that Fps1 is a regulated yeast glycerol facilitator controlling glycerol production and cytosolic concentration, and might have additional functions. ..
  58. Shashkova S, Wollman A, Leake M, Hohmann S. The yeast Mig1 transcriptional repressor is dephosphorylated by glucose-dependent and -independent mechanisms. FEMS Microbiol Lett. 2017;364: pubmed publisher
    ..derepression of genes required for utilization of alternative carbon sources through the transcriptional repressor Mig1. It has been suggested that the Glc7-Reg1 phosphatase dephosphorylates Mig1...
  59. Tedrick K, Trischuk T, Lehner R, Eitzen G. Enhanced membrane fusion in sterol-enriched vacuoles bypasses the Vrp1p requirement. Mol Biol Cell. 2004;15:4609-21 pubmed
    ..Therefore, the Vrp1p/Las17p requirement for membrane fusion is bypassed by increased sterols, which promotes actin remodeling as part the membrane fusion mechanism. ..
  60. McCartney R, Garnar Wortzel L, Chandrashekarappa D, Schmidt M. Activation and inhibition of Snf1 kinase activity by phosphorylation within the activation loop. Biochim Biophys Acta. 2016;1864:1518-28 pubmed publisher
    ..The first is through direct dephosphorylation of the conserved activation loop threonine. The second is through phosphorylation of serine 214. ..