Gene Symbol: MIC12
Alias: AIM5, FMP51, MCS12, Mic12p
Species: Saccharomyces cerevisiae S288c
Harner M, Korner C, Walther D, Mokranjac D, Kaesmacher J, Welsch U, et al
. The mitochondrial contact site complex, a determinant of mitochondrial architecture. EMBO J. 2011;30:4356-70 pubmed publisher
..Loss of MICOS subunits results in loss of respiratory competence and altered inheritance of mitochondrial DNA. ..
Zerbes R, Bohnert M, Stroud D, von der Malsburg K, Kram A, Oeljeklaus S, et al
. Role of MINOS in mitochondrial membrane architecture: cristae morphology and outer membrane interactions differentially depend on mitofilin domains. J Mol Biol. 2012;422:183-91 pubmed publisher
Bohnert M, Wenz L, Zerbes R, Horvath S, Stroud D, von der Malsburg K, et al
. Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane. Mol Biol Cell. 2012;23:3948-56 pubmed publisher
..We conclude that MINOS interacts with TOM and SAM independently and that the core subunit mitofilin is involved in biogenesis of outer membrane ?-barrel proteins. ..
Harner M, Unger A, Izawa T, Walther D, Ozbalci C, Geimer S, et al
. Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. elife. 2014;3:e01684 pubmed publisher
..Modification of MICOS subunits Mic12 or Mic26 by His-tags in the absence of Aim24 leads to complete loss of cristae and respiratory complexes...
Zerbes R, HÃ¶ÃŸ P, Pfanner N, van der Laan M, Bohnert M. Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System. J Mol Biol. 2016;428:1485-92 pubmed publisher
..a Mic60-Mic19 subcomplex that forms Mic60-mediated contact sites with the outer mitochondrial membrane and a Mic10-Mic12-Mic26-Mic27 membrane-sculpting subcomplex that contains large Mic10 oligomers...
Chojnacka M, Gornicka A, Oeljeklaus S, Warscheid B, Chacinska A. Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System. J Biol Chem. 2015;290:15304-12 pubmed publisher
..However, the Cox17-MICOS interaction is regulated by copper ions. We propose that Cox17 is a newly identified factor involved in maintaining the architecture of the MICOS complex. ..