MIC10

Summary

Gene Symbol: MIC10
Description: Mic10p
Alias: MCS10, MIO10, MOS1, Mic10p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Harner M, Korner C, Walther D, Mokranjac D, Kaesmacher J, Welsch U, et al. The mitochondrial contact site complex, a determinant of mitochondrial architecture. EMBO J. 2011;30:4356-70 pubmed publisher
    ..Loss of MICOS subunits results in loss of respiratory competence and altered inheritance of mitochondrial DNA. ..
  2. Zerbes R, Bohnert M, Stroud D, von der Malsburg K, Kram A, Oeljeklaus S, et al. Role of MINOS in mitochondrial membrane architecture: cristae morphology and outer membrane interactions differentially depend on mitofilin domains. J Mol Biol. 2012;422:183-91 pubmed publisher
  3. Itoh K, Tamura Y, Iijima M, Sesaki H. Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology. Mol Biol Cell. 2013;24:1842-51 pubmed publisher
    ..Here, using a yeast genetic screen for components that control nucleoid distribution and size, we identify Fcj1 and Mos1, two evolutionarily conserved mitochondrial proteins that maintain the connection between the cristae and boundary ..
  4. Aaltonen M, Friedman J, Osman C, Salin B, di Rago J, Nunnari J, et al. MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria. J Cell Biol. 2016;213:525-34 pubmed publisher
    ..These results link mitochondrial PE metabolism to MICOS, combining functions in protein and lipid homeostasis to preserve mitochondrial structure and function. ..
  5. Bohnert M, Wenz L, Zerbes R, Horvath S, Stroud D, von der Malsburg K, et al. Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane. Mol Biol Cell. 2012;23:3948-56 pubmed publisher
    ..We conclude that MINOS interacts with TOM and SAM independently and that the core subunit mitofilin is involved in biogenesis of outer membrane ?-barrel proteins. ..
  6. Barbot M, Jans D, Schulz C, Denkert N, Kroppen B, Hoppert M, et al. Mic10 oligomerizes to bend mitochondrial inner membranes at cristae junctions. Cell Metab. 2015;21:756-63 pubmed publisher
    ..Here we identify Mic10, a core subunit of the recently discovered MICOS complex, as an inner mitochondrial membrane protein with the ..
  7. Harner M, Unger A, Izawa T, Walther D, Ozbalci C, Geimer S, et al. Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. elife. 2014;3:e01684 pubmed publisher
    ..In conclusion, Aim24 by interacting with the MICOS complex plays a key role in mitochondrial architecture, composition and function. DOI: http://dx.doi.org/10.7554/eLife.01684.001. ..
  8. Harner M, Unger A, Geerts W, Mari M, Izawa T, Stenger M, et al. An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation. elife. 2016;5: pubmed publisher
    ..The proposed hypothesis is suggested to apply also to higher eukaryotes, since the key components are conserved in structure and function throughout evolution. ..
  9. Chojnacka M, Gornicka A, Oeljeklaus S, Warscheid B, Chacinska A. Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System. J Biol Chem. 2015;290:15304-12 pubmed publisher
    ..However, the Cox17-MICOS interaction is regulated by copper ions. We propose that Cox17 is a newly identified factor involved in maintaining the architecture of the MICOS complex. ..

More Information

Publications10

  1. Rampelt H, Bohnert M, Zerbes R, Horvath S, Warscheid B, Pfanner N, et al. Mic10, a Core Subunit of the Mitochondrial Contact Site and Cristae Organizing System, Interacts with the Dimeric F1Fo-ATP Synthase. J Mol Biol. 2017;429:1162-1170 pubmed publisher
    ..We report that the MICOS core subunit Mic10, but not Mic60, binds to the F1Fo-ATP synthase...