MGR2

Summary

Gene Symbol: MGR2
Description: Mgr2p
Alias: Mgr2p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Gebert M, Schrempp S, Mehnert C, Heißwolf A, Oeljeklaus S, Ieva R, et al. Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes. J Cell Biol. 2012;197:595-604 pubmed publisher
    ..We have identified a new subunit of the TIM23 complex, the inner membrane protein Mgr2. Mitochondria lacking Mgr2 were deficient in the Tim21-containing sorting form of the TIM23 complex...
  2. Ieva R, Schrempp S, Opaliński L, Wollweber F, Höß P, Heißwolf A, et al. Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane. Mol Cell. 2014;56:641-52 pubmed publisher
    ..We report that the small hydrophobic protein Mgr2 controls the lateral release of preproteins. Mgr2 interacts with preproteins in transit through the TIM23 complex...
  3. Ieva R, Heißwolf A, Gebert M, Vögtle F, Wollweber F, Mehnert C, et al. Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence. Nat Commun. 2013;4:2853 pubmed publisher
    ..We show that the TIM23 subunit Mgr2 is processed by IMP, but not by MPP...
  4. Schulz C, Rehling P. Remodelling of the active presequence translocase drives motor-dependent mitochondrial protein translocation. Nat Commun. 2014;5:4349 pubmed publisher
    ..Thus, a replenishment cycle of co-chaperones at the TIM23 complex is an integral part of Hsp70's ATPase cycle at the channel exit site and essential to maintain motor-driven mitochondrial protein import. ..
  5. Schendzielorz A, Schulz C, Lytovchenko O, Clancy A, Guiard B, Ieva R, et al. Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation. J Cell Biol. 2017;216:83-92 pubmed publisher
    ..The ??- and Pam17-dependent import step identified in this study is positioned between the two known energy-dependent steps: ??-driven presequence translocation and adenosine triphosphate-driven import motor activity. ..