Gene Symbol: MGM101
Description: Mgm101p
Alias: MGM9, Mgm101p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Meeusen S, Tieu Q, Wong E, Weiss E, Schieltz D, Yates J, et al. Mgm101p is a novel component of the mitochondrial nucleoid that binds DNA and is required for the repair of oxidatively damaged mitochondrial DNA. J Cell Biol. 1999;145:291-304 pubmed
    ..Using liquid chromatography coupled with tandem mass spectrometry, we identified Mgm101p as a component of highly enriched nucleoids, suggesting that it plays a nucleoid-specific role in maintenance...
  2. Kaufman B, Newman S, Hallberg R, Slaughter C, Perlman P, Butow R. In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins. Proc Natl Acad Sci U S A. 2000;97:7772-7 pubmed
    ..These data identify bifunctional proteins that participate in the stability of rho(+) mtDNA. ..
  3. Zuo X, Clark Walker G, Chen X. The mitochondrial nucleoid protein, Mgm101p, of Saccharomyces cerevisiae is involved in the maintenance of rho(+) and ori/rep-devoid petite genomes but is not required for hypersuppressive rho(-) mtDNA. Genetics. 2002;160:1389-400 pubmed
    The Saccharomyces cerevisiae MGM101 gene encodes a DNA-binding protein targeted to mitochondrial nucleoids...
  4. Zuo X, Xue D, Li N, Clark Walker G. A functional core of the mitochondrial genome maintenance protein Mgm101p in Saccharomyces cerevisiae determined with a temperature-conditional allele. FEMS Yeast Res. 2007;7:131-40 pubmed
    Analysis of Mgm101p isolated from mitochondria shows that the mature protein of 27.6 kDa lacks 22 amino acids from the N-terminus...
  5. Mbantenkhu M, Wang X, Nardozzi J, Wilkens S, Hoffman E, Patel A, et al. Mgm101 is a Rad52-related protein required for mitochondrial DNA recombination. J Biol Chem. 2011;286:42360-70 pubmed publisher
    ..Here, we show that the yeast mitochondrial nucleoid protein, Mgm101, is related to the Rad52-type recombination proteins that are widespread in organisms from bacteriophage to humans...
  6. Meeusen S, Nunnari J. Evidence for a two membrane-spanning autonomous mitochondrial DNA replisome. J Cell Biol. 2003;163:503-10 pubmed
    ..Taken together, our observations reveal the existence of an autonomous two membrane-spanning mitochondrial replisome as well as provide a mechanism for how mtDNA replication and inheritance may be physically linked. ..
  7. Ward T, Dudasova Z, Sarkar S, Bhide M, Vlasáková D, Chovanec M, et al. Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast. PLoS Genet. 2012;8:e1002884 pubmed publisher
    ..We find that the yeast FANCM ortholog Mph1 physically and functionally interacts with Mgm101, a protein previously implicated in mitochondrial DNA repair, and the MutS? mismatch repair factor (Msh2-Msh6)...
  8. Nardozzi J, Wang X, Mbantenkhu M, Wilkens S, Chen X. A properly configured ring structure is critical for the function of the mitochondrial DNA recombination protein, Mgm101. J Biol Chem. 2012;287:37259-68 pubmed publisher
    b>Mgm101 is a Rad52-type recombination protein of bacteriophage origin required for the repair and maintenance of mitochondrial DNA (mtDNA)...
  9. Hayward D, Dosztanyi Z, Clark Walker G. The N-terminal intrinsically disordered domain of Mgm101p is localized to the mitochondrial nucleoid. PLoS ONE. 2013;8:e56465 pubmed publisher
    ..Previously, in Saccharomyces cerevisiae, it has been found that the carboxy-terminal two-thirds of Mgm101p has a functional core...

More Information


  1. Chen X, Wang X, Kaufman B, Butow R. Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science. 2005;307:714-7 pubmed
    ..When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance. ..
  2. Markov D, Savkina M, Anikin M, Del Campo M, Ecker K, Lambowitz A, et al. Identification of proteins associated with the yeast mitochondrial RNA polymerase by tandem affinity purification. Yeast. 2009;26:423-40 pubmed publisher
    ..Further, we found that Mss116p inhibits transcription by mtRNAP in vitro in a steady-state reaction. Our results support the hypothesis that Mss116p and Pet127p are involved in modulation of mtRNAP activity. ..
  3. Mbantenkhu M, Wierzbicki S, Wang X, Guo S, Wilkens S, Chen X. A short carboxyl-terminal tail is required for single-stranded DNA binding, higher-order structural organization, and stability of the mitochondrial single-stranded annealing protein Mgm101. Mol Biol Cell. 2013;24:1507-18 pubmed publisher
    b>Mgm101 is a Rad52-type single-stranded annealing protein (SSAP) required for mitochondrial DNA (mtDNA) repair and maintenance. Structurally, Mgm101 forms large oligomeric rings...
  4. Silva S, Altmannova V, Luke Glaser S, Henriksen P, Gallina I, Yang X, et al. Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Genes Dev. 2016;30:700-17 pubmed publisher
    ..Taken together, our data indicate that Mte1 plays a role in regulation of crossover recombination, response to replication stress, and telomere maintenance. ..
  5. Rendeková J, Ward T, Simonicova L, Thomas P, Nosek J, Tomaska L, et al. Mgm101: A double-duty Rad52-like protein. Cell Cycle. 2016;15:3169-3176 pubmed
    b>Mgm101 has well-characterized activity for the repair and replication of the mitochondrial genome...