MET22

Summary

Gene Symbol: MET22
Description: 3'(2'),5'-bisphosphate nucleotidase
Alias: HAL2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc Salt tolerance and methionine biosynthesis in Saccharomyces cerevisiae involve a putative phosphatase gene
    H U Gläser
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 12:3105-10. 1993
  2. ncbi The yeast HAL2 nucleotidase is an in vivo target of salt toxicity
    J R Murguia
    Instituto de Biologia Molecular y Celular de Plantas, Universidad Politecnica de Valencia Consejo Superior de Investigaciones Cientificas, Valencia, Spain
    J Biol Chem 271:29029-33. 1996
  3. pmc Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1
    Irina Chernyakov
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Genes Dev 22:1369-80. 2008
  4. pmc The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications
    Joshua M Dewe
    Department of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    RNA 18:1886-96. 2012
  5. pmc Hal2p functions in Bdf1p-involved salt stress response in Saccharomyces cerevisiae
    Lei Chen
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, China
    PLoS ONE 8:e62110. 2013
  6. ncbi A salt-sensitive 3'(2'),5'-bisphosphate nucleotidase involved in sulfate activation
    J R Murguia
    Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas, Universidad Politecnica de Valencia, Spain
    Science 267:232-4. 1995
  7. ncbi The protein kinase Gcn2p mediates sodium toxicity in yeast
    A Goossens
    Instituto de Biologia Molecular y Celular de Plantas, Universidad Politecnica de Valencia C S I C, Camino de Vera s n, 46022 Valencia, Spain
    J Biol Chem 276:30753-60. 2001
  8. pmc Dosage rescue by UBC4 restores cell wall integrity in Saccharomyces cerevisiae lacking the myosin type II gene MYO1
    NITZA L DIAZ-BLANCO
    Department of Biochemistry, School of Medicine, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936 5067, Puerto Rico
    Yeast 24:343-55. 2007
  9. pmc Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks
    Xionglei He
    Department of Ecology and Evolutionary Biology, Ann Arbor, Michigan, USA
    Nat Genet 42:272-6. 2010
  10. ncbi X-ray structure of yeast Hal2p, a major target of lithium and sodium toxicity, and identification of framework interactions determining cation sensitivity
    A Albert
    Grupo de Cristalografia Macromolecular y Biologia Estructural, Instituto de Quimica Fisica Rocasolano, Consejo Superior de Investigaciones Cientificas, Serrano 119, Madrid, E 28006, Spain
    J Mol Biol 295:927-38. 2000

Scientific Experts

  • Armando Albert
  • Ramon Serrano
  • Irina Chernyakov
  • Lei Chen
  • Joshua M Dewe
  • Xionglei He
  • Eric M Phizicky
  • Joseph M Whipple
  • NITZA L DIAZ-BLANCO
  • Jin Hou
  • Mingpeng Wang
  • Xiaoming Bao
  • Jiafang Fu
  • Zhaojie Zhang
  • Liangyu Liu
  • Laura N Jaramillo
  • A Goossens
  • J R Murguia
  • Ying Li
  • Wenfeng Qian
  • Zhi Wang
  • Jianzhi Zhang
  • Elizabeth J Grayhack
  • Lakmal Kotelawala
  • Jose R Rodriguez-Medina
  • J M Bellés
  • A Pascual-Ahuir
  • T E Dever
  • H U Gläser
  • D Thomas
  • R Gaxiola
  • F Montrichard
  • Y Surdin-Kerjan

Detail Information

Publications10

  1. pmc Salt tolerance and methionine biosynthesis in Saccharomyces cerevisiae involve a putative phosphatase gene
    H U Gläser
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 12:3105-10. 1993
    ..Complementation analysis demonstrated that HAL2 is identical to MET22, a gene involved in methionine biosynthesis...
  2. ncbi The yeast HAL2 nucleotidase is an in vivo target of salt toxicity
    J R Murguia
    Instituto de Biologia Molecular y Celular de Plantas, Universidad Politecnica de Valencia Consejo Superior de Investigaciones Cientificas, Valencia, Spain
    J Biol Chem 271:29029-33. 1996
    The yeast halotolerance gene HAL2 encodes a nucleotidase that dephosphorylates 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS), intermediates of the sulfate assimilation pathway...
  3. pmc Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1
    Irina Chernyakov
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Genes Dev 22:1369-80. 2008
    ..We show here that components of this RTD pathway include the 5'-3' exonucleases Rat1 and Xrn1, and Met22, which likely acts indirectly through Rat1 and Xrn1...
  4. pmc The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications
    Joshua M Dewe
    Department of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    RNA 18:1886-96. 2012
    ..These results demonstrate that RTD interacts with the translation machinery and acts widely on hypomodified tRNAs...
  5. pmc Hal2p functions in Bdf1p-involved salt stress response in Saccharomyces cerevisiae
    Lei Chen
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, China
    PLoS ONE 8:e62110. 2013
    ..Hal2p is also a target of high concentration of Na(+). Here, we reported that HAL2 overexpression recovered the salt stress sensitivity of bdf1Δ...
  6. ncbi A salt-sensitive 3'(2'),5'-bisphosphate nucleotidase involved in sulfate activation
    J R Murguia
    Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas, Universidad Politecnica de Valencia, Spain
    Science 267:232-4. 1995
    Overexpression of a yeast gene, HAL2, allows the cells to tolerate higher than normal extracellular salt concentrations...
  7. ncbi The protein kinase Gcn2p mediates sodium toxicity in yeast
    A Goossens
    Instituto de Biologia Molecular y Celular de Plantas, Universidad Politecnica de Valencia C S I C, Camino de Vera s n, 46022 Valencia, Spain
    J Biol Chem 276:30753-60. 2001
    ..It can be postulated that sodium activation of the Gcn2p pathway has toxic effects on growth under NaCl stress and that this novel mechanism of sodium toxicity may be of general significance in eukaryotes...
  8. pmc Dosage rescue by UBC4 restores cell wall integrity in Saccharomyces cerevisiae lacking the myosin type II gene MYO1
    NITZA L DIAZ-BLANCO
    Department of Biochemistry, School of Medicine, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936 5067, Puerto Rico
    Yeast 24:343-55. 2007
    ..These results point to Ubc4p as an important enzyme in the process of cell wall remodelling in myo1 cells...
  9. pmc Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks
    Xionglei He
    Department of Ecology and Evolutionary Biology, Ann Arbor, Michigan, USA
    Nat Genet 42:272-6. 2010
    ..We offer mechanistic explanations of these findings and experimentally validate them for 61 S. cerevisiae gene pairs...
  10. ncbi X-ray structure of yeast Hal2p, a major target of lithium and sodium toxicity, and identification of framework interactions determining cation sensitivity
    A Albert
    Grupo de Cristalografia Macromolecular y Biologia Estructural, Instituto de Quimica Fisica Rocasolano, Consejo Superior de Investigaciones Cientificas, Serrano 119, Madrid, E 28006, Spain
    J Mol Biol 295:927-38. 2000
    The product of the yeast HAL2 gene (Hal2p) is an in vivo target of sodium and lithium toxicity and its overexpression improves salt tolerance in yeast and plants...