Gene Symbol: MET18
Alias: MMS19, Met18p
Species: Saccharomyces cerevisiae S288c
Gari K, León Ortiz A, Borel V, Flynn H, Skehel J, Boulton S. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Science. 2012;337:243-5 pubmed publisher
..Here, we demonstrate that MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins CIAO1, IOP1, and MIP18...
Stehling O, Vashisht A, Mascarenhas J, Jonsson Z, Sharma T, Netz D, et al
. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Science. 2012;337:195-9 pubmed publisher
Instability of the nuclear genome is a hallmark of cancer and aging. MMS19 protein has been linked to maintenance of genomic integrity, but the molecular basis of this connection is unknown...
Masselot M, De Robichon Szulmajster H. Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants. Mol Gen Genet. 1975;139:121-32 pubmed
..Preliminary to biochemical studies, mutants of each complementation group were tested for their capacity to utilize various precursors of methionine. ..
Chen Y, Liu X, Zhao W, Cui H, Ruan J, Yuan Y, et al
. MET18 Deficiency Increases the Sensitivity of Yeast to Oxidative Stress and Shortens Replicative Lifespan by Inhibiting Catalase Activity. Biomed Res Int. 2017;2017:7587395 pubmed publisher
Yeast MET18, a subunit of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery which is responsible for the maturation of Fe/S proteins, has been reported to participate in the oxidative stress response...
Chanet R, Heude M. Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae. Curr Genet. 2003;43:337-50 pubmed
..Other mutations were identified in genes involved in repair and genome stability (MET18/ MMS19), in the control of origin-firing and/or transcription (ABF1, SRB7), in the S/G2 checkpoint (RAD53), in the Ras-..
Kou H, Zhou Y, Gorospe R, Wang Z. Mms19 protein functions in nucleotide excision repair by sustaining an adequate cellular concentration of the TFIIH component Rad3. Proc Natl Acad Sci U S A. 2008;105:15714-9 pubmed publisher
..We have investigated the role of Mms19 in NER in the yeast Saccharomyces cerevisiae...
Lev I, Volpe M, Goor L, Levinton N, Emuna L, Ben Aroya S. Reverse PCA, a systematic approach for identifying genes important for the physical interaction between protein pairs. PLoS Genet. 2013;9:e1003838 pubmed publisher
..validate this novel approach by identifying mutants that dissociate the conserved interaction between Cia2 and Mms19, two proteins involved in Iron-Sulfur protein biogenesis and genome stability...
Lauder S, Bankmann M, Guzder S, Sung P, Prakash L, Prakash S. Dual requirement for the yeast MMS19 gene in DNA repair and RNA polymerase II transcription. Mol Cell Biol. 1996;16:6783-93 pubmed
..However, how MMS19 affects this process has remained unclear...
James A, Cocheme H, Murai M, Miyoshi H, Murphy M. Complementation of coenzyme Q-deficient yeast by coenzyme Q analogues requires the isoprenoid side chain. FEBS J. 2010;277:2067-82 pubmed publisher
..Here we suggest that CoQ or its redox state may be a signal for growth during the shift to respiration. ..