MER1

Summary

Gene Symbol: MER1
Description: Mer1p
Alias: Mer1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Engebrecht J, Roeder G. Yeast mer1 mutants display reduced levels of meiotic recombination. Genetics. 1989;121:237-47 pubmed
    Mutations at the MER1 locus were identified in a search for meiotic mutants defective in chromosome segregation. mer1 strains show decreased levels of inter- and intrachromosomal meiotic recombination and produce inviable spores...
  2. Nandabalan K, Roeder G. Binding of a cell-type-specific RNA splicing factor to its target regulatory sequence. Mol Cell Biol. 1995;15:1953-60 pubmed
    ..Efficient splicing of the wild-type MER2 transcript requires the Mer1 protein, which is produced only in meiotic cells...
  3. Engebrecht J, Hirsch J, Roeder G. Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation. Cell. 1990;62:927-37 pubmed
    The yeast mer1 mutant produces inviable spores and is defective in both meiotic recombination and chromosome pairing. A gene called MER2 partially suppresses the mer1 phenotype when present in high copy number...
  4. Spingola M, Ares M. A yeast intronic splicing enhancer and Nam8p are required for Mer1p-activated splicing. Mol Cell. 2000;6:329-38 pubmed
    Three introns whose splicing is activated during meiosis in S. cerevisiae contain a Mer1p-dependent splicing enhancer...
  5. Balzer R, Henry M. Snu56p is required for Mer1p-activated meiotic splicing. Mol Cell Biol. 2008;28:2497-508 pubmed publisher
    ..Using a CUP1 reporter assay and reverse transcriptase PCR, we demonstrate that this allele specifically impairs Mer1p-activated splicing...
  6. Malone R, Bullard S, Hermiston M, Rieger R, Cool M, Galbraith A. Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics. 1991;128:79-88 pubmed
    ..Analysis of 56 of these has generated alleles of the known Rec genes SPO11, ME14 and MER1, as well as defining five new genes: REC102, REC104, REC107, REC113 and REC114...
  7. Spingola M, Armisen J, Ares M. Mer1p is a modular splicing factor whose function depends on the conserved U2 snRNP protein Snu17p. Nucleic Acids Res. 2004;32:1242-50 pubmed
    b>Mer1p activates the splicing of at least three pre-mRNAs (AMA1, MER2, MER3) during meiosis in the yeast Saccharomyces cerevisiae. We demonstrate that enhancer recognition by Mer1p is separable from Mer1p splicing activation...