Gene Symbol: MDM38
Description: ribosome-binding protein MDM38
Alias: MKH1, ribosome-binding protein MDM38
Species: Saccharomyces cerevisiae S288c
Nowikovsky K, Froschauer E, Zsurka G, Samaj J, Reipert S, Kolisek M, et al
. The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem. 2004;279:30307-15 pubmed
..Thus, YOL027/LETM1 are the first genes shown to encode factors involved in both K+ homeostasis and organelle volume control...
Zotova L, Aleschko M, Sponder G, Baumgartner R, Reipert S, Prinz M, et al
. Novel components of an active mitochondrial K(+)/H(+) exchange. J Biol Chem. 2010;285:14399-414 pubmed publisher
..We have previously identified the yeast Mdm38 and its human homologue LETM1, the candidate gene for seizures in Wolf-Hirschhorn syndrome, as essential ..
Froschauer E, Nowikovsky K, Schweyen R. Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta. 2005;1711:41-8 pubmed
..Considering their newly identified function, we propose to refer to the yeast YOL027c gene and the human LETM1 gene as yMKH1 and hMKH1, respectively. ..
Bauerschmitt H, Mick D, Deckers M, Vollmer C, Funes S, Kehrein K, et al
. Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. Mol Biol Cell. 2010;21:1937-44 pubmed publisher
..b>Mdm38 is related to Letm1, a protein affected in Wolf-Hirschhorn syndrome patients...
Keil M, Bareth B, Woellhaf M, Peleh V, Prestele M, Rehling P, et al
. Oxa1-ribosome complexes coordinate the assembly of cytochrome C oxidase in mitochondria. J Biol Chem. 2012;287:34484-93 pubmed publisher
..This points to a role for Oxa1 in the spatial coordination of the ribosome with assembly factors that are critical for enzyme biogenesis. ..
Lupo D, Vollmer C, Deckers M, Mick D, Tews I, Sinning I, et al
. Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane. Traffic. 2011;12:1457-66 pubmed publisher
..b>Mdm38/Letm1 is a conserved membrane receptor for mitochondrial ribosomes and specifically involved in respiratory chain ..