Gene Symbol: MDM36
Species: Saccharomyces cerevisiae S288c
Dimmer K, Fritz S, Fuchs F, Messerschmitt M, Weinbach N, Neupert W, et al
. Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell. 2002;13:847-53 pubmed
..These data provide a comprehensive picture of the cellular processes and molecular components required for mitochondrial function and structure in a simple eukaryotic cell. ..
Hammermeister M, Schödel K, Westermann B. Mdm36 is a mitochondrial fission-promoting protein in Saccharomyces cerevisiae. Mol Biol Cell. 2010;21:2443-52 pubmed publisher
..We have identified Mdm36 as a mitochondria-associated protein required for efficient mitochondrial division...
Klecker T, Scholz D, Förtsch J, Westermann B. The yeast cell cortical protein Num1 integrates mitochondrial dynamics into cellular architecture. J Cell Sci. 2013;126:2924-30 pubmed publisher
..Expression of chimeric plasma membrane tethers rescued mitochondrial fission defects in ?num1 and ?mdm36 mutants...
Lackner L, Ping H, Graef M, Murley A, Nunnari J. Endoplasmic reticulum-associated mitochondria-cortex tether functions in the distribution and inheritance of mitochondria. Proc Natl Acad Sci U S A. 2013;110:E458-67 pubmed publisher
..Our data indicate that Num1, together with Mdm36, forms a physical tether that robustly anchors mitochondria to the cell cortex but plays no direct role in ..
Joshi A, Fei N, Greenberg M. Get1p and Get2p are required for maintenance of mitochondrial morphology and normal cardiolipin levels. FEMS Yeast Res. 2016;16: pubmed publisher
..The genetic interactions observed in this study identify novel physiological modifiers that are required for maintenance of CL levels and mitochondrial morphology. ..
Ping H, Kraft L, Chen W, Nilles A, Lackner L. Num1 anchors mitochondria to the plasma membrane via two domains with different lipid binding specificities. J Cell Biol. 2016;213:513-24 pubmed publisher
..Thus, mitochondrial anchoring is mediated by a protein that interacts directly with two different membranes through lipid-specific binding domains, suggesting a general mechanism for interorganelle tethering. ..