Gene Symbol: MDM12
Description: ERMES complex subunit MDM12
Alias: ERMES complex subunit MDM12
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Berger K, Sogo L, Yaffe M. Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast. J Cell Biol. 1997;136:545-53 pubmed
    Saccharomyces cerevisiae cells lacking the MDM12 gene product display temperature-sensitive growth and possess abnormally large, round mitochondria that are defective for inheritance by daughter buds...
  2. Meisinger C, Pfannschmidt S, Rissler M, Milenkovic D, Becker T, Stojanovski D, et al. The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J. 2007;26:2229-39 pubmed
    ..b>Mdm12/Mmm1 function after SAM(core) yet before splitting of the major pathway...
  3. Hermann G, Shaw J. Mitochondrial dynamics in yeast. Annu Rev Cell Dev Biol. 1998;14:265-303 pubmed
  4. Kornmann B, Currie E, Collins S, Schuldiner M, Nunnari J, Weissman J, et al. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science. 2009;325:477-81 pubmed publisher
    ..We identified the Mmm1/Mdm10/Mdm12/Mdm34 complex as a molecular tether between ER and mitochondria...
  5. Yamano K, Tanaka Yamano S, Endo T. Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40. J Biol Chem. 2010;285:41222-31 pubmed publisher
    ..These results collectively show that Tom7 recruits Mdm10, enhancing its association with the MMM1 complex, to regulate timing of the release of Tom40 from the TOB complex for subsequent assembly into the TOM40 complex. ..
  6. Stroud D, Oeljeklaus S, Wiese S, Bohnert M, Lewandrowski U, Sickmann A, et al. Composition and topology of the endoplasmic reticulum-mitochondria encounter structure. J Mol Biol. 2011;413:743-50 pubmed publisher
    ..ERMES proteins are known in yeast, the ER-anchored protein Mmm1 and three mitochondria-associated proteins, Mdm10, Mdm12 and Mdm34, with functions related to mitochondrial morphology and protein biogenesis...
  7. Boldogh I, Nowakowski D, Yang H, Chung H, Karmon S, Royes P, et al. A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery. Mol Biol Cell. 2003;14:4618-27 pubmed
    ..In contrast, deletion of MMM1 resulted in mislocalization of Mdm12p, and deletion of MDM12 caused mislocalization of Mmm1p...
  8. Yamano K, Tanaka Yamano S, Endo T. Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40. EMBO Rep. 2010;11:187-93 pubmed publisher
    ..These results show that Mdm10 regulates the timing of release of unassembled Tom40 from the TOB complex, to facilitate its coordinated assembly into the TOM40 complex. ..
  9. Kojima R, Kajiura S, Sesaki H, Endo T, Tamura Y. Identification of multi-copy suppressors for endoplasmic reticulum-mitochondria tethering proteins in Saccharomyces cerevisiae. FEBS Lett. 2016;590:3061-70 pubmed publisher
    ..We found that Ole1 partially relieves the growth defects of ERMES-lacking cells, thus uncovering a relationship between fatty acid metabolism and ERMES functions. ..

More Information


  1. Stroud D, Becker T, Qiu J, Stojanovski D, Pfannschmidt S, Wirth C, et al. Biogenesis of mitochondrial ?-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex. Mol Biol Cell. 2011;22:2823-33 pubmed publisher
    ..These results indicate the POTRA domain of Sam50 is not essential for recognition of ?-barrel precursors but functions in a subsequent step to promote the release of precursor proteins from the SAM complex. ..
  2. Belgareh Touzé N, Cavellini L, Cohen M. Ubiquitination of ERMES components by the E3 ligase Rsp5 is involved in mitophagy. Autophagy. 2017;13:114-132 pubmed publisher
    ..However, it remains unclear how these different functions are regulated. We show here that Mdm34 and Mdm12, 2 components of ERMES, are ubiquitinated by the E3 ligase Rsp5...
  3. Jeong H, Park J, Lee C. Crystal structure of Mdm12 reveals the architecture and dynamic organization of the ERMES complex. EMBO Rep. 2016;17:1857-1871 pubmed
    ..The ERMES complex is composed of Mdm12, Mmm1, and Mdm34, which have a SMP domain in common, and Mdm10. Here, we report the crystal structure of S...
  4. Kojima R, Endo T, Tamura Y. A phospholipid transfer function of ER-mitochondria encounter structure revealed in vitro. Sci Rep. 2016;6:30777 pubmed publisher
    ..This in vitro assay system thus offers a powerful tool to analyze the non-vesicular phospholipid transport between the ER and mitochondria. ..
  5. Tan T, Ozbalci C, Br gger B, Rapaport D, Dimmer K. Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis. J Cell Sci. 2013;126:3563-74 pubmed publisher
    ..Collectively, this work identifies two novel proteins that play a role in mitochondrial lipid homeostasis and describes a role of Mdm10 in ergosterol trafficking...
  6. Voss C, Lahiri S, Young B, Loewen C, Prinz W. ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae. J Cell Sci. 2012;125:4791-9 pubmed publisher
  7. García Rodríguez L, Gay A, Pon L. Puf3p, a Pumilio family RNA binding protein, localizes to mitochondria and regulates mitochondrial biogenesis and motility in budding yeast. J Cell Biol. 2007;176:197-207 pubmed
    ..Thus, Puf3p is a mitochondrial protein that contributes to the biogenesis and motility of the organelle. ..
  8. Boldogh I, Ramcharan S, Yang H, Pon L. A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division. Mol Biol Cell. 2004;15:3994-4002 pubmed
    ..Finally, destabilization of actin cables and the resulting delocalization of Myo2p from the bud tip had no significant effect on the accumulation of mitochondria in the bud tip. ..
  9. Nguyen T, Lewandowska A, Choi J, Markgraf D, Junker M, Bilgin M, et al. Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic. 2012;13:880-90 pubmed publisher
    ..Finally, we show that ERMES complexes are long-lived, and do not depend on the presence of Gem1. Our findings suggest that the ERMES complex may have primarily a structural role in maintaining mitochondrial morphology. ..
  10. Tamura Y, Onguka O, Hobbs A, Jensen R, Iijima M, Claypool S, et al. Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking. J Biol Chem. 2012;287:15205-18 pubmed publisher
    ..Our results suggest that Ups proteins and Mdm31p play important roles in phospholipid biosynthesis in mitochondria. Ups proteins may function in phospholipid trafficking between the outer and inner mitochondrial membranes. ..
  11. Dimmer K, Jakobs S, Vogel F, Altmann K, Westermann B. Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast. J Cell Biol. 2005;168:103-15 pubmed of the MDM31 and MDM32 genes is synthetically lethal with deletion of either one of the MMM1, MMM2, MDM10, and MDM12 genes, which encode outer membrane proteins involved in mitochondrial morphogenesis and mtDNA inheritance...
  12. Berger K, Yaffe M. Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol. 1998;18:4043-52 pubmed
    ..These results provide the first evidence of a role for prohibitin in mitochondrial inheritance and in the regulation of mitochondrial morphology. ..