Gene Symbol: MDM1
Species: Saccharomyces cerevisiae S288c
McConnell S, Stewart L, Talin A, Yaffe M. Temperature-sensitive yeast mutants defective in mitochondrial inheritance. J Cell Biol. 1990;111:967-76 pubmed
..Two of these mutants contain single, recessive, nuclear mutations, mdm1 and mdm2, that cause temperature-sensitive growth and aberrant mitochondrial distribution at the nonpermissive ..
McConnell S, Yaffe M. Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein. J Cell Biol. 1992;118:385-95 pubmed
..The MDM1 gene was cloned by complementation, and its sequence revealed an open reading frame encoding a potential protein ..
Fisk H, Yaffe M. Mutational analysis of Mdm1p function in nuclear and mitochondrial inheritance. J Cell Biol. 1997;138:485-94 pubmed
Nuclear and mitochondrial transmission to daughter buds of Saccharomyces cerevisiae depends on Mdm1p, an intermediate filament-like protein localized to numerous punctate structures distributed throughout the yeast cell cytoplasm...
Henne W, Zhu L, Balogi Z, Stefan C, Pleiss J, Emr S. Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein. J Cell Biol. 2015;210:541-51 pubmed publisher
..Screening implicated Phox (PX) domain-containing protein Mdm1 in endomembrane dynamics...
Hermann G, Shaw J. Mitochondrial dynamics in yeast. Annu Rev Cell Dev Biol. 1998;14:265-303 pubmed
Chasse S, Flanary P, Parnell S, Hao N, Cha J, Siderovski D, et al
. Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae. Eukaryot Cell. 2006;5:330-46 pubmed
..In the yeast Saccharomyces cerevisiae there are four RGS-homologous proteins (Sst2, Rgs2, Rax1, and Mdm1) and two Galpha proteins (Gpa1 and Gpa2)...
Yu J, Lemmon M. All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. J Biol Chem. 2001;276:44179-84 pubmed
..Our results establish that PtdIns-3-P, and not other phosphoinositides, is the target of all PX domains in S. cerevisiae and suggest a role for PX domains in assembly of multiprotein complexes at specific membrane surfaces. ..
Fisk H, Yaffe M. A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae. J Cell Biol. 1999;145:1199-208 pubmed
The smm1 mutation suppresses defects in mitochondrial distribution and morphology caused by the mdm1-252 mutation in the yeast Saccharomyces cerevisiae...