Gene Symbol: MDL1
Description: ATP-binding cassette permease MDL1
Alias: ATP-binding cassette permease MDL1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Young L, Leonhard K, Tatsuta T, Trowsdale J, Langer T. Role of the ABC transporter Mdl1 in peptide export from mitochondria. Science. 2001;291:2135-8 pubmed
    ..Here, the ABC protein Mdl1 was identified as an intracellular peptide transporter localized in the inner membrane of yeast mitochondria...
  2. Kawabata K, Mitsui K, Uno T, Tamura K, Tsurugi K. Protein interactions of Gts1p of Saccharomyces cerevisiae throughout a region similar to a cytoplasmic portion of some ATP-binding cassette transporters. Eur J Biochem. 1999;259:112-9 pubmed
    ..These results suggest that Gts1p interacts with some ABC transporters through the binding site overlapping that of homodimerization and modulates their activity...
  3. van der Does C, Presenti C, Schulze K, Dinkelaker S, Tampe R. Kinetics of the ATP hydrolysis cycle of the nucleotide-binding domain of Mdl1 studied by a novel site-specific labeling technique. J Biol Chem. 2006;281:5694-701 pubmed
    ..model for the ATP hydrolysis cycle of the nucleotide-binding domain (NBD) of the mitochondrial ABC transporter Mdl1 (Janas, E., Hofacker, M., Chen, M., Gompf, S., van der Does, C., and Tampé, R. (2003) J. Biol. Chem...
  4. Hofacker M, Gompf S, Zutz A, Presenti C, Haase W, van der Does C, et al. Structural and functional fingerprint of the mitochondrial ATP-binding cassette transporter Mdl1 from Saccharomyces cerevisiae. J Biol Chem. 2007;282:3951-61 pubmed
    The ATP-binding cassette half-transporter Mdl1 from Saccharomyces cerevisiae has been proposed to be involved in the quality control of misassembled respiratory chain complexes by exporting degradation products generated by the m-AAA ..
  5. Gompf S, Zutz A, Hofacker M, Haase W, van der Does C, Tampe R. Switching of the homooligomeric ATP-binding cassette transport complex MDL1 from post-translational mitochondrial import to endoplasmic reticulum insertion. FEBS J. 2007;274:5298-310 pubmed
    The ATP-binding cassette transporter MDL1 of Saccharomyces cerevisiae has been implicated in mitochondrial quality control, exporting degradation products of misassembled respiratory chain complexes...
  6. Stames E, O Toole J. Mitochondrial aminopeptidase deletion increases chronological lifespan and oxidative stress resistance while decreasing respiratory metabolism in S. cerevisiae. PLoS ONE. 2013;8:e77234 pubmed publisher
  7. Park K, Jung S, Kim H, Kim H. Mode of membrane insertion of individual transmembrane segments in Mdl1 and Mdl2, multi-spanning mitochondrial ABC transporters. FEBS Lett. 2014;588:3445-53 pubmed publisher
    ..These data imply that TIM23-mediated membrane insertion highly depends on the TM domain sequence context. ..
  8. Melin J, Kilisch M, Neumann P, Lytovchenko O, Gomkale R, Schendzielorz A, et al. A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondria. Biochim Biophys Acta. 2015;1853:1850-9 pubmed publisher
    ..binding affinity of Tom70 ten-fold and selectively impairs import of the presequence-containing precursor Mdl1 but not the ADP/ATP carrier (AAC)...
  9. Janas E, Hofacker M, Chen M, Gompf S, van der Does C, Tampe R. The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p. J Biol Chem. 2003;278:26862-9 pubmed
    ..Based on these data, we propose a processive-clamp model for the catalytic cycle in which association and dissociation of the NBDs depends on the status of bound nucleotides...

More Information


  1. Chloupkova M, LeBard L, Koeller D. MDL1 is a high copy suppressor of ATM1: evidence for a role in resistance to oxidative stress. J Mol Biol. 2003;331:155-65 pubmed
    ..One of the genes we identified was MDL1, which like ATM1, encodes a mitochondrial inner membrane ABC transporter...