Gene Symbol: MDH1
Description: malate dehydrogenase MDH1
Alias: malate dehydrogenase MDH1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Easlon E, Tsang F, Skinner C, Wang C, Lin S. The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. Genes Dev. 2008;22:931-44 pubmed publisher
    ..Here we show that the mitochondrial components of the malate-aspartate NADH shuttle (Mdh1 [malate dehydrogenase] and Aat1 [aspartate amino transferase]) and the glycerol-3-phosphate shuttle (Gut2, glycerol-..
  2. McAlister Henn L, Thompson L. Isolation and expression of the gene encoding yeast mitochondrial malate dehydrogenase. J Bacteriol. 1987;169:5157-66 pubmed
    ..Disruption of the chromosomal malate dehydrogenase gene in haploid S. cerevisiae produces mutants unable to grow on acetate and impaired in growth on glycerol plus lactate as carbon sources. ..
  3. Scherrer T, Mittal N, Janga S, Gerber A. A screen for RNA-binding proteins in yeast indicates dual functions for many enzymes. PLoS ONE. 2010;5:e15499 pubmed publisher
    ..Our results suggest that many proteins may associate with mRNAs and possibly control their fates, providing dense connections between different layers of cellular regulation. ..
  4. Steffan J, McAlister Henn L. Isolation and characterization of the yeast gene encoding the MDH3 isozyme of malate dehydrogenase. J Biol Chem. 1992;267:24708-15 pubmed
    ..cerevisiae was purified from a haploid strain containing disruptions in genomic loci encoding the mitochondrial MDH1 and nonmitochondrial MDH2 isozymes...
  5. Vélot C, Srere P. Reversible transdominant inhibition of a metabolic pathway. In vivo evidence of interaction between two sequential tricarboxylic acid cycle enzymes in yeast. J Biol Chem. 2000;275:12926-33 pubmed
  6. Vélot C, Lebreton S, Morgunov I, Usher K, Srere P. Metabolic effects of mislocalized mitochondrial and peroxisomal citrate synthases in yeast Saccharomyces cerevisiae. Biochemistry. 1999;38:16195-204 pubmed
    ..Altogether, these data indicate that metabolic functions may require structural as well as catalytic roles for the enzymes. ..
  7. Masciadri B, Areces L, Carpinelli P, Foiani M, Draetta G, Fiore F. Characterization of the BUD31 gene of Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2004;320:1342-50 pubmed
    ..We propose that the observed phenotypes for bud31-null strain could be the result of defective splicing and indicate a first functional role for Bud3lp and its homologs. ..
  8. Braun B, Pfirrmann T, Menssen R, Hofmann K, Scheel H, Wolf D. Gid9, a second RING finger protein contributes to the ubiquitin ligase activity of the Gid complex required for catabolite degradation. FEBS Lett. 2011;585:3856-61 pubmed publisher
    ..This subunit binds to Gid2/Rmd5. A mutation in the degenerated RING finger of Gid9/Fyv10 abolishes polyubiquitylation and degradation of three enzymes specific for gluconeogenesis. ..
  9. Steffan J, McAlister Henn L. Structural and functional effects of mutations altering the subunit interface of mitochondrial malate dehydrogenase. Arch Biochem Biophys. 1991;287:276-82 pubmed
    ..enzymes containing Asn-43 and Leu-46 substitutions using in vitro mutagenesis of the Saccharomyces cerevisiae gene (MDH1) encoding mitochondrial malate dehydrogenase...

More Information


  1. Dubaquie Y, Looser R, Funfschilling U, Jeno P, Rospert S. Identification of in vivo substrates of the yeast mitochondrial chaperonins reveals overlapping but non-identical requirement for hsp60 and hsp10. EMBO J. 1998;17:5868-76 pubmed
    ..We suggest that homologous substrate proteins have differential chaperonin requirements, indicating that hsp60 and hsp10 do not always act as a single functional unit in vivo. ..
  2. Skowronek E, Grzechnik P, Späth B, Marchfelder A, Kufel J. tRNA 3' processing in yeast involves tRNase Z, Rex1, and Rrp6. RNA. 2014;20:115-30 pubmed publisher
    ..In addition to its function in the nucleus, Trz1 processes the 3' ends of mitochondrial tRNAs, contributing to the general RNA metabolism in this organelle. ..
  3. Przybyla Zawislak B, Gadde D, Ducharme K, McCammon M. Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes. Genetics. 1999;152:153-66 pubmed
    ..These results provide genetic evidence that NAD-IDH plays a unique role in TCA cycle function. ..
  4. Brandina I, Graham J, Lemaitre Guillier C, Entelis N, Krasheninnikov I, Sweetlove L, et al. Enolase takes part in a macromolecular complex associated to mitochondria in yeast. Biochim Biophys Acta. 2006;1757:1217-28 pubmed
    ..This suggests an unsuspected novel function for this complex in tRNA mitochondrial import. ..
  5. Grandier Vazeille X, Bathany K, Chaignepain S, Camougrand N, Manon S, Schmitter J. Yeast mitochondrial dehydrogenases are associated in a supramolecular complex. Biochemistry. 2001;40:9758-69 pubmed
    ..The association of these proteins is discussed in terms of NADH-channeling. ..
  6. Minard K, McAlister Henn L. Isolation, nucleotide sequence analysis, and disruption of the MDH2 gene from Saccharomyces cerevisiae: evidence for three isozymes of yeast malate dehydrogenase. Mol Cell Biol. 1991;11:370-80 pubmed
    ..Disruption of the MDH2 gene in a haploid strain also containing a disruption in the chromosomal MDH1 gene encoding the mitochondrial isozyme produced a strain unable to grow with acetate but capable of growth on rich ..