Gene Symbol: MBA1
Species: Saccharomyces cerevisiae S288c
Rep M, Nooy J, Guelin E, Grivell L. Three genes for mitochondrial proteins suppress null-mutations in both Afg3 and Rca1 when over-expressed. Curr Genet. 1996;30:206-11 pubmed
..encodes a putative mitochondrial inner membrane protein involved in the biogenesis of the respiratory chain; and MBA1 encodes a mitochondrial protein required for optimal respiratory growth...
Preuss M, Leonhard K, Hell K, Stuart R, Neupert W, Herrmann J. Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae. J Cell Biol. 2001;153:1085-96 pubmed
..The inner membrane protein Oxa1 plays an important role in this process. We identified Mba1 as a second mitochondrial component that is required for efficient protein insertion...
Ott M, Prestele M, Bauerschmitt H, Funes S, Bonnefoy N, Herrmann J. Mba1, a membrane-associated ribosome receptor in mitochondria. EMBO J. 2006;25:1603-10 pubmed
..Here, we show that the inner membrane protein Mba1 binds to the large subunit of mitochondrial ribosomes...
Gruschke S, Gröne K, Heublein M, Hölz S, Israel L, Imhof A, et al
. Proteins at the polypeptide tunnel exit of the yeast mitochondrial ribosome. J Biol Chem. 2010;285:19022-8 pubmed publisher
..This network includes Mba1, the membrane-bound ribosome receptor of the inner membrane, as well as Mrpl3, Mrpl13, and Mrpl27, which constitute ..
Bauerschmitt H, Mick D, Deckers M, Vollmer C, Funes S, Kehrein K, et al
. Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. Mol Biol Cell. 2010;21:1937-44 pubmed publisher
..Mdm38 is related to Letm1, a protein affected in Wolf-Hirschhorn syndrome patients. Like Mba1 and Oxa1, Mdm38 is an inner membrane protein that interacts with ribosomes and is involved in respiratory chain ..
Keil M, Bareth B, Woellhaf M, Peleh V, Prestele M, Rehling P, et al
. Oxa1-ribosome complexes coordinate the assembly of cytochrome C oxidase in mitochondria. J Biol Chem. 2012;287:34484-93 pubmed publisher
..In the absence of the ribosome receptor Mba1, these linkers caused a length-dependent decrease in mitochondrial respiratory activity caused by diminished levels ..
Funes S, Westerburg H, Jaimes Miranda F, Woellhaf M, Aguilar Lopez J, Jansen L, et al
. Partial suppression of Oxa1 mutants by mitochondria-targeted signal recognition particle provides insights into the evolution of the cotranslational insertion systems. FEBS J. 2013;280:904-15 pubmed publisher
..Accordingly, deletion of ribosome-binding sites on the Oxa1 insertase and the Mba1 ribosome receptor in yeast leads to severe defects in cotranslational protein insertion and results in respiration-..