Gene Symbol: MAS1
Alias: MIF1, Mas1p
Species: Saccharomyces cerevisiae S288c
Yang M, Geli V, Oppliger W, Suda K, James P, Schatz G. The MAS-encoded processing protease of yeast mitochondria. Interaction of the purified enzyme with signal peptides and a purified precursor protein. J Biol Chem. 1991;266:6416-23 pubmed
..The enzyme consists of two nonidentical subunits that are encoded by the nuclear genes MAS1 and MAS2...
West A, Clark D, Martin J, Neupert W, Hartl F, Horwich A. Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein. J Biol Chem. 1992;267:24625-33 pubmed
..We suggest that SMF1 and SMF2 are mitochondrial membrane proteins that influence PEP-dependent protein import, possibly at the step of protein translocation. ..
Yang M, Jensen R, Yaffe M, Oppliger W, Schatz G. Import of proteins into yeast mitochondria: the purified matrix processing protease contains two subunits which are encoded by the nuclear MAS1 and MAS2 genes. EMBO J. 1988;7:3857-62 pubmed
..The smaller subunit had been identified as the product of the nuclear MAS1 gene (Witte et al., 1988). The larger subunit is now identified as the product of the nuclear MAS2 gene.
Supek F, Supekova L, Nelson H, Nelson N. A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria. Proc Natl Acad Sci U S A. 1996;93:5105-10 pubmed
..This also suggests that in vivo Mas1p is a manganese-dependent peptidase. The yeast Smf1p resembles a protein from Drosophila and mammalian macrophages...
Vögtle F, Wortelkamp S, Zahedi R, Becker D, Leidhold C, Gevaert K, et al
. Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell. 2009;139:428-39 pubmed publisher
..Our results suggest that Icp55 is critical for stabilization of the mitochondrial proteome and illustrate how the N-proteome can serve as rich source for a systematic analysis of mitochondrial protein targeting, cleavage and turnover. ..
Taskin A, Kucukkose C, Burger N, Mossmann D, Meisinger C, Vögtle F. The novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing. Mol Biol Cell. 2017;28:997-1002 pubmed publisher
..Ste23 and Cym1 tightly cooperate to ensure the correct functioning of the essential presequence processing machinery. ..