Gene Symbol: MAL11
Description: alpha-glucoside permease
Alias: AGT1, alpha-glucoside permease
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Cheng Q, Michels C. MAL11 and MAL61 encode the inducible high-affinity maltose transporter of Saccharomyces cerevisiae. J Bacteriol. 1991;173:1817-20 pubmed
    ..The high-affinity maltose transporter is maltose inducible and is encoded by the MAL11 (and/or MAL61) gene of the MAL1 (and/or MAL6) locus...
  2. Tapia H, Young L, Fox D, Bertozzi C, Koshland D. Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2015;112:6122-7 pubmed publisher
    ..The effectiveness and sufficiency of trehalose as an antagonizer of desiccation-induced damage in yeast emphasizes its potential to confer desiccation tolerance to otherwise sensitive organisms. ..
  3. Gadura N, Michels C. Sequences in the N-terminal cytoplasmic domain of Saccharomyces cerevisiae maltose permease are required for vacuolar degradation but not glucose-induced internalization. Curr Genet. 2006;50:101-14 pubmed
  4. Garre E, Matallana E. The three trehalases Nth1p, Nth2p and Ath1p participate in the mobilization of intracellular trehalose required for recovery from saline stress in Saccharomyces cerevisiae. Microbiology. 2009;155:3092-9 pubmed publisher
  5. Han E, Cotty F, Sottas C, Jiang H, Michels C. Characterization of AGT1 encoding a general alpha-glucoside transporter from Saccharomyces. Mol Microbiol. 1995;17:1093-107 pubmed
    Molecular genetic analysis is used to characterize the AGT1 gene encoding an alpha-glucoside transporter...
  6. Brown C, Murray A, Verstrepen K. Rapid expansion and functional divergence of subtelomeric gene families in yeasts. Curr Biol. 2010;20:895-903 pubmed publisher
  7. Needleman R, Kaback D, Dubin R, Perkins E, Rosenberg N, Sutherland K, et al. MAL6 of Saccharomyces: a complex genetic locus containing three genes required for maltose fermentation. Proc Natl Acad Sci U S A. 1984;81:2811-5 pubmed
    ..This clustered arrangement of a regulatory gene adjacent to the sequences it controls has not previously been described in eukaryotes and is reminiscent of bacterial operons except that the messenger RNA molecules are not polycistronic. ..
  8. Alves S, Herberts R, Hollatz C, Trichez D, Miletti L, de Araujo P, et al. Molecular analysis of maltotriose active transport and fermentation by Saccharomyces cerevisiae reveals a determinant role for the AGT1 permease. Appl Environ Microbiol. 2008;74:1494-501 pubmed publisher
    ..been conflicting reports on whether all the known alpha-glucoside transporters in Saccharomyces cerevisiae (MALx1, AGT1, and MPH2 and MPH3 transporters) allow efficient maltotriose utilization by yeast cells...
  9. Teste M, Francois J, Parrou J. Characterization of a new multigene family encoding isomaltases in the yeast Saccharomyces cerevisiae, the IMA family. J Biol Chem. 2010;285:26815-24 pubmed publisher
    ..revealed that IMA1/YGR287c encodes the major isomaltase and that growth on isomaltose required the presence of AGT1, which encodes an alpha-glucoside transporter...

More Information


  1. Stambuk B, de Araujo P. Kinetics of active alpha-glucoside transport in Saccharomyces cerevisiae. FEMS Yeast Res. 2001;1:73-8 pubmed
    ..On the other hand, the alpha-glucoside permease encoded by the AGT1 gene had a high affinity (K(m) approximately 7 mM) for trehalose, a low affinity (K(m) approximately 18 mM) for ..
  2. Gibney P, Schieler A, Chen J, Rabinowitz J, Botstein D. Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter. Proc Natl Acad Sci U S A. 2015;112:6116-21 pubmed publisher
    ..Tapia H, et al. (2015) Proc Natl Acad Sci USA, 10.1073/pnas.1506415112] demonstrate a direct role for trehalose in protecting cells against desiccation). ..