LYS5

Summary

Gene Symbol: LYS5
Description: holo-[acyl-carrier-protein] synthase
Alias: holo-[acyl-carrier-protein] synthase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Bhattacharjee J. alpha-Aminoadipate pathway for the biosynthesis of lysine in lower eukaryotes. Crit Rev Microbiol. 1985;12:131-51 pubmed
    ..for ten of the lysine loci which include two unlinked gene functions required for each of AA reductase (LYS2 and LYS5) and Saccharopine reductase (LYS9 and LYS14)...
  2. Praphanphoj V, Sacksteder K, Gould S, Thomas G, Geraghty M. Identification of the alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene. Mol Genet Metab. 2001;72:336-42 pubmed
    ..LYS2 encodes the alpha-aminoadipate reductase activity, while LYS5 encodes a phosphopantetheinyl transferase activity that is required to activate Lys2p...
  3. Johansson P, Mulinacci B, Koestler C, Vollrath R, Oesterhelt D, Grininger M. Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase. Structure. 2009;17:1063-74 pubmed publisher
  4. Ehmann D, Gehring A, Walsh C. Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5. Biochemistry. 1999;38:6171-7 pubmed
    ..of alpha-aminoadipate at C6 to the semialdehyde, requires two gene products in Saccharomyces cerevisiae, Lys2 and Lys5. Here, we show that the 31-kDa Lys5 is a specific posttranslational modification catalyst, using coenzyme A (CoASH) ..