Gene Symbol: LYS20
Description: homocitrate synthase LYS20
Alias: homocitrate synthase LYS20
Species: Saccharomyces cerevisiae S288c
Quezada H, Aranda C, DeLuna A, Hernández H, Calcagno M, Marin Hernandez A, et al
. Specialization of the paralogue LYS21 determines lysine biosynthesis under respiratory metabolism in Saccharomyces cerevisiae. Microbiology. 2008;154:1656-67 pubmed publisher
..the first committed step of the lysine biosynthetic pathway is catalysed by two homocitrate synthases encoded by LYS20 and LYS21...
Chang C, Clarke A, Pillus L. Suppression analysis of esa1 mutants in Saccharomyces cerevisiae links NAB3 to transcriptional silencing and nucleolar functions. G3 (Bethesda). 2012;2:1223-32 pubmed publisher
..In this study, four genes (LYS20, LEU2, VAP1, and NAB3) were identified in a genetic screen as high-copy suppressors of the conditional temperature-..
Chen S, Brockenbrough J, Dove J, Aris J. Homocitrate synthase is located in the nucleus in the yeast Saccharomyces cerevisiae. J Biol Chem. 1997;272:10839-46 pubmed
..five independent full-length clones of two open reading frames from chromosome IV, corresponding to YDL182w (LYS20) and YDL131w in the Saccharomyces genome data base...
Scott E, Pillus L. Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage. Genes Dev. 2010;24:1903-13 pubmed publisher
..We demonstrate that HCS encoded by LYS20 in yeast is linked to the key process of DNA damage repair through the essential MYST family histone ..
Ramos F, Verhasselt P, Feller A, Peeters P, Wach A, Dubois E, et al
. Identification of a gene encoding a homocitrate synthase isoenzyme of Saccharomyces cerevisiae. Yeast. 1996;12:1315-20 pubmed
..Disruption and overexpression of ORF D1298 demonstrate that this gene, named LYS20, encodes a homocitrate synthase...
Andi B, West A, Cook P. Stabilization and characterization of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. Arch Biochem Biophys. 2004;421:243-54 pubmed
..Fluorescence quenching studies with KI, CsCl, and acrylamide suggest that the microenvironment around the single tryptophan residue of the enzyme has some positive charge. ..
Torres Machorro A, Aris J, Pillus L. A moonlighting metabolic protein influences repair at DNA double-stranded breaks. Nucleic Acids Res. 2015;43:1646-58 pubmed publisher
..In this work we characterize a new, chromatin-based function of Lys20, a moonlighting protein that is well known for its role in metabolism...