Gene Symbol: LYS14
Species: Saccharomyces cerevisiae S288c
Feller A, Dubois E, Ramos F, Pierard A. Repression of the genes for lysine biosynthesis in Saccharomyces cerevisiae is caused by limitation of Lys14-dependent transcriptional activation. Mol Cell Biol. 1994;14:6411-8 pubmed
The product of the LYS14 gene of Saccharomyces cerevisiae activates the transcription of at least four genes involved in lysine biosynthesis...
Borell C, Urrestarazu L, Bhattacharjee J. Two unlinked lysine genes (LYS9 and LYS14) are required for the synthesis of saccharopine reductase in Saccharomyces cerevisiae. J Bacteriol. 1984;159:429-32 pubmed
..Complementation studies placed these three mutations into a single, new complementation group, lys14. Tetrad analysis from appropriate crosses provided evidence that the lys14 locus represented a single nuclear gene ..
el Alami M, Feller A, Pierard A, Dubois E. Characterisation of a tripartite nuclear localisation sequence in the regulatory protein Lys14 of Saccharomyces cerevisiae. Curr Genet. 2000;38:78-86 pubmed
..Studies with a fused Lys14-green fluorescent protein reveal that Lys14p is localised to the nucleus, even under growth conditions leading to the absence of LYS gene expression...
El Alami M, Feller A, Piérard A, Dubois E. The proper folding of a long C-terminal segment of the yeast Lys14p regulator is required for activation of LYS genes in response to the metabolic effector. Mol Microbiol. 2002;43:1629-39 pubmed
Transcription of lysine genes in Saccharomyces cerevisiae is dependent on Lys14p and on alpha-aminoadipate semialdehyde (alphaAASA), an intermediate of the pathway...
Ramos F, Dubois E, Pierard A. Control of enzyme synthesis in the lysine biosynthetic pathway of Saccharomyces cerevisiae. Evidence for a regulatory role of gene LYS14. Eur J Biochem. 1988;171:171-6 pubmed
..of Saccharomyces cerevisiae were found to respond to an induction mechanism mediated by the product of gene LYS14 in the presence of 2-aminoadipate semialdehyde, an intermediate of this pathway...
Becker B, Feller A, el Alami M, Dubois E, Pierard A. A nonameric core sequence is required upstream of the LYS genes of Saccharomyces cerevisiae for Lys14p-mediated activation and apparent repression by lysine. Mol Microbiol. 1998;29:151-63 pubmed
..Further evidence that this element is the target of Lys14p was provided by the demonstration that Lys14p binds to UASLYS in vitro...