LTV1

Summary

Gene Symbol: LTV1
Description: Ltv1p
Alias: YKL2, Ltv1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Schäfer T, Strauss D, Petfalski E, Tollervey D, Hurt E. The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes. EMBO J. 2003;22:1370-80 pubmed
    ..Our data provide an initial biochemical map of the pre-40S ribosomal subunit on its path from the nucleolus to the cytoplasm. This pathway involves fewer changes in composition than seen during 60S biogenesis. ..
  2. Neuber A, Franke J, Wittstruck A, Schlenstedt G, Sommer T, Stade K. Nuclear export receptor Xpo1/Crm1 is physically and functionally linked to the spindle pole body in budding yeast. Mol Cell Biol. 2008;28:5348-58 pubmed publisher
    ..In addition, we find a subpopulation of Xpo1 localized at the SPB. Based on these data, we propose a functional link between Xpo1 and the SPB and discuss a role for this exportin in spindle biogenesis in budding yeast. ..
  3. Merl J, Jakob S, Ridinger K, Hierlmeier T, Deutzmann R, Milkereit P, et al. Analysis of ribosome biogenesis factor-modules in yeast cells depleted from pre-ribosomes. Nucleic Acids Res. 2010;38:3068-80 pubmed publisher
    ..The data presented strengthen the idea that assembly of eukaryotic pre-ribosomal particles can result from transient association of distinct building blocks. ..
  4. Faza M, Chang Y, Occhipinti L, Kemmler S, Panse V. Role of Mex67-Mtr2 in the nuclear export of 40S pre-ribosomes. PLoS Genet. 2012;8:e1002915 pubmed publisher
    ..Mex67-Mtr2 could engage a regulatory crosstalk among the three major export pathways for optimal cellular growth and proliferation. ..
  5. Leger Silvestre I, Milkereit P, Ferreira Cerca S, Saveanu C, Rousselle J, Choesmel V, et al. The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast. EMBO J. 2004;23:2336-47 pubmed
    ..We conclude that, during the final maturation steps in the nucleus, incorporation of the ribosomal protein Rps15p is specifically required to render the pre-40S particles competent for translocation to the cytoplasm. ..
  6. Schäfer T, Maco B, Petfalski E, Tollervey D, Bottcher B, Aebi U, et al. Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit. Nature. 2006;441:651-5 pubmed
    ..In vivo depletion of Hrr25 inhibits growth and leads to the accumulation of immature 40S subunits that contain unstably bound Rps3. We conclude that the kinase activity of Hrr25 regulates the maturation of 40S ribosomal subunits. ..
  7. Seiser R, Sundberg A, Wollam B, Zobel Thropp P, Baldwin K, Spector M, et al. Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae. Genetics. 2006;174:679-91 pubmed
    ..b>Ltv1 is a nonessential, nonribosomal protein that is required for 40S subunit biogenesis in yeast...
  8. Sarkar A, Pech M, Thoms M, Beckmann R, Hurt E. Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit. Nat Struct Mol Biol. 2016;23:1074-1082 pubmed publisher
    ..Thus, a spatiotemporal mark on the ribosomal stalk controls the recruitment of an RNA-export receptor to the nascent 60S subunit. ..
  9. Mitterer V, Murat G, Réty S, Blaud M, Delbos L, Stanborough T, et al. Sequential domain assembly of ribosomal protein S3 drives 40S subunit maturation. Nat Commun. 2016;7:10336 pubmed publisher
    ..Yar1 is replaced by the assembly factor Ltv1, thereby fixing the S3 N-domain in the rotated orientation and preventing its 40S association...

More Information

Publications17

  1. Peters T, Miller A, Tourette C, Agren H, Hubbard A, Hughes R. Genomic Analysis of ATP Efflux in Saccharomyces cerevisiae. G3 (Bethesda). 2015;6:161-70 pubmed publisher
    ..These results will facilitate analysis of ATP efflux mechanisms in higher eukaryotes. ..
  2. Fischer U, Schäuble N, Schütz S, Altvater M, Chang Y, Faza M, et al. A non-canonical mechanism for Crm1-export cargo complex assembly. elife. 2015;4: pubmed publisher
    ..This mechanism could represent one solution to the paradox of weak binding events underlying rapid Crm1-mediated export. ..
  3. Moriggi G, Nieto B, Dosil M. Rrp12 and the Exportin Crm1 participate in late assembly events in the nucleolus during 40S ribosomal subunit biogenesis. PLoS Genet. 2014;10:e1004836 pubmed publisher
  4. Campbell M, Karbstein K. Protein-protein interactions within late pre-40S ribosomes. PLoS ONE. 2011;6:e16194 pubmed publisher
    ..Our data show that these factors form two modules: one comprising Enp1 and the export adaptor Ltv1 near the beak structure, and the second comprising the kinase Rio2, the nuclease Nob1, and a regulatory RNA binding ..
  5. Merwin J, Bogar L, Poggi S, Fitch R, Johnson A, Lycan D. Genetic analysis of the ribosome biogenesis factor Ltv1 of Saccharomyces cerevisiae. Genetics. 2014;198:1071-85 pubmed publisher
    Ribosome biogenesis has been studied extensively in the yeast Saccharomyces cerevisiae. Yeast Ltv1 is a conserved 40S-associated biogenesis factor that has been proposed to function in small subunit nuclear export...
  6. Schütz S, Fischer U, Altvater M, Nerurkar P, Peña C, Gerber M, et al. A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly. elife. 2014;3:e03473 pubmed publisher
    ..We anticipate similar carriers-termed here escortins-to securely connect the nuclear import machinery with pathways that deposit r-proteins onto developing pre-ribosomal particles. ..
  7. Gao M, Kaiser C. A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat Cell Biol. 2006;8:657-67 pubmed
    ..The complex contains two small GTPases (Gtr1p and Gtr2p) and three other proteins (Ybr077c, Ykr007w and Ltv1p) that are located in the late endosomal membrane...
  8. Loar J, Seiser R, Sundberg A, Sagerson H, Ilias N, Zobel Thropp P, et al. Genetic and biochemical interactions among Yar1, Ltv1 and Rps3 define novel links between environmental stress and ribosome biogenesis in Saccharomyces cerevisiae. Genetics. 2004;168:1877-89 pubmed
    ..In this study we show that two nonessential stress-responsive genes, YAR1 and LTV1, function in 40S subunit production...