Gene Symbol: LSP1
Description: lipid-binding protein LSP1
Alias: lipid-binding protein LSP1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Zhang X, Lester R, Dickson R. Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p. J Biol Chem. 2004;279:22030-8 pubmed
    ..Homologs of Pil1p and Lsp1p are widespread in nature, and our results suggest that they may be negative regulators of PDK-like protein kinases and their downstream cellular pathways that control cell growth and survival. ..
  2. Karotki L, Huiskonen J, Stefan C, Ziółkowska N, Roth R, Surma M, et al. Eisosome proteins assemble into a membrane scaffold. J Cell Biol. 2011;195:889-902 pubmed publisher
    ..that are primarily composed of many subunits of two Bin-Amphiphysin-Rvs domain-containing proteins, Pil1 and Lsp1. In this paper, we show that these proteins self-assemble into higher-order structures and bind preferentially to ..
  3. Mascaraque V, Hernaez M, Jimenez Sanchez M, Hansen R, Gil C, Martín H, et al. Phosphoproteomic analysis of protein kinase C signaling in Saccharomyces cerevisiae reveals Slt2 mitogen-activated protein kinase (MAPK)-dependent phosphorylation of eisosome core components. Mol Cell Proteomics. 2013;12:557-74 pubmed publisher
    ..We show here that Pkc1-induced phosphorylation of the eisosome core components Pil1 and Lsp1 was not exerted directly by Pkc1, but involved signaling through the Slt2 MAPK module.
  4. Walther T, Brickner J, Aguilar P, Bernales S, Pantoja C, Walter P. Eisosomes mark static sites of endocytosis. Nature. 2006;439:998-1003 pubmed
    ..meaning into or portal, and 'soma', meaning body), are composed primarily of two cytoplasmic proteins, Pil1 and Lsp1. A plasma membrane protein, Sur7, localizes to eisosomes...
  5. Wang H, Kakaradov B, Collins S, Karotki L, Fiedler D, Shales M, et al. A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Mol Cell Proteomics. 2009;8:1361-81 pubmed publisher
  6. Ziółkowska N, Karotki L, Rehman M, Huiskonen J, Walther T. Eisosome-driven plasma membrane organization is mediated by BAR domains. Nat Struct Mol Biol. 2011;18:854-6 pubmed publisher
    ..Eisosomes are key complexes for yeast plasma membrane organization, containing primarily Pil1 and Lsp1. Here we show that both proteins consist mostly of a banana-shaped BAR domain common to membrane sculpting proteins,..
  7. Moreira K, Schuck S, Schrul B, Fr hlich F, Moseley J, Walther T, et al. Seg1 controls eisosome assembly and shape. J Cell Biol. 2012;198:405-20 pubmed publisher
    ..Eisosomes are composed of two main cytoplasmic proteins, Pil1 and Lsp1, that form a scaffold around furrow-like plasma membrane invaginations...
  8. Fröhlich F, Christiano R, Olson D, Alcazar Roman A, DECAMILLI P, Walther T. A role for eisosomes in maintenance of plasma membrane phosphoinositide levels. Mol Biol Cell. 2014;25:2797-806 pubmed publisher
    ..membrane, but the molecular function of their major protein subunits, the BAR domain-containing proteins Pil1 and Lsp1, is poorly understood...
  9. Fu J, Hou J, Chen L, Wang M, Shen Y, Zhang Z, et al. The yeast BDF1 regulates endocytosis via LSP1 under salt stress. Curr Microbiol. 2015;70:671-8 pubmed publisher
    ..We deleted some of the most significant down-regulated genes and did the spot assay. The results revealed that LSP1, an upstream component of endocytosis pathway, and CIN5, a transcription factor that mediates cellular resistance ..

More Information


  1. Olivera Couto A, Salzman V, Mailhos M, Digman M, Gratton E, Aguilar P. Eisosomes are dynamic plasma membrane domains showing pil1-lsp1 heteroligomer binding equilibrium. Biophys J. 2015;108:1633-1644 pubmed publisher
    ..cerevisiae, these domains are structured by scaffolds composed mainly by two cytoplasmic proteins Pil1 and Lsp1. Eisosomes are immobile domains, have relatively uniform size, and encompass thousands of units of the core ..
  2. Laxman S, Tu B. Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae. PLoS ONE. 2011;6:e26081 pubmed publisher
    ..Our studies also suggest the CEN.PK strain background of S. cerevisiae may be particularly useful for investigations of nitrogen starvation-induced diploid pseudohyphal growth. ..