Gene Symbol: LRE1
Description: Lre1p
Alias: Lre1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Versele M, Thevelein J. Lre1 affects chitinase expression, trehalose accumulation and heat resistance through inhibition of the Cbk1 protein kinase in Saccharomyces cerevisiae. Mol Microbiol. 2001;41:1311-26 pubmed
    ..We have isolated the LRE1 gene as a multicopy suppressor of glucose-induced loss of heat resistance...
  2. Lai M, Silverman S, Gaughran J, Kirsch D. Multiple copies of PBS2, MHP1 or LRE1 produce glucanase resistance and other cell wall effects in Saccharomyces cerevisiae. Yeast. 1997;13:199-213 pubmed
    ..third plasmid mapped to the previously uncharacterized YCL051W open reading frame and this gene was therefore named LRE1 (laminarinase resistance). The LRE1 gene encodes a non-essential 604 amino acid hydrophilic protein...
  3. Alonso Monge R, Real E, Wojda I, Bebelman J, Mager W, Siderius M. Hyperosmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects. Mol Microbiol. 2001;41:717-30 pubmed
    ..This phenotype is suppressed by overexpression of LRE1, HLR1 and WSC3, all genes known to influence cell wall composition...
  4. Bialek Wyrzykowska U, Bauer B, Wagner W, Kohlwein S, Schweyen R, Ragnini A. Low levels of Ypt protein prenylation cause vesicle polarization defects and thermosensitive growth that can be suppressed by genes involved in cell wall maintenance. Mol Microbiol. 2000;35:1295-311 pubmed
    ..bind the unconventional type V myosin Myo2, or of genes involved in cell wall maintenance, such as SLG1, GFA1 and LRE1, suppresses mrs6-2 thermosensitivity...
  5. McDaniel S, Hepperla A, Huang J, Dronamraju R, Adams A, Kulkarni V, et al. H3K36 Methylation Regulates Nutrient Stress Response in Saccharomyces cerevisiae by Enforcing Transcriptional Fidelity. Cell Rep. 2017;19:2371-2382 pubmed publisher
    ..These results suggest that Set2-enforced transcriptional fidelity is critical to the proper regulation of inducible and highly regulated transcription programs. ..
  6. Mancini Lombardi I, Palani S, Meitinger F, Darieva Z, Hofmann A, Sharrocks A, et al. Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner. Curr Biol. 2013;23:1736-45 pubmed publisher
    ..We identified the protein Lre1 as a direct inhibitor of Cbk1-Mob2 catalytic activity...
  7. Racki W, Becam A, Nasr F, Herbert C. Cbk1p, a protein similar to the human myotonic dystrophy kinase, is essential for normal morphogenesis in Saccharomyces cerevisiae. EMBO J. 2000;19:4524-32 pubmed
  8. Mayordomo I, Sanz P. The Saccharomyces cerevisiae 14-3-3 protein Bmh2 is required for regulation of the phosphorylation status of Fin1, a novel intermediate filament protein. Biochem J. 2002;365:51-6 pubmed transcriptional regulation such as Mbf1, Gcr2 and Reg2, and a variety of other different proteins (Ppt1, Lre1, Rps0A and Ylr177w)...
  9. Sekiya Kawasaki M, Abe M, Saka A, Watanabe D, Kono K, Minemura Asakawa M, et al. Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae. Genetics. 2002;162:663-76 pubmed
    ..We demonstrate that all of the multicopy suppressors obtained (WSC1, WSC3, MTL1, ROM2, LRE1, ZDS1, and MSB1) and the constitutively active RHO1 mutations tested restore 1,3-beta-glucan synthesis in the GS ..

More Information


  1. Jansen J, Wanless A, Seidel C, Weiss E. Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control. Curr Biol. 2009;19:2114-20 pubmed publisher
    ..This work suggests a novel system by which cells coordinate localized expression of genes involved in processes critical for cell growth and division. ..