Gene Symbol: LOC1
Species: Saccharomyces cerevisiae S288c
Long R, Gu W, Meng X, Gonsalvez G, Singer R, Chartrand P. An exclusively nuclear RNA-binding protein affects asymmetric localization of ASH1 mRNA and Ash1p in yeast. J Cell Biol. 2001;153:307-18 pubmed
..Using this element in the three-hybrid in vivo RNA-binding assay, we identified a protein, Loc1p, that binds in vitro directly to the wild-type ASH1 3'-UTR RNA, but not to a mutant RNA incapable of localizing to ..
Harnpicharnchai P, Jakovljevic J, Horsey E, Miles T, Roman J, Rout M, et al
. Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell. 2001;8:505-15 pubmed
..These results demonstrate that proteomic approaches in concert with genetic tools provide powerful means to purify and characterize ribosome assembly intermediates. ..
Komili S, Farny N, Roth F, Silver P. Functional specificity among ribosomal proteins regulates gene expression. Cell. 2007;131:557-71 pubmed
..Together, our data indicate complex specialization of ribosomal proteins for specific cellular processes and support the existence of a ribosomal code. ..
Shen Z, Paquin N, Forget A, Chartrand P. Nuclear shuttling of She2p couples ASH1 mRNA localization to its translational repression by recruiting Loc1p and Puf6p. Mol Biol Cell. 2009;20:2265-75 pubmed publisher
..We find that She2p interacts with both Loc1p and Puf6p and that excluding She2p from the nucleus decreases this interaction...
Niedner A, Müller M, Moorthy B, Jansen R, Niessing D. Role of Loc1p in assembly and reorganization of nuclear ASH1 messenger ribonucleoprotein particles in yeast. Proc Natl Acad Sci U S A. 2013;110:E5049-58 pubmed publisher
..The nucleolar localization of ASH1 mRNA protein 1 (Loc1p) is required for efficient ASH1 mRNA localization...
Shimoji K, Jakovljevic J, Tsuchihashi K, Umeki Y, Wan K, Kawasaki S, et al
. Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. Nucleic Acids Res. 2012;40:4574-88 pubmed publisher
Urbinati C, Gonsalvez G, Aris J, Long R. Loc1p is required for efficient assembly and nuclear export of the 60S ribosomal subunit. Mol Genet Genomics. 2006;276:369-77 pubmed
b>Loc1p is an exclusively nuclear dsRNA-binding protein that affects the asymmetric sorting of ASH1 mRNA to daughter cells in Saccharomyces cerevisiae...
Fuentes J, Datta K, Sullivan S, Walker A, Maddock J. In vivo functional characterization of the Saccharomyces cerevisiae 60S biogenesis GTPase Nog1. Mol Genet Genomics. 2007;278:105-23 pubmed
..Several conserved charge-to-alanine substitutions outside the GTPase domain display modest growth phenotypes indicating that these residues are not critical for function. ..
Yamada H, Horigome C, Okada T, Shirai C, Mizuta K. Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity. RNA. 2007;13:1977-87 pubmed
..These results suggest that Rrp14p has dual functions in ribosome synthesis and polarized cell growth. ..