Gene Symbol: LOC1
Description: Loc1p
Alias: Loc1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Long R, Gu W, Meng X, Gonsalvez G, Singer R, Chartrand P. An exclusively nuclear RNA-binding protein affects asymmetric localization of ASH1 mRNA and Ash1p in yeast. J Cell Biol. 2001;153:307-18 pubmed
    ..Using this element in the three-hybrid in vivo RNA-binding assay, we identified a protein, Loc1p, that binds in vitro directly to the wild-type ASH1 3'-UTR RNA, but not to a mutant RNA incapable of localizing to ..
  2. Harnpicharnchai P, Jakovljevic J, Horsey E, Miles T, Roman J, Rout M, et al. Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell. 2001;8:505-15 pubmed
    ..These results demonstrate that proteomic approaches in concert with genetic tools provide powerful means to purify and characterize ribosome assembly intermediates. ..
  3. Komili S, Farny N, Roth F, Silver P. Functional specificity among ribosomal proteins regulates gene expression. Cell. 2007;131:557-71 pubmed
    ..Together, our data indicate complex specialization of ribosomal proteins for specific cellular processes and support the existence of a ribosomal code. ..
  4. Shen Z, Paquin N, Forget A, Chartrand P. Nuclear shuttling of She2p couples ASH1 mRNA localization to its translational repression by recruiting Loc1p and Puf6p. Mol Biol Cell. 2009;20:2265-75 pubmed publisher
    ..We find that She2p interacts with both Loc1p and Puf6p and that excluding She2p from the nucleus decreases this interaction...
  5. Niedner A, Müller M, Moorthy B, Jansen R, Niessing D. Role of Loc1p in assembly and reorganization of nuclear ASH1 messenger ribonucleoprotein particles in yeast. Proc Natl Acad Sci U S A. 2013;110:E5049-58 pubmed publisher
    ..The nucleolar localization of ASH1 mRNA protein 1 (Loc1p) is required for efficient ASH1 mRNA localization...
  6. Shimoji K, Jakovljevic J, Tsuchihashi K, Umeki Y, Wan K, Kawasaki S, et al. Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. Nucleic Acids Res. 2012;40:4574-88 pubmed publisher
  7. Urbinati C, Gonsalvez G, Aris J, Long R. Loc1p is required for efficient assembly and nuclear export of the 60S ribosomal subunit. Mol Genet Genomics. 2006;276:369-77 pubmed
    b>Loc1p is an exclusively nuclear dsRNA-binding protein that affects the asymmetric sorting of ASH1 mRNA to daughter cells in Saccharomyces cerevisiae...
  8. Fuentes J, Datta K, Sullivan S, Walker A, Maddock J. In vivo functional characterization of the Saccharomyces cerevisiae 60S biogenesis GTPase Nog1. Mol Genet Genomics. 2007;278:105-23 pubmed
    ..Several conserved charge-to-alanine substitutions outside the GTPase domain display modest growth phenotypes indicating that these residues are not critical for function. ..
  9. Yamada H, Horigome C, Okada T, Shirai C, Mizuta K. Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity. RNA. 2007;13:1977-87 pubmed
    ..These results suggest that Rrp14p has dual functions in ribosome synthesis and polarized cell growth. ..

More Information


  1. Shirai C, Mizuta K. SUMO mediates interaction of Ebp2p, the yeast homolog of Epstein-Barr virus nuclear antigen 1-binding protein 2, with a RING finger protein Ris1p. Biosci Biotechnol Biochem. 2008;72:1881-6 pubmed
    ..A SUMO-binding motif of Ris1p was required for interaction with Ebp2p. These results suggest that SUMO mediates the interaction between Ebp2p and SUMO related proteins and that Ebp2p switches its interaction partners via sumoylation. ..
  2. Shahbabian K, Jeronimo C, Forget A, Robert F, Chartrand P. Co-transcriptional recruitment of Puf6 by She2 couples translational repression to mRNA localization. Nucleic Acids Res. 2014;42:8692-704 pubmed publisher
    ..The recruitment of Puf6 depends on prior co-transcriptional loading of Loc1, an exclusively nuclear protein...
  3. Yang Y, Ting Y, Liang K, Lo K. The Roles of Puf6 and Loc1 in 60S Biogenesis Are Interdependent, and Both Are Required for Efficient Accommodation of Rpl43. J Biol Chem. 2016;291:19312-23 pubmed publisher
    Puf6 and Loc1 have two important functional roles in the cells, asymmetric mRNA distribution and ribosome biogenesis. Puf6 and Loc1 are localized predominantly in the nucleolus...