Gene Symbol: LEU4
Description: 2-isopropylmalate synthase LEU4
Alias: 2-isopropylmalate synthase LEU4
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Casalone E, Barberio C, Cavalieri D, Polsinelli M. Identification by functional analysis of the gene encoding alpha-isopropylmalate synthase II (LEU9) in Saccharomyces cerevisiae. Yeast. 2000;16:539-45 pubmed
    ..A mutant in which both ORF YOR108w and LEU4 gene have been deleted proved to be leucine auxotrophic and alpha-isopropylmalate synthase (alpha-IPMS)-negative...
  2. Beltzer J, Morris S, Kohlhaw G. Yeast LEU4 encodes mitochondrial and nonmitochondrial forms of alpha-isopropylmalate synthase. J Biol Chem. 1988;263:368-74 pubmed
    The LEU4 gene of Saccharomyces cerevisiae is the major structural gene involved in the production of alpha-isopropylmalate synthase...
  3. Stella C, Korch C, Ramos E, Bauer A, Kölling R, Mattoon J. The Saccharomyces cerevisiae LEP1/SAC3 gene is associated with leucine transport. Mol Gen Genet. 1999;262:332-41 pubmed
    ..A new mutant defective in both group-specific transport activities was isolated by employing a gap1 leu4 strain and selecting for trifluoroleucine-resistant mutants which also showed greatly reduced ability to utilize L-..
  4. Oba T, Nomiyama S, Hirakawa H, Tashiro K, Kuhara S. Asp578 in LEU4p is one of the key residues for leucine feedback inhibition release in sake yeast. Biosci Biotechnol Biochem. 2005;69:1270-3 pubmed
    We identified a new mutation, Asp578Tyr, in alpha-isopropylmalate synthase (a LEU4 gene product) that releases leucine feedback inhibition and causes hyperproduction of isoamyl alcohol (i-AmOH) in sake yeast...
  5. Ano A, Suehiro D, Cha aim K, Aritomi K, Phonimdaeng P, Nontaso N, et al. Combinatorial gene overexpression and recessive mutant gene introduction in sake yeast. Biosci Biotechnol Biochem. 2009;73:633-40 pubmed
    ..Moreover, none of these sake strains had extraneous sequences, and they are thus suitable for use in commercial applications. ..
  6. López G, Quezada H, Duhne M, González J, Lezama M, El Hafidi M, et al. Diversification of Paralogous α-Isopropylmalate Synthases by Modulation of Feedback Control and Hetero-Oligomerization in Saccharomyces cerevisiae. Eukaryot Cell. 2015;14:564-77 pubmed publisher
    ..The budding yeast Saccharomyces cerevisiae has two paralogous genes, LEU4 and LEU9, that encode α-IPM synthase (α-IPMS) isozymes...
  7. Kingsbury J, Sen N, Cardenas M. Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae. PLoS Genet. 2015;11:e1005714 pubmed publisher
  8. Ohta E, Nakayama Y, Mukai Y, Bamba T, Fukusaki E. Metabolomic approach for improving ethanol stress tolerance in Saccharomyces cerevisiae. J Biosci Bioeng. 2016;121:399-405 pubmed publisher
    ..Our results show that simultaneous deletion of LEU4 and LEU9 (leading to accumulation of valine) or INM1 and INM2 (leading to reduction of inositol) significantly ..